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Ligand glycerophosphoinositol

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

KEGG

Autophagy - animal, Autophagy - other, Autophagy - yeast, Glycerophospholipid metabolism, Glycosylphosphatidylinositol (GPI)-anchor biosynthesis, Inositol phosphate metabolism, Lipoarabinomannan (LAM) biosynthesis, Phosphatidylinositol signaling system, Salmonella infection, Tuberculosis more

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Natural Substrate (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.345

GDP-mannose + 1-phosphatidyl-myo-inositol = ?

736430

-

3.1.4.43

sn-glycero-3-phospho-1-inositol + H2O = ?

288793

-

3.1.4.44

glycerophosphoinositol + H2O = glycerol 3-phosphate + inositol

679873

-

3.1.4.44

sn-glycero-3-phospho-1-D-myo-inositol + H2O = ?

81116

-

3.1.4.44

2 entries

3.1.4.46

glycerophosphoinositol + H2O = sn-glycerol 3-phosphate + inositol

680514

-

Substrate in Enzyme-catalyzed Reactions (13 results)

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Show Substrate (13 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.345

GDP-alpha-D-mannose + 1-phosphatidyl-myo-inositol = GDP + 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol

660449

-

2.4.1.345

GDP-mannose + 1-phosphatidyl-myo-inositol = ?

736430

-

2.4.1.345

2 entries

3.1.4.2

glycerophosphoinositol + H2O = inositol + glycerol 3-phosphate

95138, 646468, 95139

-

3.1.4.43

sn-glycero-3-phospho-1-inositol + H2O = ?

288793

-

3.1.4.43

sn-glycero-3-phospho-1-inositol + H2O = glycerol + inositol 1-phosphate

288793

-

3.1.4.43

sn-glycero-3-phospho-1-inositol + H2O = glycerol + inositol cyclic phosphate

288793

-

3.1.4.44

1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate

653592

-

3.1.4.44

glycerophosphoinositol + H2O = glycerol 3-phosphate + inositol

679873

-

3.1.4.44

sn-glycero-3-phospho-1-D-myo-inositol + H2O = ?

81116

-

3.1.4.44

sn-glycero-3-phospho-1-D-myo-inositol + H2O = sn-glycero 3-phosphate + inositol

81116, 81117

-

3.1.4.46

glycerophosphoinositol + H2O = ?

646467, 680514

-

3.1.4.46

glycerophosphoinositol + H2O = inositol + glycerol-3-phosphate

751846

-

3.1.4.46

glycerophosphoinositol + H2O = sn-glycerol 3-phosphate + inositol

680514

-

3.1.4.43

3 entries

3.1.4.44

4 entries

3.1.4.46

3 entries

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.5

phosphatidylinositol + H2O = lysophosphatidylinositol + glycerophosphorylinositol + a carboxylate

-

-

3.1.4.11

phosphatidylinositol + H2O = 1D-myo-inositol 1-phosphate + glycerophosphoinositol + phosphate

-

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.44

above 3 mM

81116

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.1.4.46

1.8

-

-

680514

3.1.4.46

1.8

-

5 mM Mg2+, pH 7.4, 35°C

680514

3.1.4.46

2 entries

K_M Value (5 results)

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Show KM Value (5 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.4.2

1

-

-

95138

3.1.4.43

2.2

-

-

288793

3.1.4.44

12

-

pH 7.5, 37°C

653592

3.1.4.46

0.39

-

-

680514

3.1.4.46

0.39

-

5 mM Mg2+, pH 7.4, 35°C

680514

3.1.4.46

2 entries

References & Links

Literature References (13)

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Show Reference (13 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

81116

40550

sn-Glycero(3)phosphoinositol glycerophosphohydrolase. A new phosphodiesterase in rat tissues

1979

Dawson, R.M.C.; Hemington, N.; Richards, D.E.; Irvine, R.F.

Biochem. J.

182

39-45

81117

6319195

A novel glycerophosphodiesterase from Bacillus pumilus

1984

Kusser, W.; Fiedler, F.

FEBS Lett.

166

301-306

95138

2829735

Purification and characterization of glpQ-encoded glycerophosphodiester phosphodiesterase from Escherichia coli K-12

1988

Larson, T.J.; van Loo-Bhattacharya, A.T.

Arch. Biochem. Biophys.

260

577-584

95139

2988639

Utilization of exogenous glycerophosphodiesters and glycerol 3-phosphate by inositol-starved yeast, Saccharomyces uvarum

1985

Paltauf, F.; Zinser, E.; Daum, G.

Biochim. Biophys. Acta

835

322-330

288793

192216

A phosphodiesterase in rat kidney cortex that hydrolyses glycerylphosphorylinositol

1977

Dawson, R.M.C.; Hemington, N.

Biochem. J.

162

241-245

646467

14750903

Identification and characterisation of plant glycerophosphodiester phosphodiesterase

2004

Van Der Rest, B.; Rolland, N.; Boisson, A.M.; Ferro, M.; Bligny, R.; Douce, R.

Biochem. J.

379

601-607

646468

12226504

Glycerophosphocholine metabolism in higher plant cells. Evidence of a new glyceryl-phosphodiester phosphodiesterase

2002

Van der Rest, B.; Boisson, A.M.; Gout, E.; Bligny, R.; Douce, R.

Plant Physiol.

130

244-255

653592

12576545

GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors

2003

Zheng, B.; Berrie, C.P.; Corda, D.; Farquhar, M.G.

Proc. Natl. Acad. Sci. USA

100

1745-1750

660449

15939292

Expression and purification of a functionally active recombinant GDP-mannosyltransferase (PimA) from Mycobacterium tuberculosis H37Rv

2005

Gu, X.; Chen, M.; Wang, Q.; Zhang, M.; Wang, B.; Wang, H.

Protein Expr. Purif.

42

47-53

679873

17275818

Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells

2007

Yanaka, N.; Nogusa, Y.; Fujioka, Y.; Yamashita, Y.; Kato, N.

FEBS Lett.

581

712-718

680514

18083802

Escherichia coli cytosolic glycerophosphodiester phosphodiesterase (UgpQ) requires Mg2+, Co2+, or Mn2+ for its enzyme activity

2008

Ohshima, N.; Yamashita, S.; Takahashi, N.; Kuroishi, C.; Shiro, Y.; Takio, K.

J. Bacteriol.

190

1219-1223

736430

23963451

Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria

2013

Giganti, D.; Alegre-Cebollada, J.; Urresti, S.; Albesa-Jove, D.; Rodrigo-Unzueta, A.; Comino, N.; Kachala, M.; Lopez-Fernandez, S.; Svergun, D.I.; Fernandez, J.M.; Guerin, M.E.

J. Biol. Chem.

288

29797-29808

751846

30307043

A novel glycerophosphodiester phosphodiesterase improves phosphate deficiency tolerance in rice

2018

Mehra, P.; Pandey, B.K.; Verma, L.; Giri, J.

Plant Cell Environ.

42

1167-1179

Links to other databases for glycerophosphoinositol

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Show Links (1 entry)

ChEBI

PubChem

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