Ligand glucose 1-phosphate

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Basic Ligand Information

Molecular Structure
Picture of glucose 1-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13O9P
glucose 1-phosphate
HXXFSFRBOHSIMQ-GASJEMHNSA-N
Synonyms:
a monosaccharide 1-phosphate, D-glucose-1-phosphate, D-glucose 1-phosphate, Glc-1-phosphate, Glucose-1-phosphate
Pathway Source
Pathways
MetaCyc
CDP-4-dehydro-3,6-dideoxy-D-glucose biosynthesis, CDP-6-deoxy-D-gulose biosynthesis, chitin biosynthesis, D-galactose degradation I (Leloir pathway), dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for glucose 1-phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + D-glucose 1-phosphate = ADP + D-glucose 1,6-bisphosphate
show the reaction diagram
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate = 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
show the reaction diagram
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CTP + D-glucose 1-phosphate = ?
show the reaction diagram
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D-glucose 1-phosphate + H2O = D-glucose + phosphate
show the reaction diagram
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D-glucose 1-phosphate + H2O = D-glucose + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
sucrose + phosphate = D-fructose + D-glucose 1-phosphate
show the reaction diagram
-
-
phosphoramidate + D-glucose = D-glucose 1-phosphate + NH3
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (72 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glucose 1-phosphate + acceptor = 3-keto-D-glucose 1-phosphate + reduced acceptor
show the reaction diagram
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1,5-anhydroglucitol + glucose-1-phosphate = ?
show the reaction diagram
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glucose-1-phosphate + arsenate = glucose-1-arsenate + phosphate
show the reaction diagram
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ATP + D-glucose 1-phosphate = ADP + D-glucose 1,6-bisphosphate
show the reaction diagram
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate = 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
show the reaction diagram
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D-glucose 1-phosphate + D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate
show the reaction diagram
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D-glucose + D-glucose 1-phosphate = D-glucose 6-phosphate + D-glucose
show the reaction diagram
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D-glucose 1-phosphate + UTP = UDP-D-glucose + diphosphate
show the reaction diagram
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GTP + D-glucose 1-phosphate = diphosphate + GDP-glucose
show the reaction diagram
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CTP + D-glucose 1-phosphate = ?
show the reaction diagram
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ATP + D-glucose 1-phosphate = diphosphate + GDP-D-glucose
show the reaction diagram
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D-glucose 1-phosphate + H2O = D-glucose + phosphate
show the reaction diagram
-
D-glucose-1-phosphate + H2O = D-glucose + phosphate
show the reaction diagram
-
D-glucose 1-phosphate + H2O = D-glucose + phosphate
show the reaction diagram
-
glucose 1-phosphate + H2O = glucose + phosphate
show the reaction diagram
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D-glucose-1-phosphate + H2O = D-glucose + phosphate
show the reaction diagram
-
D-glucose 1-phosphate + H2O = ?
show the reaction diagram
-
D-glucose-1-phosphate + H2O = D-glucose + phosphate
show the reaction diagram
-
D-glucose 1-phosphate = D-glucose 6-phosphate
show the reaction diagram
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Glucose 1-phosphate = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (42 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cellobiose + phosphate = D-glucose 1-phosphate + D-glucose
show the reaction diagram
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-
sucrose + phosphate = D-fructose + D-glucose 1-phosphate
show the reaction diagram
-
-
ATP + D-glucose = ADP + D-glucose 1-phosphate
show the reaction diagram
-
-
phosphoramidate + D-glucose = D-glucose 1-phosphate + NH3
show the reaction diagram
-
UDP-glucose + D-galactose 1-phosphate = D-glucose 1-phosphate + UDP-galactose
show the reaction diagram
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-
GDP-glucose + diphosphate = D-glucose 1-phosphate + GTP
show the reaction diagram
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diphosphate + UDP-glucose = UTP + D-glucose 1-phosphate
show the reaction diagram
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diphosphate + UDP-D-glucose = UTP + D-glucose 1-phosphate
show the reaction diagram
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UDP-glucose + H2O = glucose-1-phosphate + 5'-UMP
show the reaction diagram
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Glucose 6-phosphate = Glucose 1-phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (28 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
-
production of a broad spectrum of MOSs (G4-G19) is stimulated both by phosphate and alpha-D-glucose 1-phosphate
-
10 mM, activates
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activation
-
2 mM, 30°C, pH 7.8, 3.8fold activation
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activates
-
stimulates
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Inhibitor in Enzyme-catalyzed Reactions (36 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
25.5% inhibition at 50 mM
-
a substrate-competitive inhibitor, that lowers the dissociation constant and maximum fluorescence quenching for NAD+ but not for NADP+
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substrate inhibition above 4 mM
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slight inhibition
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weak
-
allosteric inhibitor with a 40% reduction in the Vmax
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72% activity sustained, effector concentration 5 mM, 55°C
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inhibits by binding to one subunit of phosphorylase a
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complete inhibition of hydrolysis of glucose 6-phosphate as long as glucose 1-phosphate to glucose 6-phosphate ratios are greater than 0.12
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10 mM, 82% of initial activity
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95% residual activity at 2 mM
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partial inhibition of minor enzyme form, no effect on major enzyme form
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5 mM, 10% inhibition
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competitive
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competitive inhibition
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substrate inhibition of reverse reaction
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (26 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.32
-
pH 7.0, 37°C
50
-
-

KM Value (114 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4.7
-
with cellobiose
12
-
-
2.85
-
pH 7.5, 37°C, cosubstrate GTP
5.8
-
pH 7.5, 37°C, 5 mM UTP
0.346
-
pH 7.0, 37°C
24.4
-
-
0.24
-
25°C, pH 5.6

Ki Value (9 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
120
-
80°C, pH 5.0
3.2
-
-
120
-
-
2.5
-
pH 7.5, 37°C
3.3
-
25°C, pH 7.6, substrate inhibition at high concentrations

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
5
-
pH 7.5, 30°C
0.0063
-
versus N-acetyl-D-glucosamine 6-phosphate, pH 7.3, 37°C

References & Links

Links to other databases for glucose 1-phosphate

ChEBI
PubChem
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PubChem