Ligand 2,3-diphosphoglycerate

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Basic Ligand Information

Molecular Structure
Picture of 2,3-diphosphoglycerate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H8O10P2
2,3-diphosphoglycerate
XOHUEYCVLUUEJJ-UHFFFAOYSA-N
Synonyms:
2,3 diphosphoglycerate, 2,3-bisphosphoglycerate, 2,3-bisphosphoglyceric acid, 2,3-diphosphoglyceric acid, glycerate 2,3-diphosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-phospho-D-glycerate + 2,3-bisphosphoglycerate = 3-phospho-D-glycerate + 2,3-bisphosphoglycerate
show the reaction diagram
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2,3-Diphosphoglycerate = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cyclic 2,3-bisphosphoglycerate + H2O = 2,3-diphosphoglycerate
show the reaction diagram
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-
2-phospho-D-glycerate + 2,3-bisphosphoglycerate = 3-phospho-D-glycerate + 2,3-bisphosphoglycerate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,3-diphosphoglycerate + H2O = ?
show the reaction diagram
-
2,3-diphosphoglycerate + H2O = ?
show the reaction diagram
-
2,3-diphosphoglycerate + H2O = ?
show the reaction diagram
-
2,3-bisphosphoglycerate + H2O = ?
show the reaction diagram
-
2,3-diphosphoglycerate + H2O = ?
show the reaction diagram
-
2,3-bisphosphoglycerate + H2O = 2-phosphoglycerate + phosphate
show the reaction diagram
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2-phospho-D-glycerate + 2,3-bisphosphoglycerate = 3-phospho-D-glycerate + 2,3-bisphosphoglycerate
show the reaction diagram
-
2,3-Diphosphoglycerate = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cyclic 2,3-bisphosphoglycerate + H2O = 2,3-diphosphoglycerate
show the reaction diagram
-
-
2-phospho-D-glycerate + 2,3-bisphosphoglycerate = 3-phospho-D-glycerate + 2,3-bisphosphoglycerate
show the reaction diagram
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1,3-Diphosphoglycerate = 2,3-Diphosphoglycerate
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (29 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates both isoenzymes up to 200% of their original activity
-
stimulates
-
the 1 M 2,3-diphosphoglycerate the enzyme is highly active
-
low concentrations
-
activation
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Inhibitor in Enzyme-catalyzed Reactions (38 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
5 mM, 30% inhibition
-
high concentrations
-
product inhibition
-
ATP counteracts inhibition
-
product inhibition
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (14 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.09
-
-
27
-
-
0.5
-
25°C, pH 5.6
0.61
-
recombinant enzyme, at 37°C

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.35
-
-
1.1
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
1.1
-
inhibits in the millimolar range, IC50: 1.1 mM with rhodopsin as substrate

References & Links

Links to other databases for 2,3-diphosphoglycerate

ChEBI
PubChem
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PubChem