Ligand 5-fluorouracil-mismatched double-stranded DNA
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Basic Ligand Information
5-fluorouracil-mismatched double-stranded DNA
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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5-fluorouracil-mismatched double-stranded DNA + H2O = 5-fluorouracil + double-stranded DNA with abasic site
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Substrate in Enzyme-catalyzed Reactions (2 results)
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5-fluorouracil-mismatched double-stranded DNA + H2O = 5-fluorouracil + double-stranded DNA with abasic site
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5-fluorouracil-mismatched double-stranded DNA + H2O = 5-fluorouracil + double-stranded DNA with abasic site
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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3.7
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cleavage of 5-fluorouracil from G/5-fluorouracil mismatch
References & Links
Literature References (5)
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The enigmatic thymine DNA glycosylase
2007
Cortazar, D.; Kunz, C.; Saito, Y.; Steinacher, R.; Schรยคr, P.
DNA Repair
6
489-504
A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site
2002
Sartori, A.A.; Fitz-Gibbon, S.; Yang, H.; Miller, J.H.; Jiricny, J.
EMBO J.
21
3182-3191
Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability
2006
Bennett, M.T.; Rodgers, M.T.; Hebert, A.S.; Ruslander, L.E.; Eisele, L.; Drohat, A.C.
J. Am. Chem. Soc.
128
12510-12519
Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG
2007
Morgan, M.T.; Bennett, M.T.; Drohat, A.C.
J. Biol. Chem.
282
27578-27586
The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs
2003
Hardeland, U.; Bentele, M.; Jiricny, J.; Schaer, P.
Nucleic Acids Res.
31
2261-2271
Links to other databases for 5-fluorouracil-mismatched double-stranded DNA