print visible entries

print all entries

Ligand pimeloyl-[acyl-carrier protein]

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for pimeloyl-[acyl-carrier protein]

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.47

pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]

736946, 735394, 736245

-

2.6.1.62

pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]

756558

-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.46

a long-chain acyl-[acyl-carrier protein] + reduced flavodoxin + O2 = pimeloyl-[acyl-carrier protein] + an n-alkanal + oxidized flavodoxin + H2O

0

-

3.1.1.85

pimeloyl-[acyl-carrier protein] methyl ester + H2O = pimeloyl-[acyl-carrier protein] + methanol

0

-

Substrate in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.47

pimeloyl-[acyl carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + [acyl carrier protein]

755855

-

2.3.1.47

pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]

736946, 735394, 736245

-

2.3.1.47

2 entries

2.6.1.62

pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]

756558

-

Product in Enzyme-catalyzed Reactions (11 results)

top print hide

Show Product (11 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.46

tetradecanoyl-[acyl-carrier protein] + reduced flavodoxin + O2 = pimeloyl-[acyl carrier protein] + ?

0

-

1.14.14.46

(7R,8R)-7,8-dihydroxytetradecanoyl-[acyl carrier protein] + reduced flavodoxin + O2 = pimeloyl-[acyl-carrier protein] + ?

0

-

1.14.14.46

(7R,8S)-7,8-dihydroxytetradecanoyl-[acyl carrier protein] + reduced flavodoxin + O2 = pimeloyl-[acyl-carrier protein] + ?

0

-

1.14.14.46

7-hydroxytetradecanoyl-[acyl carrier protein] + reduced flavodoxin + O2 = pimeloyl-[acyl-carrier protein] + ?

0

-

1.14.14.46

7-oxotetradecanoyl-[acyl carrier protein] + reduced flavodoxin + O2 = pimeloyl-[acyl-carrier protein] + ?

0

-

1.14.14.46

a long-chain acyl-[acyl-carrier protein] + reduced flavodoxin + O2 = pimeloyl-[acyl-carrier protein] + an n-alkanal + oxidized flavodoxin + H2O

0

-

3.1.1.85

pimeloyl-[acyl-carrier protein] butyl ester + H2O = pimeloyl-[acyl-carrier protein] + butanol

0

-

3.1.1.85

pimeloyl-[acyl-carrier protein] ethyl ester + H2O = pimeloyl-[acyl-carrier protein] + ethanol

0

-

3.1.1.85

pimeloyl-[acyl-carrier protein] methyl ester + H2O = pimeloyl-[acyl-carrier protein] + methanol

0

-

3.1.1.85

pimeloyl-[acyl-carrier protein] propyl ester + H2O = pimeloyl-[acyl-carrier protein] + propanol

0

-

3.1.1.85

pimelyl-[acyl-carrier protein] methyl ester + H2O = pimelyl-[acyl-carrier protein] + methanol

0

-

1.14.14.46

6 entries

3.1.1.85

5 entries

Enzyme Kinetic Parameters

References & Links

Literature References (5)

top print hide

Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

735394

25286942

Purification and X-ray crystallographic analysis of 7-keto-8-aminopelargonic acid (KAPA) synthase from Mycobacterium smegmatis

2014

Fan, S.; Li, D.; Fleming, J.; Hong, Y.; Chen, T.; Zhou, L.; Bi, L.; Wang, D.; Zhang, X.; Chen, G.

Acta Crystallogr. Sect. F

70

1372-1375

736245

25462832

Structure and function of Mycobacterium smegmatis 7-keto-8-aminopelargonic acid (KAPA) synthase

2015

Fan, S.; Li, D.F.; Wang, D.C.; Fleming, J.; Zhang, H.; Zhou, Y.; Zhou, L.; Zhou, J.; Chen, T.; Chen, G.; Zhang, X.E.; Bi, L.

Int. J. Biochem. Cell Biol.

58

71-80

736946

26615154

Triazolyl phenyl disulfides: 8-amino-7-oxononanoate synthase inhibitors as potential herbicides

2015

Hahn, H.G.; Choi, J.S.; Lim, H.K.; Lee, K.I.; Hwang, I.T.

Pestic. Biochem. Physiol.

125

78-83

755855

29054876

A Canonical biotin synthesis enzyme, 8-amino-7-oxononanoate synthase (BioF), utilizes different acyl chain donors in Bacillus subtilis and Escherichia coli

2018

Manandhar, M.; Cronan, J.E.

Appl. Environ. Microbiol.

84

e02084-17

756558

28280303

In silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA)

2017

Billones, J.B.; Carrillo, M.C.; Organo, V.G.; Sy, J.B.; Clavio, N.A.; Macalino, S.J.; Emnacen, I.A.; Lee, A.P.; Ko, P.K.; Concepcion, G.P.

Drug Des. Devel. Ther.

11

563-574

Links to other databases for pimeloyl-[acyl-carrier protein]

top print hide

Show Links (1 entry)