Ligand ethylamine

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Basic Ligand Information

Molecular Structure
Picture of ethylamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H7N
ethylamine
QUSNBJAOOMFDIB-UHFFFAOYSA-N
Synonyms:
aminoethane, ethanamine, ethaneamine


Show all pahtways known for Show all BRENDA pathways known for ethylamine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ethylamine + H2O + O2 = acetaldehyde + NH3 + H2O2
show the reaction diagram
ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + H2O2
show the reaction diagram
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-
1,2-diaminoethane + pyruvate = aminoethane + alanine
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N5-ethyl-L-glutamine + H2O = L-glutamate + ethylamine
show the reaction diagram
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hydroxyatrazine + H2O = N-isopropylammelide + ethylamine
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Substrate in Enzyme-catalyzed Reactions (32 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ethylamine + NADH + H+ + O2 = ?
show the reaction diagram
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ethylamine + O2 + H2O = ?
show the reaction diagram
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ethylamine + H2O + O2 = ethanal + NH3 + H2O2
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ethylamine + acceptor + H2O = acetaldehyde + NH3 + reduced acceptor
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pyruvate + ethylamine + NADPH + H+ = N-ethyl-L-alanine + NADP+
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1-N-(carbobenzoxy-L-glutaminylglycyl)-5-N-(5'-N',N'-dimethylamino-1'-naphthalenesulfonyl)diamidopentane + ethylamine = ?
show the reaction diagram
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L-glutamine + ethylamine = theanine + NH3
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ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine
show the reaction diagram
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ATP + L-Glu + ethylamine = ADP + phosphate + N-ethyl-L-glutamine
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Product in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
diethylamine + NADH + H+ + O2 = ethylamine + acetaldehyde + NAD+ + H2O
show the reaction diagram
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N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + H2O2
show the reaction diagram
-
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diethylamine + H2O + phenazine methosulfate = ethylamine + acetaldehyde + reduced phenazine methosulfate
show the reaction diagram
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N-(gamma-L-glutamyl)ethylamine + H2O = L-glutamate + ethylamine
show the reaction diagram
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1,2-diaminoethane + pyruvate = aminoethane + alanine
show the reaction diagram
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taurine + ethanal = 2-sulfoacetaldehyde + ethylamine
show the reaction diagram
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beta-aspartomethylamide + H2O = L-Asp + ethylamine
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N-ethylcaproamide + H2O = ethylamine + hexanoate
show the reaction diagram
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ethyl acetate + H2O = acetic acid + ethaneamine
show the reaction diagram
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N-ethylformamide + H2O = ethylamine + formate
show the reaction diagram
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ethylguanidine + H2O = ethylamine + urea
show the reaction diagram
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N-ethylammelide + H2O = cyanuric acid + ethylamine
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Ala = Ethylamine + CO2
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(2S)-N-ethylaspartic acid = fumarate + ethylamine
show the reaction diagram
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5-L-glutamyl-ethylamine = 5-oxoproline + ethylamine
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Activator in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation of enzyme from K176A mutant
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mutant K212Q, 4fold activation compared to the wild-type enzyme
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inhibitory at high concentrations
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5 mM, wild-type enzyme shows strict dependence on an activator
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30% activation, Pseudomonas sp. strain No. 43
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alphaH44A mutant, works as catalytic base
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little ADH I activity is detected in the absence of ethylamine or ammonium ions
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saturating ethylamine accelerates the L-alanine reaction 70fold
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slight activation of mutant K202A
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Inhibitor in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activating at low concentrations, inhibitory at high concentrations
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noncompetitive product inhibition with respect to phenazine methosulfate
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inhibition of wild-type enzyme
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500 mM, 73% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (12 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (14 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
11.1
-
-
0.00055
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1-N-(carbobenzoxy-L-glutaminylglycyl)-5-N-(5'-N',N'-dimethylamino-1'-naphthalenesulfonyl)diamidopentane as glutamine donor

KM Value (20 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.041
-
at pH 6.8 and 28°C
66
-
at pH 7.4
0.31
-
-

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
112.5
-
pH 9.0, temperature not specified in the publication
11
-
pH 8.0, 25°C
2.3
-
-
460
-
substrate 4-nitrophenyl-beta-D-xylopyranoside, 25°C, pH 7.0

References & Links

Links to other databases for ethylamine

ChEBI
PubChem
ChEBI
PubChem