Ligand ceramide

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Basic Ligand Information

Molecular Structure
Picture of ceramide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C22H42NO3R
ceramide
VHZNWGVARKVWFF-ODOOKIQISA-N
Synonyms:
(4E)-sphing-4-enine ceramide, a (4E)-sphing-4-enine ceramide, a ceramide, an N-acylsphingosine, N-acyl-sphingosine, N-acyl-threo-trans-sphingosine, N-acylsphingosine


Show all pahtways known for Show all BRENDA pathways known for ceramide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(4E)-sphing-4-enine ceramide + ferrocytochrome b5 + O2 + H+ = (4E,8E)-sphing-4,8-dienine ceramide + ferricytochrome b5 + H2O
show the reaction diagram
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UDP-galactose + ceramide = UDP + D-galactosylceramide
show the reaction diagram
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cytidine diphosphate choline + N-acyl-threo-trans-sphingosine = CMP + sphingomyelin
show the reaction diagram
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a ceramide + a phosphatidylethanolamine = a ceramide phosphoethanolamine + a 1,2-diacyl-sn-glycerol
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (28 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
sphingomyelin + H2O = ceramide + phosphorylcholine
show the reaction diagram
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oligoglycosylglucosyl-(1<->1)-ceramide + H2O = ceramide + oligoglycosylglucose
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(4E)-sphing-4-enine ceramide + ferrocytochrome b5 + O2 + H+ = (4E,8E)-sphing-4,8-dienine ceramide + ferricytochrome b5 + H2O
show the reaction diagram
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UDP-galactose + ceramide = ?
show the reaction diagram
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UDP-galactose + ceramide = UDP + D-galactosylceramide
show the reaction diagram
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ATP + ceramide = ADP + ceramide 3-phosphate
show the reaction diagram
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a ceramide + a phosphatidylethanolamine = a ceramide phosphoethanolamine + a 1,2-diacyl-sn-glycerol
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (88 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
sphingomyelin + diacylglycerol = ceramide + phosphatidylcholine
show the reaction diagram
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glucosylceramide + H2O = D-glucose + ceramide
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
30% activation, stimulation of synthesis of 20:4 cholesteryl ester and 18:2 cholesteryl ester, but not of 16:0 cholesteryl ester, a phosphocholine ether matrix abolishes the activation effect
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ceramide induces increase of PP2A activity
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inhibition or activation depends on substrate
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Inhibitor in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
treatment with exogenous ceramides, or increasing the endogenous ceramide levels inhibits HMGCR by 6080%
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inhibits PLD at the catalytic subunit by competing with phosphatidylinositol-4,5-bisphosphate. Ceramide levels are increased coincidentally with reduced PLD activity in senescent cells. Treatment of cells with ceramide results in a dose-dependent decrease in PLD activity and diacylglycerol accumulation
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inhibition or activation depends on substrate
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hydrolysis of lactosyl ceramide
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mediates enzyme inhibition to about 60% by activating protein kinase A and protein kinase Czeta, that regulate ion transporter activities. Inhibition of the kinase reverses the inhibitory effect of ceramide on Na+-ATPase
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Enzyme Kinetic Parameters

KM Value (12 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.23
-
pH 6.6, 25C
0.3
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IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0001
-
pH 7.4, 37C

References & Links

Links to other databases for ceramide

ChEBI
PubChem
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PubChem