Ligand p-mercuribenzoate

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Basic Ligand Information

Molecular Structure

C₇H₅HgO₂

p-mercuribenzoate

MGMQAZXDRJETOM-UHFFFAOYSA-N

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Synonyms:

4-mercuribenzoate, mercuribenzoate, mercuribenzoic acid, p-mercuribenzoic acid, PMB

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Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (2 results)

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2.3.1.29

486740

3.1.3.11

up to 90% inhibition at pH 6.5-7.0, slight increase of activity at pH 9.0 when Mg2+ is the metal cofactor. 3fold increase of activity at alkaline pH, less activation at neutral pH when Mn2+ is the metal cofactor

170763

Inhibitor in Enzyme-catalyzed Reactions (102 results)

79% inhibition of NAD dehydrogenase II at 0.014 mM

286004

1.1.1.151

55% inhibition at 0.014 mM

286004

1.1.1.153

0.1 mM, 93% inhibition

strong

reversible by L-cysteine

287124

1.1.1.8

0.1 mM complete inhibition

287331

1.1.1.B51

1 mM, complete inhibition

one Cys residue reacts rapidly without loss of enzyme activity, three sulfhydryl groups then react in an 'all or none process' involving enzyme inactivation and dissociation of the octamer into dimers, antichaotropic salts protect from mercuration

10668

1.10.3.3

some authors report inhibition, others do not

80% inhibition at 0.05 mM

99% inhibition at 0.1 mg/ml

743751

1.7.1.7

2 mM, complete inhibition, complete protection by 2 mM GSH

0.01 mM, 50% inhibition

485858

2.3.1.26

100% inhibition of liver and aortic enzyme at 1 mM

reversible by dithioerythritol, substrates protect, serine and alanine protect

487365

2.3.1.95

inactivation, reactivation by excess of dithiothreitol

strong inhibition

strong, 0.007 mM: 50% inhibition

489281

2.4.1.66

0.0007 mM: 50% inhibition, substrates plus Mn2+ or Mn2+ alone partially protect

636777

2.4.2.14

0.001 mM, complete inhibition

formate kinase I and II

642342

2.7.7.49

0.02 mM, 96% loss of activity

48.8% residual activity at 1 mM

691358

3.1.1.60

complete inhibition at 1 mM, 80% inhibition at 0.1 mM

170988

3.1.3.11

up to 90% inhibition at pH 6.5-7.0, slight increase at pH 9.0 when Mg2+ is the metal cofactor. 3fold increase of activity at alkaline pH, less activation at neutral pH when Mn2+ is the metal cofactor

170763

3.1.3.18

the inhibition is recovered by addition of dithiothreitol

complete inhibition at 0.25 mM

1 mM, 23% inhibition

10 mM, 16.08% of initial activity

775437

3.2.1.8

5 mM, 40% inhibition of enzyme component I of strain W1 and W2

1 mM, 85% inhibition

0.1 mM

kidney enzyme

complete loss of activity

enzyme activity increases until 40% of SH-groups are titrated, complete inhibition when all SH-groups are titrated

3D Structure of Enzyme-Ligand-Complex (PDB) (517 results)

Enzyme Kinetic Parameters

K_i Value (1 result)

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3.5.4.1

0.3

209484

References & Links

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Show Reference (111 entries)

Links to other databases for p-mercuribenzoate

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PubChem

UniChem

Ligand p-mercuribenzoate

Basic Ligand Information

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (2 results)

Inhibitor in Enzyme-catalyzed Reactions (102 results)

3D Structure of Enzyme-Ligand-Complex (PDB) (517 results)

Enzyme Kinetic Parameters

Ki Value (1 result)

References & Links

Literature References (111)

Links to other databases for p-mercuribenzoate

K_i Value (1 result)