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BRENDA support

Ligand 6-oxohexanoic acid

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Basic Ligand Information

Molecular Structure
Picture of 6-oxohexanoic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H10O3
6-oxohexanoic acid
PNPPVRALIYXJBW-UHFFFAOYSA-N
Synonyms:
6-oxo-n-hexanoate, 6-oxohexanoate, Adipate semialdehyde, Adipic semialdehyde, Glutaric semialdehyde


Show all pahtways known for Show all BRENDA pathways known for 6-oxohexanoic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-oxohexanoate + NADP+ + H2O = adipate + NADPH
show the reaction diagram
-
glutaric semialdehyde + NAD+ + H2O = glutarate + NADH + H+
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + NADH
show the reaction diagram
-
6-aminohexanoate + 2-oxoglutarate = 6-oxohexanoate + L-glutamate
show the reaction diagram
-
6-aminohexanoate + 2-oxoglutarate = L-glutamate + 6-oxohexanoate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glutaric semialdehyde + NAD+ + H2O = glutarate + NADH
show the reaction diagram
-
glutaric semialdehyde + NADP+ + H2O = glutarate + NADPH
show the reaction diagram
-
6-oxohexanoate + NADP+ + H2O = adipate + NADPH
show the reaction diagram
-
glutaric semialdehyde + NADP+ + H2O = glutarate + NADPH + 2 H+
show the reaction diagram
-
glutaric semialdehyde + NAD+ + H2O = glutarate + NADH + H+
show the reaction diagram
-
6-oxohexanoic acid + NADH + H+ + NH3 = L-lysine + NAD+ + H2O
show the reaction diagram
-
6-oxohexanoate + L-alanine = 6-aminohexanoate + pyruvate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + NADH
show the reaction diagram
-
hexane-1,6-diol + O2 = 6-oxohexanoic acid + cyclopent-1-ene-1-carbaldehyde + H2O2
show the reaction diagram
-
adipate + NADPH + H+ + ATP = adipate semialdehyde + NADP+ + AMP + diphosphate
show the reaction diagram
-
6-aminohexanoate + 2-oxoglutarate = L-glutamate + 6-oxohexanoate
show the reaction diagram
-
6-aminohexanoate + 2-oxoglutarate = L-glutamate + 6-oxohexanoate
show the reaction diagram
-
2-oxoglutarate + 6-aminohexanoate = glutamate + 6-oxohexanoate
show the reaction diagram
-
epsilon-amino-n-caproate + 4,5-dioxopentanoate = 5-aminolevulinate + 6-oxo-n-hexanoate
show the reaction diagram
-
6-aminohexanoate + 2-oxoglutarate = adipic semialdehyde + L-glutamate
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
product inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (11 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.27
-
recombinant wild-type enzyme, pH 8.2, 25°C, with NADP+

KM Value (13 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0034
-
-
0.016
-
-
0.551
-
recombinant wild-type enzyme, pH 8.2, 25°C, with NADP+

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for 6-oxohexanoic acid

ChEBI
PubChem
ChEBI
PubChem