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Ligand beta-D-ribosylnicotinate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C1 1 H1 3 NO6
beta-D-ribosylnicotinate
PUEDDPCUCPRQNY-ZYUZMQFOSA-N
icotinic acid ribonucleoside, nicotinate D-ribonucleoside, nicotinate riboside, nicotinic acid nucleoside, nicotinic acid riboside
Related pathways
MetaCyc
NAD salvage (plants)
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide
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Substrate in Enzyme-catalyzed Reactions (4 results)
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nicotinic acid nucleoside + benzimidazole = ?
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ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide
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GTP + beta-D-ribosylnicotinate = GDP + nicotinate beta-D-ribonucleotide
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nicotinic acid riboside + H2O = nicotinic acid + D-ribose
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Product in Enzyme-catalyzed Reactions (1 result)
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nicotinamide riboside + H2O = nicotinate riboside + NH3
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (7 results)
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0.21
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with ATP, pH and temperature not specified in the publication
0.34
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Nrk1, with GTP, pH 7.5, 37°C
0.34
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with ATP, pH and temperature not specified in the publication
0.6
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Nrk1, with ATP, pH 7.5, 37°C
0.75
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Nrk2, with ATP, pH 7.5, 37°C
1.7
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Nrk2, with GTP, pH 7.5, 37°C
1.8
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in 50 mM Tris-HCl, pH 7.0
KM Value (7 results)
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0.051
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with ATP, pH and temperature not specified in the publication
0.063
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with ATP, pH and temperature not specified in the publication
0.068
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Nrk1, with GTP, pH 7.5, 37°C
0.088
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Nrk1, with ATP, pH 7.5, 37°C
0.19
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Nrk2, with ATP, pH 7.5, 37°C
30
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Nrk2, with GTP, pH 7.5, 37°C
0.15
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in 50 mM Tris-HCl, pH 7.0
References & Links Literature References (6)
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Partial purification and properties of a single displacement trans-N-glycoside
1965
Friedmann, H.C.
J. Biol. Chem.
240
413-418
Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism
2009
Belenky, P.; Christensen, K.C.; Gazzaniga, F.; Pletnev, A.A.; Brenner, C.
J. Biol. Chem.
284
158-164
Nicotinate riboside salvage in plants: presence of nicotinate riboside kinase in mungbean seedlings
2008
Matsui, A.; Ashihara, H.
Plant Physiol. Biochem.
46
104-108
Nicotinamide riboside kinase structures reveal new pathways to NAD+
2007
Tempel, W.; Rabeh, W.M.; Bogan, K.L.; Belenky, P.; Wojcik, M.; Seidle, H.F.; Nedyalkova, L.; Yang, T.; Sauve, A.A.; Park, H.W.; Brenner, C.
PLoS Biol.
5
e263
Novel assay for simultaneous measurement of pyridine mononucleotides synthesizing activities allows dissection of the NAD+ biosynthetic machinery in mammalian cells
2014
Zamporlini, F.; Ruggieri, S.; Mazzola, F.; Amici, A.; Orsomando, G.; Raffaelli, N.
FEBS J.
281
5104-5119
The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism
2018
Fletcher, R.S.; Lavery, G.G.
J. Mol. Endocrinol.
61
R107-R121
Links to other databases for beta-D-ribosylnicotinate
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