Ligand 6-methyl-uridine
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Basic Ligand Information
Molecular Structure
C10H14N2O6
6-methyl-uridine
SGKGZYGMLGVQHP-ZOQUXTDFSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (2 results)
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6-methyluridine + phosphate = 6-methyluracil + alpha-D-ribose 1-phosphate
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6-methyluridine + phosphate = 6-methyluracil + alpha-D-ribose 1-phosphate
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Product in Enzyme-catalyzed Reactions (1 result)
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6-methyluracil + alpha-D-ribose 1-phosphate = 6-methyluridine + phosphate
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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Enzyme Kinetic Parameters
IC50 Value (2 results)
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0.015
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at 37°C for 20 min in 30 mM potassium phosphate, pH 8.0, 1.2 mM MgCl2
References & Links
Literature References (4)
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Inhibition of orotidine-5-monophosphate decarboxylase--discoveries and lessons
2008
Kotra, L.P.; Pai, E.F.
Nucleic Acids Symp. Ser.
52
85-86
Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors
2009
Lossani, A.; Torti, A.; Gatti, S.; Bruno, A.; Maserati, R.; Wright, G.E.; Focher, F.
Parasitology
136
595-602
Crystallization and preliminary X-ray study of Vibrio cholerae uridine phosphorylase in complex with 6-methyluracil
2014
Prokofev, I.I.; Lashkov, A.A.; Gabdulkhakov, A.G.; Dontsova, M.V.; Seregina, T.A.; Mironov, A.S.; Betzel, C.; Mikhailov, A.M.
Acta Crystallogr. Sect. F
70
60-63
Substrate specificity of E. coli uridine phosphorylase. Further evidences of high-syn conformation of the substrate in uridine phosphorolysis
2017
Alexeev, C.S.; Sivets, G.G.; Safonova, T.N.; Mikhailov, S.N.
Nucleosides Nucleotides Nucleic Acids
36
107-121
Links to other databases for 6-methyl-uridine
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