Ligand GD1a

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Basic Ligand Information

Molecular Structure
Picture of GD1a (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C84H148N4O39
GD1a
RXIWRIRPTSKUTD-BFJDPXHSSA-N
Synonyms:
disialoganglioside GD1a, ganglioside GD1a, N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1>4)-beta-D-glucosyl-(1<->1)-ceramide, N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CMP-N-acetyl-beta-neuraminate + ganglioside GD1a = CMP + ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CMP-N-acetyl-beta-neuraminate + ganglioside GM1a = CMP + ganglioside GD1a
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + ganglioside GD1a = CoA + 4-O-acetylganglioside GD1a
show the reaction diagram
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acetyl-CoA + ganglioside GD1a = CoA + O-acetyl-ganglioside GD1a
show the reaction diagram
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CMP-N-acetyl-beta-neuraminate + ganglioside GD1a = CMP + ?
show the reaction diagram
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CMP-N-acetylneuraminate + disialoganglioside GD1a = CMP + trisialoganglioside GT1a
show the reaction diagram
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ganglioside GD1a + H2O = ?
show the reaction diagram
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ganglioside GD1a + H2O = fatty acid + lyso-GD1a-ganglioside
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CMP-N-acetyl-beta-neuraminate + ganglioside GM1a = CMP + ganglioside GD1a
show the reaction diagram
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CMP + trisialoganglioside GT1a = CMP-N-acetylneuraminate + disialoganglioside GD1a
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
exogenous ganglioside, slight inhibition, inhibition in vivo
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Enzyme Kinetic Parameters

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for GD1a

ChEBI
PubChem
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PubChem