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  • In Vivo Product
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  • Activator
  • Inhibitor
  • Metals and Ions
  • 3D Structure (PDB)
• Enzyme Kinetic Parameters
• • k_cat Value (Turnover Number)
  • K_M Value
  • K_i Value
  • IC₅₀ Value
• References & Links
• • References
  • Links

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Ligand propane

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (11 results)

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Show Substrate (11 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.11.2.1

propane + H2O2 = isopropanol + H2O

742332

-

1.14.13.227

propane + NADPH + H+ + O2 = propan-2-ol + NADP+ + H2O

738714

-

1.14.13.230

propane + NADH + H+ + O2 = propan-1-ol + NAD+ + H2O

739010, 739007

-

1.14.13.230

propane + NADH + H+ + O2 = propan-2-ol + NAD+ + H2O

739010

-

1.14.13.230

2 entries

1.14.13.25

propane + NAD(P)H + O2 = 1-propanol + 2-propanol + NAD(P)+ + H2O

438920, 438921, 438934, 438947

-

1.14.15.3

n-propane + reduced rubredoxin + O2 = 1-propanol + oxidized rubredoxin + H2O

746483

-

1.14.15.3

propane + NADPH + H+ + O2 = 1-propanol + NADP+ + H2O

673211, 738714

-

1.14.15.3

propane + NADPH + H+ + O2 = propan-1-ol + NADP+ + H2O

738714

-

1.14.15.3

propane + NADPH + H+ + O2 = propanol + NADP+ + H2O

671481

-

1.14.18.3

2 propane + 2 reduced acceptor + 2 H+ + 2 O2 = 1-propanol + 2-propanol + 2 acceptor + 2 H2O

684114

-

1.14.18.3

propane + duroquinol + O2 = 2-propanol + propanal + duroquinone + H2O

716110

-

1.14.15.3

4 entries

1.14.18.3

2 entries

Product in Enzyme-catalyzed Reactions (8 results)

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Show Product (8 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.18.6.1

CO + dithionite + H+ = CH4 + C2H6 + C2H4 + C3H6 + C3H8 + ?

-

-

1.18.6.1

dithionite + H+ + N2 + ATP + CO2 = CO + CH4 + C2H6 + C3H6 + C3H8 + C4H8 + C4H10 + ?

-

-

1.18.6.1

reduced ferredoxin + H+ + CH3NC + ATP = oxidized ferredoxin + CH4 + C2H4 + C3H6 + C3H8 + CH3NH2 + ADP + phosphate

440145, , 440154, 440158

-

1.18.6.2

CO + H+ + ATP = C2H4 + C2H6 + C3H8 + H2O + H2 + phosphate

-

-

1.18.6.2

CO + ATP + dithionite + ? = ethene + ethane + propane + ?

-

-

4.1.99.5

n-butanal + O2 + 2 NADPH + 2 H+ = n-propane + formate + H2O + 2 NADP+

-

-

4.1.99.5

butanal + O2 + 2 NADH + 2 H+ = propane + formate + H2O + 2 NAD+

-

-

4.1.99.5

isobutyraldehyde + O2 + 2 NADPH + 2 H+ = propane + formate + H2O + 2 NADP+

-

-

1.18.6.1

3 entries

1.18.6.2

2 entries

4.1.99.5

3 entries

Inhibitor in Enzyme-catalyzed Reactions (2 results)

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Show Inhibitors (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.14.15.3

inhibits oxidation of methyl tert-butyl ether

657600

-

1.14.99.39

noncompetitive

695723

-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

4.1.1.20

4xg1, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.14.13.230

0.55

-

product propan-1-ol, pH 7.2, 25°C

739010

1.14.13.230

0.98

-

product propan-2-ol, pH 7.2, 25°C

739010

1.14.13.230

2 entries

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.14.13.230

0.00094

-

pH 7.2, 25°C

739010

K_i Value (3 results)

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Show KI Value (3 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.14.15.3

0.192

-

inhibits oxidation of methyl tert-butyl ether

657600

1.14.99.39

0.44

-

value derived from intercept replot

695723

1.14.99.39

1.43

-

value derived from slope replot

695723

1.14.99.39

2 entries

References & Links

Literature References (18)

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Show Reference (18 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

438920

411486

The soluble methane mono-oxygenase of Methylococcus capsulatus (Bath). Its ability to oxygenate n-alkanes, n-alkenes, ethers, and alicyclic, aromatic and heterocyclic compounds

1977

Colby, J.; Stirling, D.I.; Dalton, H.

Biochem. J.

165

395-402

438921

15544

Purification and properties of the methane mono-oxygenase enzyme system from Methylosinus trichosporium OB3b

1977

Tonge, G.M.; Harrison, D.E.F.; Higgins, I.J.

Biochem. J.

161

333-344

438934

1917992

Oxidation of deuterated compounds by high specific activity methane monooxygenase from Methylosinus trichosporium. Mechanistic implications

1991

Rataj, M.J.; Kauth, J.E.; Donnelly, M.I.

J. Biol. Chem.

266

18684-18690

438947

10473397

Purification and characterization of the soluble methane monooxygenase of the type II methanotrophic bacterium Methylocystis sp. strain WI 14

1999

Grosse, S.; Laramee, L.; Wendlandt, K.D.; McDonald, I.R.; Miguez, C.B.; Kleber, H.P.

Appl. Environ. Microbiol.

65

3929-3935

440145

4134899

Nitrogenase

1974

Eady, R.R.; Postgate, J.R.

Nature

249

805-810

440154

4362294

Purification of nitrogenase and crystallization of its Mo-Fe protein

1972

Burns, R.C.; Hardy, R.W.F.

Methods Enzymol.

24

480-496

440158

4670204

Nitrogenase complex and its components

1972

Bulen, W.A.; LeComte, J.R.

Methods Enzymol.

24B

456-470

657600

15294784

Oxidation of methyl tert-butyl ether by alkane hydroxylase in dicyclopropylketone-induced and n-octane-grown Pseudomonas putida GPo1

2004

Smith, C.A.; Hyman, M.R.

Appl. Environ. Microbiol.

70

4544-4550

671481

16391142

Propane and n-butane oxidation by Pseudomonas putida GPo1

2006

Johnson, E.L.; Hyman, M.R.

Appl. Environ. Microbiol.

72

950-952

673211

15961032

Expanding the alkane oxygenase toolbox: new enzymes and applications

2005

van Beilen, J.B.; Funhoff, E.G.

Curr. Opin. Biotechnol.

16

308-314

684114

18605740

Controlled oxidation of hydrocarbons by the membrane-bound methane monooxygenase: the case for a tricopper cluster

2008

Chan, S.I.; Yu, S.S.

Acc. Chem. Res.

41

969-979

695723

16349014

Kinetic studies of ammonia monooxygenase inhibition in Nitrosomonas europaea by hydrocarbons and halogenated hydrocarbons in an optimized whole-cell assay

1993

Keener, W.K.; Arp, D.J.

Appl. Environ. Microbiol.

59

2501-2510

716110

21419924

Particulate methane monooxygenase from Methylosinus trichosporium OB3b

2011

Miyaji, A.

Methods Enzymol.

495

211-225

738714

17046531

Gene structure and regulation of alkane monooxygenases in propane-utilizing Mycobacterium sp. TY-6 and Pseudonocardia sp. TY-7

2006

Kotani, T.; Kawashima, Y.; Yurimoto, H.; Kato, N.; Sakai, Y.

J. Biosci. Bioeng.

102

184-192

739007

17526838

Butane monooxygenase of Pseudomonas butanovora: purification and biochemical characterization of a terminal-alkane hydroxylating diiron monooxygenase

2007

Dubbels, B.L.; Sayavedra-Soto, L.A.; Arp, D.J.

Microbiology

153

1808-1816

739010

19383682

Kinetic characterization of the soluble butane monooxygenase from Thauera butanivorans, formerly Pseudomonas butanovora

2009

Cooley, R.B.; Dubbels, B.L.; Sayavedra-Soto, L.A.; Bottomley, P.J.; Arp, D.J.

Microbiology

155

2086-2096

742332

24607599

Oxidations catalyzed by fungal peroxygenases

2014

Hofrichter, M.; Ullrich, R.

Curr. Opin. Chem. Biol.

19

116-125

746483

28827709

Electrochemical hydroxylation of C3-C12 n-alkanes by recombinant alkane hydroxylase (AlkB) and rubredoxin-2 (AlkG) from Pseudomonas putida GPo1

2017

Tsai, Y.F.; Luo, W.I.; Chang, J.L.; Chang, C.W.; Chuang, H.C.; Ramu, R.; Wei, G.T.; Zen, J.M.; Yu, S.S.

Sci. Rep.

7

8369

Links to other databases for propane

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Show Links (1 entry)

ChEBI

PubChem

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