Ligand isopropylmalate

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Basic Ligand Information

Molecular Structure
Picture of isopropylmalate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H12O5
isopropylmalate
FTNIPWXXIGNQQF-FFFJRYSISA-N
Synonyms:
(2R,3R)/(2S,3S)-3-isopropylmalate, (3S)-isopropylmalate, 3-Carboxy-2-hydroxy-4-methylpentanoate, 3-isopropylmalate, alpha-hydroxy-beta-carboxyisocaproate, alpha-isopropylmalate, beta-isopropylmalate, DL-3-isopropylmalate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-isopropylmalate + NAD+ = 2-ketoisocaproate + CO2 + NADH + H+
show the reaction diagram
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3-isopropylmalate + NAD+ = ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + alpha-ketoisovalerate + H2O = alpha-isopropylmalate + CoA
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
isopropylmalate + NADP+ = ?
show the reaction diagram
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isopropylmalate + NAD+ = ?
show the reaction diagram
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S-adenosyl-L-methionine + (2R,3R)/(2S,3S)-3-isopropylmalate = S-adenosyl-L-homocysteine + ?
show the reaction diagram
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(3S)-isopropylmalate = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxoisovalerate + acetyl-CoA = isopropylmalate + CoA
show the reaction diagram
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2-isopropylmaleate + H2O = 3-isopropylmalate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive against both 2-oxo-3-methylbutanoate and acetyl-CoA
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (35 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.00001
-
smaller than 0.00001 s-1

KM Value (51 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.428
-
-

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for isopropylmalate

ChEBI
PubChem
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PubChem