Ligand angiotensin I

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of angiotensin I (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C62H89N17O14
angiotensin I
ORWYRWWVDCYOMK-HBZPZAIKSA-N
Synonyms:
angiotensin, angiotensin-I, angiotensin 1, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, DRVYIHPFHL, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
angiotensin + H2O = Asp + des-Asp-angiotensin
show the reaction diagram
-
angiotensin I + H2O = ?
show the reaction diagram
-
angiotensin I + H2O = angiotensin II + ?
show the reaction diagram
-
angiotensin I + H2O = ?
show the reaction diagram
-
angiotensin I + H2O = ?
show the reaction diagram
-
angiotensin I + H2O = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
angiotensinogen + H2O = angiotensin I + ?
show the reaction diagram
-
-
angiotensinogen + H2O = angiotensin I + angiotensinogen propeptide
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (60 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
angiotensin I + H2O = ? + phosphate
show the reaction diagram
-
DRVYIHPFHL + H2O = L-Asp + L-Arg + VYIHPFHL
show the reaction diagram
-
DRVYIHPFHL + H2O = DRV + YIHPFHL
show the reaction diagram
-
angiotensin I + H2O = DRVYIHPF + His-Leu
show the reaction diagram
-
angiotensin 1 + H2O = ?
show the reaction diagram
-
angiotensin I + H2O = angiotensin II + ?
show the reaction diagram
-
angiotensin I + H2O = ?
show the reaction diagram
-
angiotensin I + H2O = ?
show the reaction diagram
-
angiotensin + H2O = ?
show the reaction diagram
-
angiotensin + H2O = ?
show the reaction diagram
-
angiotensin + H2O = ?
show the reaction diagram
-
angiotensin I + H2O = hydrolyzed angiotensin I
show the reaction diagram
-
angiotensin + H2O = ?
show the reaction diagram
-
angiotensin I + H2O = ?
show the reaction diagram
-
angiotensin I + H2O = ?
show the reaction diagram
-
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + H2O = Asp-Arg-Val-Tyr-Ile-His-Pro + Phe-His-Leu
show the reaction diagram
-
angiotensin I + H2O = DRVY + IHPFLHL + DRVYI + HPFHL
show the reaction diagram
-
angiotensin I + H2O = Asp-Arg-Val-Tyr-Ile-His + Pro + Phe-His-Leu
show the reaction diagram
-
angiotensin + H2O = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phospho-Tyr angiotensin + H2O = angiotensin + phosphate
show the reaction diagram
-
-
DRVpYIHPFHL + H2O = DRVYIHPFHL + phosphate
show the reaction diagram
-
-
angiotensin-(1-12) + H2O = angiotensin I + ?
show the reaction diagram
-
-
angiotensinogen + H2O = angiotensin I + ?
show the reaction diagram
-
-
angiotensinogen + H2O = angiotensin
show the reaction diagram
-
-
Synthetic tetradecapeptide renin substrate + H2O = Angiotensin I
show the reaction diagram
-
Human renin substrate + H2O = Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + Val-Ile-His
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at 0.1 mM concentration
-
causes an increase in expression of isozyme cGKIbeta, and a decrease in expression of isozyme cGKIalpha
-

Inhibitor in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
angiotensin-(1-7) decreases the elevated levels of renal NADPH oxidase activity and attenuates the activation of subunit NOX-4 gene expression in the diabetic hypertensive kidney. Angiotensin-(1-7) treatment increases sodium excretion but does not affect mean arterial pressure in diabetic hypertensive rats. The significant increase in urinary protein in the diabetic compared to control hypertensive rat is reduced by angiotensin-(1-7). Angiotensin-(1-7) treatment also attenuates the diabetes-induced increase in renal vascular responsiveness to endothelin-1, norepinephrine, and angiotensin II in hypertensive rats, but significantly increases the vasodilation of the renal artery of hypertensive and diabetic hypertensive rats to the vasodilator agonists
-
causes a decrease in expression of isozyme cGKIalpha, and an increase in expression of isozyme cGKIbeta
-
inhibits the mutant DELTA317-496 in a dose-dependent manner
-
inhibits hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (33 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
8.23
-
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.5, at 37°C
0.85
-
-
3
-
37°C

KM Value (40 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.064
-
-
0.016
-
-

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.000002747
-
-
0.0022
-
-
0.036
-
hydrolysis of Leu5-enkephalin
0.00429
-
inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)
0.00535
-
inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for angiotensin I

ChEBI
PubChem
-
PubChem