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Ligand ubiquinone-4 Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C2 9 H4 2 O4
ubiquinone-4
XGCJRRDNIMSYNC-INVBOZNNSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (3 results)
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L-dihydroorotate + ubiquinone-4 = orotate + reduced ubiquinone-4
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reduced electron-transferring flavoprotein + ubiquinone-4 = electron-transferring flavoprotein + ubiquinol-4
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sulfide + ubiquinone-4 = sulfur + ubiquinol-4
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Product in Enzyme-catalyzed Reactions (1 result)
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ubiquinol 4 + cytochrome c = ubiquinone 4 + reduced cytochrome c
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Enzyme Cofactor/Cosubstrate (2 results)
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efficient, N-terminally truncated protein
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0.2 mM quinone stimulates reaction with D-alanine and oxidized 2,6-dichloroindophenol 3fold
-
Enzyme Kinetic Parameters
kcat Value (Turnover Number) (2 results)
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1.8
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pH 8.0, 25°C, cosubstrate L-dihydroorotate, N-terminally truncated protein
KM Value (4 results)
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0.035
-
pH 8.0, 25°C, cosubstrate L-dihydroorotate, N-terminally truncated protein
0.0016
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in 50 mM Tris-HCl, pH 7.4, 40°C
0.0016
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pH 7.4, temperature not specified in the publication
References & Links Literature References (4)
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Expression of human electron transfer flavoprotein-ubiquinone oxidoreductase from baculovirus vector: kinetic and spectral characterization of the human protein
2002
Simkovic, M.; Degala, G.D.; Eaton, S.S.; Frerman, F.E.
Biochem. J.
364
659-667
Purification and properties of D-amino acid dehydrogenase, an inducible membrane-bound iron-sulfur flavoenzyme from Escherichia coli B
1980
Olsiewski, P.J.; Kaczorowski, G.J.; Walsh, C.
J. Biol. Chem.
255
4487-4494
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity
2002
Baldwin, J.; Farajallah, A.M.; Malmquist, N.A.; Rathod, P.K.; Phillips, M.A.
J. Biol. Chem.
277
41827-41834
Characterizing a monotopic membrane enzyme. Biochemical, enzymatic and crystallization studies on Aquifex aeolicus sulfide:quinone oxidoreductase
2010
Marcia, M.; Langer, J.D.; Parcej, D.; Vogel, V.; Peng, G.; Michel, H.
Biochim. Biophys. Acta
1798
2114-2123
Links to other databases for ubiquinone-4
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