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Ligand Gly-Gly-Phe-Leu

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.14.4

Gly-Gly-Phe-Leu + H2O = ?

36179

-

3.4.22.40

Gly-Gly-Phe-Leu + H2O = ?

36712

-

3.4.24.77

Gly-Gly-Phe-Leu + H2O = Gly-Gly + Phe-Leu

667346

-

7.4.2.6

ATP + H2O + GGFL/out = ADP + phosphate + GGFL/in

713255

-

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.11.15

Tyr-Gly-Gly-Phe-Leu + H2O = Tyr + Gly-Gly-Phe-Leu

647039

-

3.4.11.2

Leu5-enkephalin + H2O = tyrosin + (2-5)Leu5-enkephalin

0, 35867

-

7.4.2.6

ATP + H2O + GGFL/out = ADP + phosphate + GGFL/in

0

-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

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Show Inhibitors (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.4.14.4

enkephalin fragment

683203

-

3.4.14.4

fragment of Leu-enkephalin

650445

-

3.4.14.4

2 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.4.14.4

50

-

-

36179

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.4.22.40

0.2

-

-

36712

K_i Value (3 results)

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Show KI Value (3 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.4.14.4

0.0235

-

-

683203

3.4.14.4

0.05

-

37°C, pH 7.4

650445

3.4.14.4

0.074

-

37°C, pH 7.4

650445

3.4.14.4

3 entries

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

35867

8963385

Purification and characterization of aminopeptidase M from muscle and mucosa of the pig intestine

1995

Terashima, H.; Bunnett, N.W.

J. Gastroenterol.

30

696-704

36179

3297170

Purification and characterization of enkephalinase B from rat brain membrane

1987

Inaoka, Y.; Tamaoki, H.

Biochim. Biophys. Acta

925

27-35

36712

9546047

Catalytic properties of the cysteine aminopeptidase PepC, a bacterial bleomycin hydrolase

1998

Mistou, M.Y.; Gripon, J.C.

Biochim. Biophys. Acta

1383

63-70

647039

8175799

Aminopeptidase Y, a new aminopeptidase from Saccharomyces cerevisiae. Purification, properties, localization, and processing by protease B

1994

Yasuhara, T.; Nakai, T.; Ohashi, A.

J. Biol. Chem.

269

13644-13650

650445

11209758

Human and rat dipeptidyl peptidase III: biochemical and mass spectrometric arguments for similarities and differences

2000

Abramic, M.; Schleuder, D.; Dolovcak, L.; Schroder, W.; Strupat, K.; Sagi, D.; Peter-Katalini, J.; Vitale, L.

Biol. Chem.

381

1233-1243

667346

16521041

Extracellular metalloendopeptidase of Streptomyces rimosus

2006

Vitale, L.; Vukelic, B.; Krizaj, I.

Arch. Microbiol.

185

183-191

683203

17338643

Human dipeptidyl peptidase III acts as a post-proline-cleaving enzyme on endomorphins

2007

Barsun, M.; Jajcanin, N.; Vukeli?, B.; Spoljari?, J.; Abrami?, M.

Biol. Chem.

388

343-348

713255

19808809

Arabidopsis OPT6 is an oligopeptide transporter with exceptionally broad substrate specificity

2009

Pike, S.; Patel, A.; Stacey, G.; Gassmann, W.

Plant Cell Physiol.

50

1923-1932

Links to other databases for Gly-Gly-Phe-Leu

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Show Links (1 entry)

ChEBI

PubChem

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