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Ligand 5'-Deoxythymidine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.2

5'-deoxythymidine + phosphate = thymine + 5-deoxy-alpha-D-ribose 1-phosphate

759867

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2.4.2.4

5'-deoxythymidine + phosphate = ?

672287

-

2.4.2.4

5'-deoxythymidine + phosphate = thymine + 2,5-dideoxy-D-ribose 1-phosphate

672287, 685542

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2.4.2.4

5-deoxythymidine + phosphate = thymine + 2,5-dideoxyribose 1-phosphate

638454

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2.4.2.4

3 entries

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.77

5'-dTMP + thymidine = 5'-deoxythymidine + TMP

0

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.4.9

-

662987

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.4.2.4

260

-

-

672287

2.4.2.4

260

-

in 50 mM potassium phosphate buffer (pH 6.5), at 25°C

672287

2.4.2.4

2 entries

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.2.4

0.4

-

25°C, pH 6.5

672287

2.4.2.4

0.4

-

in 50 mM potassium phosphate buffer (pH 6.5), at 25°C

672287

2.4.2.4

32

-

in 50 mM phosphate buffer, pH 6.8

685542

2.4.2.4

3 entries

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.4.9

0.004

-

-

662987

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

638454

2119230

Purification and characterization of uridine and thymidine phosphorylase from Lactobacillus casei

1990

Avraham, Y.; Grossowicz, N.; Yashphe, J.

Biochim. Biophys. Acta

1040

287-293

662987

14565282

Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors

2003

Munier-Lehmann, H.; Pochet, S.; Dugue, L.; Dutruel, O.; Labesse, G.; Douget, D.

Nucleosides Nucleotides Nucleic Acids

22

801-804

672287

17309433

Substrate specificity of Escherichia coli thymidine phosphorylase

2007

Panova, N.G.; Alexeev, C.S.; Kuzmichov, A.S.; Shcheveleva, E.V.; Gavryushov, S.A.; Polyakov, K.M.; Kritzyn, A.M.; Mikhailov, S.N.; Esipov, R.S.; Miroshnikov, A.I.

Biochemistry

72

21-28

685542

18272369

Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase

2008

Hatano, A.; Harano, A.; Takigawa, Y.; Naramoto, Y.; Toda, K.; Nakagomi, Y.; Yamada, H.

Bioorg. Med. Chem.

16

3866-3870

759867

27846376

Substrate specificity of E. coli uridine phosphorylase. Further evidences of high-syn conformation of the substrate in uridine phosphorolysis

2017

Alexeev, C.S.; Sivets, G.G.; Safonova, T.N.; Mikhailov, S.N.

Nucleosides Nucleotides Nucleic Acids

36

107-121

Links to other databases for 5'-Deoxythymidine

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Show Links (1 entry)

ChEBI

PubChem

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