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Ligand acetoacetyl-[acyl-carrier protein]

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

lipid metabolism, palmitate biosynthesis

KEGG

Fatty acid biosynthesis, Fatty acid metabolism

MetaCyc

alpha-cyclopiazonate biosynthesis, fatty acid biosynthesis initiation (mitochondria), fatty acid biosynthesis initiation (plant mitochondria), fatty acid biosynthesis initiation (type II), fatty acid elongation -- saturated, octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast), palmitate biosynthesis II (type II fatty acid synthase), palmitate biosynthesis III, streptorubin B biosynthesis, superpathway of fatty acid biosynthesis initiation (E. coli), tetradecanoate biosynthesis (mitochondria) more

Show all BRENDA pathways known for acetoacetyl-[acyl-carrier protein]

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.212

acetoacetyl-[acyl-carrier protein] + NADH = 3-hydroxybutanoyl-[acyl-carrier protein] + NAD+

285678

-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.180

acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacetyl-[acyl-carrier protein] + CoA + CO2

-

-

2.3.1.180

acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2

-

-

2.3.1.180

2 entries

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.100

acetoacetyl-[acyl-carrier protein] + NADPH = D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+

285683, 285668, 285672, 285677, 285673, 285674, 285669, 285670, 703630

-

1.1.1.212

acetoacetyl-[acyl-carrier protein] + NADH = 3-hydroxybutanoyl-[acyl-carrier protein] + NAD+

285678

-

2.3.1.180

acetoacetyl-ACP + acetyl-CoA = acetyl-ACP + acetoacetyl-CoA

720076

-

2.3.3.10

acetyl-CoA + acetoacetyl-ACP + H2O = 3-hydroxy-3-methylglutaryl-ACP

488097

-

Product in Enzyme-catalyzed Reactions (11 results)

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Show Product (11 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.179

acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = acetoacetyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

-

-

2.3.1.180

acetyl-CoA + malonyl-ACP = acetoacetyl-ACP + CoA + CO2

-

-

2.3.1.180

malonyl-ACP + acetyl-CoA = CO2 + CoA + acetoacetyl-ACP

-

-

2.3.1.180

acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacetyl-[acyl-carrier protein] + CoA + CO2

-

-

2.3.1.180

acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2

-

-

2.3.1.39

acetoacetyl-CoA + an [acyl-carrier protein] = CoA + acetoacetyl-[acyl carrier protein]

-

-

2.3.1.39

acetoacetyl-CoA + acyl-carrier protein = CoA + acetoacetyl-[acyl-carrier protein]

-

-

2.3.1.39

acetoacetyl-CoA + an [acyl-carrier protein] = CoA + an acetoacetyl-[acyl-carrier protein]

-

-

2.3.1.180

4 entries

2.3.1.39

3 entries

2.3.1.41

acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxobutanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

-

-

2.3.1.85

acetoacetyl-CoA + an [acyl-carrier protein] = CoA + acetoacetyl-[acyl-carrier protein]

-

-

2.7.8.7

acetoacetyl-CoA + apo-[acyl-carrier protein] = CoA + acetoacetyl-[acyl-carrier protein]

-

-

Enzyme Kinetic Parameters

K_M Value (6 results)

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Show KM Value (6 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.100

0.003

-

-

285673

1.1.1.100

0.0037

-

-

285668

1.1.1.100

0.0079

-

-

285674

1.1.1.100

0.009

-

-

285669

1.1.1.100

0.017

-

-

285677

1.1.1.100

5 entries

1.1.1.212

0.00965

-

-

285678

References & Links

Literature References (12)

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Show Reference (12 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

285668

6756317

Purification and characterizations of beta-ketoacyl-[acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase from Spinacia oleracea leaves

1982

Shimakata, T.; Stumpf, P.K.

Arch. Biochem. Biophys.

218

77-91

285669

7125663

The procaryotic nature of the fatty acid synthetase of developing Carthamus tinctorius L. (Safflower) seeds

1982

Shimakata, T.; Stumpf, P.K.

Arch. Biochem. Biophys.

217

144-154

285670

-

3-Oxoacyl-[acyl carrier protein] reductase: a component of plant fatty acid synthase

1988

Sheldon, P.S.; Safford, R.; Slabas, A.R.; Kekwick, R.G.O.

Biochem. Soc. Trans.

16

392-393

285672

4381013

Studies on the mechanism of fatty acid synthesis. XV. Preparation and general properties of beta-ketoacyl acyl carrier protein reductase from Escherichia coli

1966

Toomey, R.E.; Wakil, S.J.

Biochim. Biophys. Acta

116

189-197

285673

1562581

3-Oxoacyl-[ACP] reductase from oil seed rape (Brassica napus)

1992

Sheldon, P.S.; Kekwick, R.G.O.; Smith, C.G.; Sidebottom, C.; Slabas, A.R.

Biochim. Biophys. Acta

1130

151-159

285674

2244875

3-Oxoacyl-(acyl-carrier protein) reductase from avocado (Persea americana) fruit mesocarp

1990

Sheldon, P.S.; Kekwick, R.G.O.; Sidebottom, C.; Smith, C.G.; Slabas, A.R.

Biochem. J.

271

713-720

285677

16662382

Fatty acid synthetase of Spinacia oleracea leaves

1982

Shimakata, T.; Stumpf, P.K.

Plant Physiol.

69

1257-1262

285678

7075600

The characteristics of some components of the fatty acid synthetase system in the plastids from the mesocarp of avocado (Persea americana) fruit

1982

Caughey, I.; Kekwick, R.G.O.

Eur. J. Biochem.

123

553-561

285683

10801480

The x-ray structure of Brassica napus beta-keto acyl carrier protein reductase and its implications for substrate binding and catalysis

2000

Fisher, M.; Kroon, J.T.M.; Martindale, W.; Stuitje, A.R.; Slabas, A.R.; Rafferty, J.B.

Structure

8

339-347

488097

-

3-Hydroxy-3-methylglutaryl-CoA synthase from baker's yeast

1975

Middleton, B.; Tubbs, P.K.

Methods Enzymol.

35 B

173-177

703630

18721141

Deciphering the key residues in Plasmodium falciparum beta-ketoacyl acyl carrier protein reductase responsible for interactions with Plasmodium falciparum acyl carrier protein

2008

Karmodiya, K.; Modak, R.; Sahoo, N.; Sajad, S.; Surolia, N.

FEBS J.

275

4756-4766

720076

22143070

Mutations to the active site of 3-ketoacyl-ACP synthase III (FabH) increase polyhydroxyalkanoate biosynthesis in transgenic Escherichia coli

2012

Mueller, A.P.; Nomura, C.T.

J. Biosci. Bioeng.

113

300-306

Links to other databases for acetoacetyl-[acyl-carrier protein]

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