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Ligand L-3,4-dihydroxyphenylalanine methyl ester

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.10.3.1

L-3,4-dihydroxyphenylalanine methyl ester + 1/2 O2 = L-dopaquinone methyl ester + H2O

675458

-

1.14.18.1

3,4-dihydroxyphenylalanine methyl ester + O2 = ?

636402

-

1.14.18.1

L-dopa methyl ester + O2 = ?

745746

-

1.14.18.1

2 entries

5.3.3.12

L-3,4-dihydroxyphenylalanine methyl ester = methyl 3-(3,4-dioxocyclohexa-1,5-dien-1-yl)-L-alaninate

702139, 702357

-

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.18.1

L-tyrosine methyl ester + O2 + AH2 = L-dopa methyl ester + H2O + A

0

-

1.14.18.1

L-tyrosine methyl ester + O2 = L-DOPA methyl ester + H2O

0

-

1.14.18.1

2 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (3 results)

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Show Turnover Number (3 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.10.3.1

35.5

-

-

675458

1.14.18.1

57

-

recombinant enzyme, pH 7.2, 37°C

745746

1.14.18.1

187

-

recombinant enzyme, pH 7.2, 37°C

745746

1.14.18.1

2 entries

K_M Value (4 results)

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Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.10.3.1

0.57

-

-

675458

1.14.18.1

0.046

-

-

636402

1.14.18.1

1.9

-

recombinant enzyme, pH 7.2, 37°C

745746

1.14.18.1

4.2

-

recombinant enzyme, pH 7.2, 37°C

745746

1.14.18.1

3 entries

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

636402

415664

Mammalian tyrosinase: isolation by a simple new procedure and characterization of its steric requirements for cofactor activity

1978

Hearing, V.J.; Ekel, T.M.; Montague, P.M.; Hearing, E.D.; Nicholson, J.M.

Arch. Biochem. Biophys.

185

407-418

675458

-

Kinetic study of monophenol and o-diphenol binding to oxytyrosinase

2005

Garcia-Molina, F.; Penalver, M.J.; Fenoll, L.G.; Rodriguez-Lopez, J.N.; Varon, R.; Gracia-Canovas, F.; Tudela, J.

J. Mol. Catal. B

32

185-192

702139

19723024

Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)

2009

Cross, J.V.; Rady, J.M.; Foss, F.W.; Lyons, C.E.; Macdonald, T.L.; Templeton, D.J.

Biochem. J.

423

315-321

702357

19737008

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

2009

Ouertatani-Sakouhi, H.; El-Turk, F.; Fauvet, B.; Roger, T.; Le Roy, D.; Karpinar, D.P.; Leng, L.; Bucala, R.; Zweckstetter, M.; Calandra, T.; Lashuel, H.A.

Biochemistry

48

9858-9870

745746

25189462

Human tyrosinase produced in insect cells a landmark for the screening of new drugs addressing its activity

2015

Fogal, S.; Carotti, M.; Giaretta, L.; Lanciai, F.; Nogara, L.; Bubacco, L.; Bergantino, E.

Mol. Biotechnol.

57

45-57

Links to other databases for L-3,4-dihydroxyphenylalanine methyl ester

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Show Links (1 entry)

ChEBI

PubChem