Ligand trans-4-hydroxy-L-proline

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Basic Ligand Information

Molecular Structure
Picture of trans-4-hydroxy-L-proline (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H9NO3
trans-4-hydroxy-L-proline
PMMYEEVYMWASQN-DMTCNVIQSA-N
Synonyms:
(4R)-4-hydroxy-L-proline, (4R)-hydroxy-L-proline, trans-4-hydroxy-L-Pro, trans-4-hydroxyproline

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-proline + 2-oxoglutarate + O2 = trans-4-hydroxy-L-proline + succinate + CO2
show the reaction diagram
-
-
1-pyrroline-(4R)-hydroxy-2-carboxylate + NADPH + H+ = (4R)-hydroxy-L-proline + NADP+
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trans-4-hydroxy-L-proline + NADP+ = ? + NADPH + H+
show the reaction diagram
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trans-4-hydroxy-L-proline + oxidized dichlorophenolindophenol = ?
show the reaction diagram
trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H2O
show the reaction diagram
ATP + trans-4-hydroxyproline + tRNAPro = AMP + diphosphate + trans-4-hydroxyprolyl-tRNAPro
show the reaction diagram
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ATP + trans-4-hydroxy-L-proline + L-threonine = ADP + phosphate + trans-4-hydroxy-L-prolyl-L-threonine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-proline + 2-oxoglutarate + O2 = trans-4-hydroxy-L-proline + succinate + CO2
show the reaction diagram
-
-
1-pyrroline-(4R)-hydroxy-2-carboxylate + NADPH + H+ = (4R)-hydroxy-L-proline + NADP+
show the reaction diagram
-
-
cis-4-hydroxy-D-proline = trans-4-hydroxy-L-proline
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (267 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (13 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.19
-
at pH 7.5 and 25°C
45
-
pH not specified in the publication, temperature not specified in the publication
15
-
pH 7.0, 37°C, recombinant wild-type enzyme, amino acid activation

KM Value (19 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
200
-
at pH 7.5 and 25°C
1.2
-
pH not specified in the publication, temperature not specified in the publication
2
37
pH 7.0, 37°C, recombinant wild-type enzyme, amino acid activation

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for trans-4-hydroxy-L-proline

ChEBI
PubChem
ChEBI
PubChem