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Ligand 2-methylpropanamine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.30

2-methylpropanamine + FADH2 + O2 = N-hydroxy-2-methylpropan-1-amine + FAD + H2O

737549

-

1.14.14.30

2-methylpropanamine + FMNH2 + O2 = N-hydroxy-2-methylpropan-1-amine + FMN + H2O

737549

-

1.14.14.30

2 entries

Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Substrate (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.30

2-methylpropanamine + FADH2 + O2 = N-hydroxy-2-methylpropan-1-amine + FAD + H2O

737549

-

1.14.14.30

2-methylpropanamine + FMNH2 + O2 = N-hydroxy-2-methylpropan-1-amine + FMN + H2O

737549, 738507

-

1.14.14.30

2 entries

1.4.3.12

2-methylpropan-1-amine + O2 + H2O = ?

724688

-

1.4.3.21

isobutylamine + H2O + O2 = isobutyraldehyde + NH3 + H2O2

726290

-

2.6.1.115

2-methylpropan-1-amine + 2-oxoglutarate = 2-methylpropanal + L-glutamate

750312

-

Product in Enzyme-catalyzed Reactions (6 results)

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Show Product (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.4.1.28

isobutanal + NH3 + NADH + H+ = 2-methylpropan-1-amine + NAD+ + H2O

0

-

3.5.1.65

N5-isobutyl-L-glutamine + H2O = L-glutamate + isobutylamine

0

-

3.8.1.8

2,4-di(N-isobutylamino)-6-hydroxy-1,3,5-triazine + H2O = 6-[(2-methylpropyl)amino]-1,3,5-triazine-2,4-diol + isobutylamine

0

-

4.1.1.14

L-valine = i-butylamine + CO2

0, 3968

-

4.1.1.57

L-Val = 2-Methylpropylamine + CO2

0

-

4.1.1.B12

L-valine = 2-methylpropanamine + CO2

0

-

Activator in Enzyme-catalyzed Reactions (2 results)

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Show Activating Compound (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.2.8

slight activation

742110

-

1.1.5.5

-

740180

-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

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Show Inhibitors (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.37

-

486820

-

3.4.21.50

-

36618

-

4.1.1.14

-

3970

-

6.3.1.6

-

958

-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

4.2.1.84

2qdy, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.4.3.21

7.4

-

at pH 7.4, 37°C

726290

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.4.3.21

3.42

-

at pH 7.4, 37°C

726290

References & Links

Literature References (12)

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Show Reference (12 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

958

-

Some properties of the theanine synthesizing enzyme in tea seedlings

1965

Sasaoka, K.; Kito, M.; Onishi, Y.

Agric. Biol. Chem.

29

984-988

3968

-

Leucin-carboxylase aus marinen Rhodophyceae: Vorkommen, Verbreitung und einige Eigenschaften

1972

Hartmann, T.

Phytochemistry

11

1327-1336

3970

13918558

Inhibition of leucine decarboxylase by thiol-binding reagents

1962

Sutton, C.R.; King, H.K.

Arch. Biochem. Biophys.

96

360-370

36618

7845202

Lysyl endopeptidase of Achromobacter lyticus

1994

Sakiyama, F.; Masaki, T.

Methods Enzymol.

244

126-137

486820

-

delta-Aminolevulinic acid synthetase

1972

Jordan, P.M.; Shemin, D.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

7

339-356

724688

-

Cyclohexylamine oxidase as a useful biocatalyst for the kinetic resolution and dereacemization of amines

2012

Leisch, H.; Grosse, S.; Iwaki, H.; Hasegawa, Y.; Lau, P.

Can. J. Chem.

90

39-45

726290

22238597

Implication for functions of the ectopic adipocyte copper amine oxidase (AOC3) from purified enzyme and cell-based kinetic studies

2012

Shen, S.H.; Wertz, D.L.; Klinman, J.P.

PLoS ONE

7

e29270

737549

9056232

Purification and characterization of isobutylamine N-hydroxylase from the valanimycin producer Streptomyces viridifaciens MG456-hF10

1997

Parry, R.; Li, W.

Arch. Biochem. Biophys.

339

47-54

738507

8990292

Cloning, analysis, and overexpression of the gene encoding isobutylamine N-hydroxylase from the valanimycin producer, Streptomyces viridifaciens

1997

Parry, R.J.; Li, W.; Cooper, H.N.

J. Bacteriol.

179

409-416

740180

25229857

Effect of amines as activators on the alcohol-oxidizing activity of pyrroloquinoline quinone-dependent quinoprotein alcohol dehydrogenase

2014

Takeda, K.; Ishida, T.; Igarashi, K.; Samejima, M.; Nakamura, N.; Ohno, H.

Biosci. Biotechnol. Biochem.

78

1195-1198

742110

25229857

Effect of amines as activators on the alcohol-oxidizing activity of pyrroloquinoline quinone-dependent quinoprotein alcohol dehydrogenase

2014

Takeda, K.; Ishida, T.; Igarashi, K.; Samejima, M.; Nakamura, N.; Ohno, H.

Biosci. Biotechnol. Biochem.

78

1195-1198

750312

28451186

Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis

2016

Awodi, U.; Ronan, J.; Masschelein, J.; De Los Santos, E.; Challis, G.

Chem. Sci.

8

411-415

Links to other databases for 2-methylpropanamine

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Show Links (1 entry)

ChEBI

PubChem