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Ligand Galbeta1-4(Fucalpha1-3)GlcNAc Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C2 0 H3 5 NO1 5
Galbeta1-4(Fucalpha1-3)GlcNAc
HBBOZFUQJDYASD-LPHOMBEVSA-N
3-fucosyl-N-acetyllactosamine, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc, Galbeta(1,4)(Fucalpha(1,3))GlcNAc, Galbeta1-4 (Fucalpha1-3)GlcNAc, Lewis X trisaccharide
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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Lewis X trisaccharide + H2O = ?
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Product in Enzyme-catalyzed Reactions (6 results)
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GDP-L-fucose + Galbeta(1,4)GlcNAc = GDP + Galbeta(1,4)(Fucalpha(1,3))GlcNAc
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GDP-fucose + Galbeta1-4GlcNAc = GDP + Galbeta1-4 (Fucalpha1-3)GlcNAc
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GDP-beta-fucose + lacto-N-neotetraose = GDP + Galbeta1-4(Fucalpha1-3)GlcNAc
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GDP-fucose + N-acetyllactosamine = GDP + Galbeta1-4(Fucalpha1-3)GlcNAc
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GDP-fucose + Gal-beta-1,4GlcNAc = GDP + Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc + Gal-beta-1,4(Fuc-alpha-1,2)GlcNAc
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GDP-L-fucose + Galbeta(1,4)GlcNAc = GDP + Galbeta(1,4)(Fucalpha(1,3))GlcNAc
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (9 results)
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0.078
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mutant enzyme E315A, at pH 4.6 and 37°C
0.082
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mutant enzyme D242A, at pH 4.6 and 37°C
0.23
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mutant enzyme E302A, at pH 4.6 and 37°C
9.075
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mutant enzyme C317A, at pH 4.6 and 37°C
21.55
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wild type enzyme, at pH 4.6 and 37°C
23.83
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mutant enzyme 249DELTA265, at pH 4.6 and 37°C
25.43
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mutant enzyme C467S, at pH 4.6 and 37°C
29.07
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mutant enzyme C317S, at pH 4.6 and 37°C
34.47
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mutant enzyme C73S, at pH 4.6 and 37°C
KM Value (9 results)
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1.3
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wild type enzyme, at pH 4.6 and 37°C
1.5
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mutant enzyme C467S, at pH 4.6 and 37°C
2.6
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mutant enzyme C73S, at pH 4.6 and 37°C
2.8
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mutant enzyme E315A, at pH 4.6 and 37°C
3.3
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mutant enzyme C317A, at pH 4.6 and 37°C
4.1
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mutant enzyme C317S, at pH 4.6 and 37°C
9.7
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mutant enzyme D242A, at pH 4.6 and 37°C
12.8
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mutant enzyme E302A, at pH 4.6 and 37°C
13.2
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mutant enzyme 249DELTA265, at pH 4.6 and 37°C
References & Links Literature References (3)
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Purification and characterization of GDP-L-Fuc-N-acetyl-beta-D-glucosaminide alpha1,3 fucosyltransferase from human neuroblastoma cells. Unusual substrate specificities of the tumor enzyme
1991
Foster, C.S.; Gillies, D.R.B.; Glick, M.C.
J. Biol. Chem.
266
3526-3531
Identification of a GDP-Fuc:Gal beta 1-3GalNAc-R (Fuc to Gal) alpha 1-2 fucosyltransferase and a GDP-Fuc:Gal beta 1-4GlcNAc (Fuc to GlcNAc) alpha 1-3 fucosyltransferase in connective tissue of the snail Lymnaea stagnalis
1996
Mulder, H.; Schachter, H.; Thomas, J.R.; Halkes, K.M.; Kamerling, J.P.; Vliegenthart, J.F.
Glycoconjugate J.
13
107-113
Identification and characterization of a core fucosidase from the bacterium Elizabethkingia meningoseptica
2018
Li, T.; Li, M.; Hou, L.; Guo, Y.; Wang, L.; Sun, G.; Chen, L.
J. Biol. Chem.
293
1243-1258
Links to other databases for Galbeta1-4(Fucalpha1-3)GlcNAc
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