Ligand lacto-N-neotetraose

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Basic Ligand Information

Molecular Structure
Picture of lacto-N-neotetraose (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C26H45NO21
lacto-N-neotetraose
IEQCXFNWPAHHQR-OEMKBTDYSA-N
Synonyms:
D-Gal-beta-(1->4)-D-GlcNAc-beta-(1->3)-D-Gal-beta-(1->4)-D-Glc, Gal-beta-(1-4)-GlcNAc-beta-(1-3)-Gal-beta-(1-4)-Glc, Galbeta(1,4)GlcNAcbeta(1,3)Galbeta(1,4)Glc, Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc, Galbeta(1-4)GlcNAcbeta(1-3)Galbeta1-4Glc, Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP-fucose + Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc = Fucalpha1-2Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc + GDP
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Gal-beta-(1-4)-GlcNAc-[Fuc-alpha-(1-4)]-beta-(1-3)-Gal-beta-(1-4)-Glc + H2O = alpha-L-fucose + Gal-beta-(1-4)-GlcNAc-beta-(1-3)-Gal-beta-(1-4)-Glc
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-N-acetyl-D-glucosamine + Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc = UDP + GlcNAcbeta(1-3)Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc
show the reaction diagram
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UDP-N-acetyl-D-glucosamine + Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc = UDP + Galbeta(1-4)GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Galbeta(1-4)Glc
show the reaction diagram
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GDP-fucose + Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc = GDP + Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glc
show the reaction diagram
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Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc + H2O = ?
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3-O-fucosyllactose + lacto-N-neotetraose = lacto-N-fucopentaose III + lactose
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-Fuc-alpha-(1->3)-[D-Gal-beta-(1->4)]-D-GlcNAc-beta-(1->3)-D-Gal-beta-(1->4)-D-Glc + H2O = L-fucose + D-Gal-beta-(1->4)-D-GlcNAc-beta-(1->3)-D-Gal-beta-(1->4)-D-Glc
show the reaction diagram
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Gal-beta-(1-4)-GlcNAc-[Fuc-alpha-(1-4)]-beta-(1-3)-Gal-beta-(1-4)-Glc + H2O = alpha-L-fucose + Gal-beta-(1-4)-GlcNAc-beta-(1-3)-Gal-beta-(1-4)-Glc
show the reaction diagram
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Enzyme Kinetic Parameters

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.44
-
IGnT B
3.8
-
-
1.67
-
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References & Links

Links to other databases for lacto-N-neotetraose

ChEBI
PubChem
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PubChem