Ligand gastrin 17
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Basic Ligand Information
Molecular Structure
C88H116N18O32S
gastrin 17
ONBHLCUYURAANP-CHLXADDNSA-N
gastrin-17, gastrin G-17, gastrin I, heptadecapeptide gastrin
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (3 results)
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Product in Enzyme-catalyzed Reactions (1 result)
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progastrin + H2O = gastrin-34 + gastrin-17
-
-
Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (7 results)
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10.8
-
pH 7.5, 37°C, mutant Y199K
10.5
-
pH 7.5, 37°C, 500 mM NaCl, mutant K185Y
11
-
pH 7.5, 37°C, 150 mM NaCl
11.1
-
pH 7.5, 37°C, 500 mM NaCl
17.8
-
pH 7.5, 37°C, 150 mM NaCl, mutant K185Y
KM Value (7 results)
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0.44
-
pH 7.5, 37°C, mutant Y199K
0.00104
-
pH 7.5, 37°C, 150 mM NaCl
0.0185
-
pH 7.5, 37°C, 500 mM NaCl
0.02
-
pH 7.5, 37°C, 150 mM NaCl, mutant K185Y
0.0296
-
pH 7.5, 37°C, 500 mM NaCl, mutant K185Y
References & Links
Literature References (5)
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Enkephalin-degrading dipeptidyl carboxypeptidase in guinea pig serum: its properties and action on bioactive peptides
1985
Kase, R.; Hazato, T.; Shimamura, M.; Kiuchi, Y.; Katayama, T.
Arch. Biochem. Biophys.
240
330-336
Degradation of human gastrin and CCK by endopeptidase 24.11: differential behaviour of the sulphated and unsulphated peptides
1989
Pauwels, S.; Najdovski, T.; Dimaline, R.; Lee, C.M.; Deschodt-Lanckman, M.
Biochim. Biophys. Acta
996
82-88
Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones
1989
Erdös, E.G.; Skidgel, R.A.
FASEB J.
3
145-151
Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity
2001
Bertenshaw, G.P.; Turk, B.E.; Hubbard, S.J.; Matters, G.L.; Bylander, J.E.; Crisman, J.M.; Cantley, L.C.; Bond, J.S.
J. Biol. Chem.
276
13248-13255
Critical Amino Acids in the Active Site of Meprin Metalloproteinases for Substrate and Peptide Bond Specificity
2003
Villa, J.P.; Bertenshaw, G.P.; Bond, J.S.
J. Biol. Chem.
278
42545-42550
Links to other databases for gastrin 17
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