Ligand L-fucose

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Basic Ligand Information

Molecular Structure
Picture of L-fucose (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H12O5
L-fucose
SHZGCJCMOBCMKK-DHVFOXMCSA-N
Synonyms:
6-deoxy-L-galactose, a D-threo-aldose, A D-threo aldose, L-fucopyranose


Show all pahtways known for Show all BRENDA pathways known for L-fucose

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-fucose + NAD+ = L-6-deoxyascorbate + NADH
show the reaction diagram
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L-Fucose = ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-nitrophenyl-alpha-L-fucopyranoside + H2O = 4-nitrophenol + L-fucose
show the reaction diagram
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-
4-nitrophenyl-alpha-L-fucopyranoside + H2O = 4-nitrophenol + L-fucose
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (41 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-fucose + NADP+ = 6-deoxy-L-galactono-1,4-lactone + NADPH + H+
show the reaction diagram
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L-fucose + NAD+ = ? + NADH + H+
show the reaction diagram
-
L-fucose + NADPH = fucitol + NADP+
show the reaction diagram
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L-fucose + acceptor = ?
show the reaction diagram
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sucrose + L-fucose = D-glucose + beta-D-fructofuranosyl-(2->1)-L-fucoside
show the reaction diagram
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alpha-D-glucose 1-phosphate + L-fucose = ?
show the reaction diagram
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L-fucose + GlcNAc = GlcNAc-beta-1,3-fucitol
show the reaction diagram
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L-fucose + alpha-D-glucose 1-phosphate = ? + phosphate
show the reaction diagram
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N,N'-diacetylchitobiose + L-fucose = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (50 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
fuconolactone + NADPH + H+ = L-fucose + NADP+
show the reaction diagram
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fucoidan + H2O = L-fucose + L-fucose monosulfate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
20% activation at 250 mM
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Inhibitor in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at high concentrations
-
about 20% inhibition at 0.4 mM
-
5 mM, 50% inhibition
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10 mM, 30% inhibition
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competitive
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (27 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
125
-
pH 8.0, 30°C
26.8
-
pH 7.5, 80°C
56.4
-
at pH 8.5 and 30°C
1.21
-
pH 8.0, 37°C

KM Value (63 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.41
-
pH 8.0, 30°C
28.9
-
-
80.7
-
-
56.3
-
pH 7.5, temperature not specified in the publication
24.8
-
at pH 8.5 and 30°C
12.31
-
0.1 M ethanolamine buffer at pH 9.4
160
-
-
20.7
-
pH 8.0, 37°C
173.6
-
F279Q mutant

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
200
-
above, pH 7.8, 40°C
2.5
-
pH 5.0, 37°C
0.0477
-
at 37°C, pH not specified in the publication

References & Links

Links to other databases for L-fucose

ChEBI
PubChem
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PubChem