Ligand Dihydroxyfumarate

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Basic Ligand Information

Molecular Structure
Picture of Dihydroxyfumarate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H4O6
Dihydroxyfumarate
BZCOSCNPHJNQBP-OWOJBTEDSA-N
Synonyms:
dihydroxyfumaric acid
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
meso-tartrate + NAD+ = dihydroxyfumaric acid + NADH
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihydroxyfumarate + NAD+ = ?
show the reaction diagram
-
dihydroxyfumaric acid + NADH = meso-tartrate + NAD+
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
meso-tartrate + NAD+ = dihydroxyfumaric acid + NADH
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
noncompetitive
-
competitive inhibition versus propionyl-CoA, mixed type inhibition versus oxaloacetate
-

Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
11
-
in presence of 0.19 mM NADH

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.69
-
pH 8.0, 37C

References & Links

Links to other databases for Dihydroxyfumarate

ChEBI
PubChem
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PubChem