Ligand 1,2-dilinoleoyl-sn-glycero-3-phosphocholine
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Basic Ligand Information
C44H80NO8P
1,2-dilinoleoyl-sn-glycero-3-phosphocholine
FVXDQWZBHIXIEJ-LNDKUQBDSA-O
1,2-di-linoleoyl-sn-glycero-3-phosphorylcholine, 1,2-dilinoleoyl-phosphatidylcholine, 1,2-linoleoylphosphatidylcholine
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (5 results)
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1,2-dilinoleoyl-phosphatidylcholine + O2 = ?
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1,2-dilinoleoyl-sn-glycero-3-phosphocholine + O2 = ?
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1,2-dilinoleoyl-phosphatidylcholine + H2O = 1-linoleoyl-glycerophosphorylcholine + linoleic acid
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1,2-dilinoleoyl-phosphatidylcholine + H2O = 1-linoleoyl-sn-glycero-3-phosphocholine + linoleic acid
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1,2-dilinoleoyl-sn-glycero-3-phosphocholine + H2O = 1-linoleoyl-sn-glycero-3-phosphocholine + linoleoate
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Product in Enzyme-catalyzed Reactions (3 results)
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1,2-di-oleoyl-sn-glycero-3-phosphorylcholine + 2 ferrocytochrome b5 + O2 + 2 H+ = 1,2-di-linoleoyl-sn-glycero-3-phosphorylcholine + 2 ferricytochrome b5 + 2 H2O
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1,2-dioleoylphosphatidylcholine + 2 ferrocytochrome b5 + O2 + 2 H+ = 1,2-linoleoylphosphatidylcholine + 2 ferricytochrome b5 + 2 H2O
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linoleoyl-CoA + 1-linoleoyl-sn-glycero-3-phosphocholine = CoA + 1,2-dilinoleoyl-sn-glycero-3-phosphocholine
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3D Structure of Enzyme-Ligand-Complex (PDB) (8 results)
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Enzyme Kinetic Parameters
KM Value (1 result)
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0.0175
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pH 8.0, 25°C, recombinant enzyme
References & Links
Literature References (5)
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Secretory phospholipase A2-alpha from Arabidopsis thaliana: functional parameters and substrate preference
2007
Mansfeld, J.; Ulbrich-Hofmann, R.
Chem. Phys. Lipids
150
156-166
On the singular, dual, and multiple positional specificity of manganese lipoxygenase and its G316A mutant
2007
Cristea, M.; Oliw, E.H.
J. Lipid Res.
48
890-903
Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)
2008
Duncan, R.E.; Sarkadi-Nagy, E.; Jaworski, K.; Ahmadian, M.; Sul, H.S.
J. Biol. Chem.
283
25428-25436
Expression and characterization of manganese lipoxygenase of the rice blast fungus reveals prominent sequential lipoxygenation of alpha-linolenic acid
2015
Wennman, A.; Jerneren, F.; Magnuson, A.; Oliw, E.H.
Arch. Biochem. Biophys.
583
87-95
Expression and characterization of manganese lipoxygenase of the rice blast fungus reveals prominent sequential lipoxygenation of alpha-linolenic acid
2015
Wennman, A.; Jerneren, F.; Magnuson, A.; Oliw, E.H.
Arch. Biochem. Biophys.
583
87-95
Links to other databases for 1,2-dilinoleoyl-sn-glycero-3-phosphocholine