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Ligand (3S)-citryl-CoA Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C2 7 H4 2 N7 O2 2 P3 S
(3S)-citryl-CoA
IHVFHZGGMJDGGZ-VPXVXCNZSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(3S)-citryl-CoA = acetyl-CoA + oxaloacetate
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acetyl-CoA + citrate = acetate + (3S)-citryl-CoA
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ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA
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Substrate in Enzyme-catalyzed Reactions (1 result)
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(3S)-citryl-CoA = acetyl-CoA + oxaloacetate
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Product in Enzyme-catalyzed Reactions (5 results)
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acetyl-CoA + citrate = acetate + (3S)-citryl-CoA
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propionyl-CoA + citrate = propionate + (3S)-citryl-CoA
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butyryl-CoA + citrate = butyrate + (3S)-citryl-CoA
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ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA
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ATP + citrate + CoA = ADP + phosphate + citryl-CoA
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (2 results)
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KM Value (2 results)
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References & Links Literature References (7)
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Isolation of enzymically active fragments formed by limited proteolysis
1982
Lill, U.; Schreil, A.; Eggerer, H.
Eur. J. Biochem.
125
645-650
Citrate lyase from Klebsiella pneumoniae. The complete primary structure of the acyl lyase subunit
1990
Hupperich, M.; Henschen, A.; Eggerer, H.
Eur. J. Biochem.
192
161-166
Conversion of citrate synthase into citryl-CoA lyase as a result of mutation of the active-site aspartic acid residue to glutamic acid
1991
Man, W.J.; Li, Y.; O'Connor, C.D.; Wilton, D.C.
Biochem. J.
280
521-526
Characterization of the isolated transferase subunit of citrate lyase as a CoA-transferase. Evidence against a covalent enzyme-substrate intermediate
1977
Dimroth, P.; Loyal, R.; Eggerer, H.
Eur. J. Biochem.
80
479-488
A novel enzyme, citryl-CoA lyase, catalysing the second step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6
2004
Aoshima, M.; Ishii, M.; Igarashi, Y.
Mol. Microbiol.
52
763-770
Autotrophic CO2 fixation via the reductive tricarboxylic acid cycle in different lineages within the phylum Aquificae: Evidence for two ways of citrate cleavage
2007
Hugler, M.; Huber, H.; Molyneaux, S.J.; Vetriani, C.; Sievert, S.M.
Environ. Microbiol.
9
81-92
A phylogenetic approach to the early evolution of autotrophy the case of the reverse TCA and the reductive acetyl-CoA pathways
2014
Becerra, A.; Rivas, M.; Garcia-Ferris, C.; Lazcano, A.; Pereto, J.
Int. Microbiol.
17
91-97
Links to other databases for (3S)-citryl-CoA
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