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Ligand butyrylthiocholine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.8

butyrylthiocholine + H2O = butyrate + thiocholine

693402, 691748, 692330, 695065, 691853

1p0p, 3D-view

3.1.1.8

butyrylthiocholine + H2O = thiocholine + butyrate

677953, 678430, 678453, 679287, 682920, 679471, 681113, 682854, 682916, 681741, 677385, 682120, 682017

1p0p, 3D-view

3.1.1.8

propionylthiocholine + H2O = thiocholine + propionate

682854

1p0p, 3D-view

3.1.1.8

3 entries

Substrate in Enzyme-catalyzed Reactions (20 results)

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Show Substrate (20 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.1

butyrylthiocholine + H2O = butyric acid + thiocholine

171000, 170991

-

3.1.1.7

butyrylthiocholine + H2O = butyrate + thiocholine

114196, 114188, 664581, 114177, 114132, 729761, 114176, 114131, 666286, 666537

2ha7, 3D-view

3.1.1.7

butyrylthiocholine + H2O = thiocholine + butanoate

666536, 663748

2ha7, 3D-view

3.1.1.7

butyrylthiocholine + H2O = thiocholine + butyrate

651163, 651202, 653108, 666232, 679339, 680690, 715174, 716986, 743326, 751802, 752305, 716835, 715182, 730711, 750356

2ha7, 3D-view

3.1.1.7

propionylthiocholine + H2O = propanoate + thiocholine

114188, 666232, 729761, 114176, 114131, 665263, 666537, 666633

2ha7, 3D-view

3.1.1.7

propionylthiocholine + H2O = thiocholine + propanoate

114182

2ha7, 3D-view

3.1.1.7

propionylthiocholine + H2O = thiocholine + propionate

651202, 653108, 752305, 651505, 716835, 663748, 715174, 749746, 743326, 751802, 650832, 715182, 750356

2ha7, 3D-view

3.1.1.7

S-butyrylthiocholine + H2O = thiocholine + butyrate

651505, 665263

2ha7, 3D-view

3.1.1.8

(S)-butyrylthiocholine + H2O = thiocholine + butyrate

751379

1p0p, 3D-view

3.1.1.8

butyrylthiocholine + H2O = ?

702676, 706041, 706828, 703783, 693392

1p0p, 3D-view

3.1.1.8

butyrylthiocholine + H2O = butanoate + thiocholine

94434, 663771, 94433, 94452, 94444, 94458, 94437, 664593, 94438, 94451, 94443, 94446, 94455, 94440

1p0p, 3D-view

3.1.1.8

butyrylthiocholine + H2O = butyrate + thiocholine

693402, 728949, 691748, 692330, 729273, 729566, 729571, 729569, 730567, 695065, 729092, 691853, 694563, 691739, 691749, 691103, 693553, 690496, 690624, 695287, 693570

1p0p, 3D-view

3.1.1.8

butyrylthiocholine + H2O = thiocholine + butyrate

650246, 714407, 649707, 650141, 650347, 650381, 650659, 650809, 651156, 651163, 651173, 652971, 653036, 653355, 666699, 667928, 677953, 678430, 678453, 678608, 679287, 682120, 682920, 750298, 679471, 714925, 651187, 681113, 714450, 714458, 751209, 649772, 750130, 653108, 682854, 751217, 666232, 679334, 682916, 650956, 750566, 714777, 649786, 681741, 679344, 652467, 653283, 677385, 714705, 749746, 749836, 749864, 750379, 751194, 751285, 752242, 750289, 750017, 750019, 750028, 750040, 750041, 750042, 750359, 750216, 679238, 653775, 682017, 714388, 714121, 714702, 750357, 750901, 751284

1p0p, 3D-view

3.1.1.8

bytyrylhiocholine + H2O = thiocholine + butyrate

649795

1p0p, 3D-view

3.1.1.8

propionylthiocholine + H2O = ?

703556, 694563

1p0p, 3D-view

3.1.1.8

propionylthiocholine + H2O = propanoate + thiocholine

94434, 94452, 94440, 94438, 666232, 94443, 35207, 94444

1p0p, 3D-view

3.1.1.8

propionylthiocholine + H2O = thiocholine + propanoate

665004

1p0p, 3D-view

3.1.1.8

propionylthiocholine + H2O = thiocholine + propionate

682854, 751217, 665855, 679334, 750566, 714777, 649786, 679344, 679238, 749746, 649795, 653775, 714388, 714121, 750357

1p0p, 3D-view

3.1.1.8

S-butyrylthiocholine + H2O = butyrate + thiocholine

729366

1p0p, 3D-view

3.1.1.7

7 entries

3.1.1.8

11 entries

3.4.19.1

butyryl thiocholine + H2O = ?

95264

-

Activator in Enzyme-catalyzed Reactions (2 results)

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Show Activating Compound (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.8

-

749746

1p0p, 3D-view

3.1.1.8

-

749746

1p0p, 3D-view

3.1.1.8

2 entries

Inhibitor in Enzyme-catalyzed Reactions (13 results)

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Show Inhibitors (13 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.7

-

694975, 749746

2ha7, 3D-view

3.1.1.7

N-methyl carbamate-resistant strain, no substrate inhibition up to 0.01 mM

666537

2ha7, 3D-view

3.1.1.7

-

749746

2ha7, 3D-view

3.1.1.7

N-methyl carbamate-resistant strain, no substrate inhibition up to 0.01 mM

666537

2ha7, 3D-view

3.1.1.7

substrate inhibition

682475

2ha7, 3D-view

3.1.1.7

the recombinant carp AChE shows substrate inhibition at high substrate concentrations of acetyl- and propionylthiocholine

694975

2ha7, 3D-view

3.1.1.8

competitive

665004

1p0p, 3D-view

3.1.1.8

competitive to butyrylcholine

667928

1p0p, 3D-view

3.1.1.8

slight substrate inhibition

749746

1p0p, 3D-view

3.1.1.8

substrate inhibition

714121

1p0p, 3D-view

3.1.1.8

substrate inhibition above 10 mM

666699

1p0p, 3D-view

3.1.1.8

slight substrate inhibition

749746

1p0p, 3D-view

3.1.1.8

substrate inhibition above 10 mM

666699

1p0p, 3D-view

3.1.1.7

6 entries

3.1.1.8

7 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (2 entries)

EC NUMBER

ENZYME 3D STRUCTURE

3.1.1.7

2ha7, 3D-view

3.1.1.8

1p0p, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (47 results)

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Show Turnover Number (47 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.1.1.7

3.72

-

recombinant enzyme, pH 8.0, 22°C

749746

3.1.1.7

111

-

25°C

665263

3.1.1.7

433

-

25°C

665263

3.1.1.8

0.016

-

pH 5, wild-type enzyme, absence of excess substrate

651156

3.1.1.8

0.05

-

pH 5, A328I mutant, presence of excess substrate

651156

3.1.1.8

0.4

-

pH 5, A328W and E197Q mutant, absence of excess substrate

651156

3.1.1.8

2

-

pH 5, L286W mutant, absence of excess substrate

651156

3.1.1.8

2

-

W82A mutant, pH 7, 25°C

650347

3.1.1.8

4.78

-

recombinant enzyme, pH 8.0, 22°C

749746

3.1.1.8

20.5

-

pH 5, A328I mutant, absence of excess substrate

651156

3.1.1.8

22.3

-

pH 5, A328G mutant, absence of excess substrate

651156

3.1.1.8

41.4

-

pH 5, Y332A mutant, presence of excess substrate

651156

3.1.1.8

46.67

-

mutant enzyme A199S/S287G/A328W/Y332G, at 25°C, in 0.1 M potassium phosphate, pH 7.5

714702

3.1.1.8

46.7

-

pH 5, wild-type enzyme, absence of excess substrate

651156

3.1.1.8

48.3

-

pH 5, Y332A mutant, absence of excess substrate

651156

3.1.1.8

49.2

-

pH 7.4, 37°C

653775

3.1.1.8

50

-

recombinant enzyme, pH 8.0, 22°C

749746

3.1.1.8

53.3

-

pH 5, A328W and E197Q mutant, absence of excess substrate

651156

3.1.1.8

53.3

-

recombinant enzyme, pH 8.0, 22°C

749746

3.1.1.8

67

-

E197D mutant, pH 7, 25°C

650347

3.1.1.8

71.7

-

pH 5, L286W mutant, absence of excess substrate

651156

3.1.1.8

83

-

W430A mutant, pH 7, 25°C

650347

3.1.1.8

98

-

pH 7.0, 25°C, mutant G333C

694563

3.1.1.8

105

-

pH 5, V288W mutant, absence of excess substrate

651156

3.1.1.8

110

-

pH 5, A328F mutant, absence of excess substrate

651156

3.1.1.8

150

-

E197Q mutant, pH 7, 25°C

650347

3.1.1.8

250

-

K339M mutant, pH 7, 25°C

650347

3.1.1.8

290

-

pH 5, L286W mutant, presence of excess substrate

651156

3.1.1.8

333

-

G328G mutant, pH 7, 25°C

650347

3.1.1.8

338

-

pH 7.0, 25°C, mutant V294M

694563

3.1.1.8

450

-

wild-type, pH 7, 25°C

650347

3.1.1.8

490

-

pH 7.0, 25°C, mutant R470W

694563

3.1.1.8

491.7

-

wild type enzyme, at 25°C, in 0.1 M potassium phosphate, pH 7.5

714702

3.1.1.8

500

-

pH 7.0, 25°C, wild-type enzyme

694563

3.1.1.8

508

-

E497V/A539T mutant, pH 7, 25°C

652971

3.1.1.8

533

-

A328F mutant, pH 7, 25°C

650347

3.1.1.8

542

-

A539T mutant and E497V mutant, pH 7, 25°C

652971

3.1.1.8

565

-

wild-type, pH 7, 25°C

652971

3.1.1.8

585

-

pH 7.0, 25°C, mutant K12R

694563

3.1.1.8

617

-

N83A mutant, pH 7, 25°C

650347

3.1.1.8

667

-

A328Y mutant, pH 7, 25°C

650347

3.1.1.8

767

-

N83Q mutant, pH 7, 25°C

650347

3.1.1.8

920

-

pH 5, A328F mutant, presence of excess substrate

651156

3.1.1.8

1048

-

pH 5, V288W mutant, presence of excess substrate

651156

3.1.1.8

1050

-

pH 5, V288W mutant, presence of excess substrate

651156

3.1.1.8

2066.7

-

pH 7.4, 25°C, recombinant enzyme

750130

3.1.1.8

3350

-

pH 7.0, 25°C

649795

3.1.1.7

3 entries

3.1.1.8

44 entries

K_M Value (136 results)

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Show KM Value (136 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.1.7

0.00289

-

pH 7.2, 25°C

752305

3.1.1.7

0.012

-

pH 7.5, 24°C, Huanghua population

666536

3.1.1.7

0.0139

-

recombinant enzyme, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4

715182

3.1.1.7

0.0158

-

isoform AChE2, in 10 mM Na2HPO4/NaH2PO4, pH 7.4, pH, at 22°C

715174

3.1.1.7

0.016

-

pH 7.3, 37°C, recombinant enzyme

751802

3.1.1.7

0.0213

-

native enzyme from head extract, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4

715182

3.1.1.7

0.0244

-

isoform AChE2, in 10 mM Na2HPO4/NaH2PO4, pH 7.4, pH, at 22°C

715174

3.1.1.7

0.026

-

pH 7.5, 24°C, Pingshan population

666536

3.1.1.7

0.027

-

25°C

665263

3.1.1.7

0.031

-

-

651505

3.1.1.7

0.0334

-

-

651505

3.1.1.7

0.036

-

-

679339

3.1.1.7

0.03607

-

pH 7.2, 25°C

752305

3.1.1.7

0.0376

-

isoform AChE1, in 10 mM Na2HPO4/NaH2PO4, pH 7.4, pH, at 22°C

715174

3.1.1.7

0.0391

-

pH 7.5, 25°C, N-methyl carbamate-susceptible strain

666537

3.1.1.7

0.0461

-

pH 7.5, 25°C, N-methyl carbamate-susceptible strain

666537

3.1.1.7

0.056

-

pH 7.3, 37°C, recombinant enzyme

751802

3.1.1.7

0.0568

-

native enzyme from head extract, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4

715182

3.1.1.7

0.062

-

pH 7.3, 37°C, recombinant enzyme

751802

3.1.1.7

0.0684

-

isoform AChE1, in 10 mM Na2HPO4/NaH2PO4, pH 7.4, pH, at 22°C

715174

3.1.1.7

0.072

-

recombinant enzyme, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4

715182

3.1.1.7

0.0852

-

pH 7.5, 25°C, N-methyl carbamate-resisitant strain

666537

3.1.1.7

0.0881

-

pH 7.5, 25°C, N-methyl carbamate-resistant strain

666537

3.1.1.7

0.093

-

pH 7.0, 22°C, recombinant wild-type enzyme

680690

3.1.1.7

0.0967

-

in potassium phosphate buffer (100 mM, pH 7.5), at 25°C

716986

3.1.1.7

0.11

-

form II

114176

3.1.1.7

0.137

-

-

114188

3.1.1.7

0.148

-

gamma form

114182

3.1.1.7

0.15

-

recombinant enzyme, pH 8.0, 22°C

749746

3.1.1.7

0.156

-

recombinant enzyme, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4

715182

3.1.1.7

0.1785

-

recombinant enzyme, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4

715182

3.1.1.7

0.179

-

isoform AChE2, at 30°C, pH not specified in the publication

730711

3.1.1.7

0.195

-

25°C

665263

3.1.1.7

0.1986

-

pH 8.0, temperature not specified in the publication

743326

3.1.1.7

0.206

-

pH 7.3, 37°C, recombinant enzyme

751802

3.1.1.7

0.2694

-

pH 7.5, temperature not specified in the publication

743326

3.1.1.7

0.2793

-

pH 7.5, temperature not specified in the publication

743326

3.1.1.7

0.374

-

-

666286

3.1.1.7

0.395

-

-

666286

3.1.1.7

0.398

-

form I

114176

3.1.1.7

0.399

-

-

666286

3.1.1.7

0.5036

-

pH 8.0, temperature not specified in the publication

743326

3.1.1.7

0.63

-

in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication

729761

3.1.1.7

0.8588

-

pH 7.0, temperature not specified in the publication

743326

3.1.1.7

1.02

-

in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication

729761

3.1.1.7

1.1486

-

pH 7.0, temperature not specified in the publication

743326

3.1.1.7

1.2

-

pH 8.5, 35°C, isozyme AChEB

750356

3.1.1.7

1.418

-

pH 7.2, 25°C

752305

3.1.1.7

1.529

-

pH 7.0, temperature not specified in the publication

743326

3.1.1.7

1.548

-

pH 7.0, temperature not specified in the publication

743326

3.1.1.7

1.61

-

in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication

729761

3.1.1.7

1.78

-

-

114188

3.1.1.7

1.8

-

pH 8.5, 35°C, isozyme AChEB

750356

3.1.1.7

1.8

-

pH 8.5, 35°C, isozyme AChEA

750356

3.1.1.7

2.23

-

isoform AChE1, at 30°C, pH not specified in the publication

730711

3.1.1.7

2.24

-

in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication

729761

3.1.1.7

2.8

-

pH 8.5, 35°C, isozyme AChEA

750356

3.1.1.7

2.9

-

in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication

729761

3.1.1.7

3.1

-

pH 7.0, 30°C

666633

3.1.1.7

3.717

-

pH 7.2, 25°C

752305

3.1.1.7

4.23

-

in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication

729761

3.1.1.7

4.496

-

pH 7.0, temperature not specified in the publication

743326

3.1.1.7

4.542

-

pH 7.0, temperature not specified in the publication

743326

3.1.1.7

4.7

-

-

664581

3.1.1.7

5.14

-

in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication

729761

3.1.1.7

27.912

-

pH 7.2, 25°C

752305

3.1.1.8

0.000106

-

pH 7.4, 37°C

649786

3.1.1.8

0.0041

-

pH 7.5, 25°C

665855

3.1.1.8

0.0052

-

pH 7.5, 25°C

665855

3.1.1.8

0.0083

-

mutant enzyme A199S/S287G/A328W/Y332G, at 25°C, in 0.1 M potassium phosphate, pH 7.5

714702

3.1.1.8

0.011

-

A328Y mutant, pH 7, 25°C

650347

3.1.1.8

0.0118

-

pH 7.0, 25°C, mutant V294M

694563

3.1.1.8

0.015

-

recombinant enzyme, pH 8.0, 22°C

749746

3.1.1.8

0.0169

-

pH 7.0, 25°C, mutant R470W

694563

3.1.1.8

0.017

-

A328F mutant, pH 7, 25°C

650347

3.1.1.8

0.017

-

A539T mutant, E497V/A539T mutant and E497V mutant, pH 7, 25°C

652971

3.1.1.8

0.017

-

recombinant enzyme, pH 8.0, 22°C

749746

3.1.1.8

0.0177

-

serum enzyme, pH 8, 25°C

650659

3.1.1.8

0.018

-

pH 7.4, 30°C

666699

3.1.1.8

0.02

-

wild-type, pH 7, 25°C

650347

3.1.1.8

0.021

-

pH 7, 22°C, native and intermediate state of the enzyme

649707

3.1.1.8

0.021

-

wild type enzyme, at 25°C, in 0.1 M potassium phosphate, pH 7.5

714702

3.1.1.8

0.023

-

wild-type, pH 7, 25°C

652971

3.1.1.8

0.025

-

recombinant enzyme, pH 8, 25°C

650659

3.1.1.8

0.0273

-

pH 7.0, 25°C, wild-type enzyme

694563

3.1.1.8

0.028

-

G328G mutant, pH 7, 25°C

650347

3.1.1.8

0.0316

-

pH 7.0, 25°C, mutant K12R

694563

3.1.1.8

0.0357

-

pH 7.0, 25°C, mutant G333C

694563

3.1.1.8

0.05

-

N83A mutant, pH 7, 25°C

650347

3.1.1.8

0.053

-

pH 7.5, 25°C

665855

3.1.1.8

0.06

-

N83Q and K339M mutant, pH 7, 25°C

650347

3.1.1.8

0.0689

-

pH 7.6, mean value of different animal muscle samples, overview

681741

3.1.1.8

0.094

-

pH 7.0, 25°C, R286L mutant

649795

3.1.1.8

0.1

-

E197D and E197Q mutant, pH 7, 25°C

650347

3.1.1.8

0.1

-

incubation of butyrylthiocholine in a concentration range of 0.005-3.0 mM, with 317 pM human butyrylcholinesterase in vitro, Michaelis-Menten kinetics

706828

3.1.1.8

0.112

-

pH 7.4, 25°C, recombinant enzyme

750130

3.1.1.8

0.112

-

pH 7.0, 25°C, R286L mutant

649795

3.1.1.8

0.115

-

pH 7.4, 37°C

653775

3.1.1.8

0.1237

-

pH 8.0, 25°C

750357

3.1.1.8

0.134

-

pH 7.0, 25°C, wild-type

649795

3.1.1.8

0.15

-

pH 7.5, 25°C

665855

3.1.1.8

0.16

-

pH 7.4, 25°C, enzyme from muscle

750566

3.1.1.8

0.16

-

pH 7.5, 37°C

751209

3.1.1.8

0.163

-

pH 7.4, 25°C, enzyme from yolk-sac of seabream larvae stage

750566

3.1.1.8

0.18

-

pH 7.5, 25°C

665855

3.1.1.8

0.189

-

pH 7.0, 25°C, wild-type

649795

3.1.1.8

0.19

-

pH 7.5, 25°C

665855

3.1.1.8

0.19

-

in 0.1 M phosphate buffer, pH 7.5, at 30°C

714121

3.1.1.8

0.19

-

pH 7.5, 25°C

665855

3.1.1.8

0.2

-

E197G mutant, pH 7, 25°C

650347

3.1.1.8

0.2

-

in 0.1 M phosphate buffer, pH 7.5, at 30°C

714121

3.1.1.8

0.2

-

mBuChE II

94444

3.1.1.8

0.2

-

pH 7.5, 25°C

665855

3.1.1.8

0.23

-

recombinant enzyme, pH 8.0, 22°C

749746

3.1.1.8

0.25

-

recombinant enzyme, pH 8.0, 22°C

749746

3.1.1.8

0.26

-

-

665004

3.1.1.8

0.32

-

pH 7.8

679238

3.1.1.8

0.33

-

immobilized enzyme

94446

3.1.1.8

0.39

-

pH 7.5, 25°C

665855

3.1.1.8

0.4

-

W82A mutant, pH 7, 25°C

650347

3.1.1.8

0.5

-

mBuChE II

94444

3.1.1.8

0.55

-

enzyme from muscle, pH 7.4, temperature not specified in the publication

750216

3.1.1.8

0.57

-

atypical variant

35207

3.1.1.8

0.58

-

pH 7.5, 25°C

665855

3.1.1.8

0.6254

-

pH 8.0, 25°C

750357

3.1.1.8

0.7

-

fluoride resistant variant

35207

3.1.1.8

0.76

-

usual variant

35207

3.1.1.8

1.24

-

enzyme from head, pH 7.4, temperature not specified in the publication

750216

3.1.1.8

1.4

-

pH 7.5, 25°C

665855

3.1.1.8

1.5

-

pH 7.5, 25°C

665855

3.1.1.8

1.7

-

mBuChE I

94444

3.1.1.8

1.87

-

soluble enzyme

94446

3.1.1.8

3.19

-

pH 7.8

679238

3.1.1.8

5.4

-

mBuChE II

94444

3.1.1.8

6

-

W430A mutant, pH 7, 25°C

650347

3.1.1.7

66 entries

3.1.1.8

69 entries

3.4.19.1

1

-

-

95264

K_i Value (1 result)

top print hide

Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.1.8

0.05

-

-

665004

References & Links

Literature References (155)

top print hide

Show Reference (155 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

35207

8597092

Catalytic properties and distribution profiles of paraoxonase and cholinesterase phenotypes in human sera

1995

Reiner, E.; Simeon-Rudolf, V.; Skrinjaric-Spoljar, M.

Toxicol. Lett.

82/83

447-452

94433

4336418

Cholinesterase activities in subcellular fractions of rat liver. Association of acetylcholinesterase with the surface membrane and other properties of the enzyme

1972

Wheeler, G.E.; Coleman, R.; Finean, J.B.

Biochim. Biophys. Acta

255

917-930

94434

16658363

Cholinesterases from plant tissues

1973

Riov, J.; Jaffe, M.J.

Plant Physiol.

51

520-528

94437

4462752

The purification of cholinesterase from horse serum

1974

Main, A.R.; Soucie, W.G.; Buxton, I.L.; Arinc, E.

Biochem. J.

143

733-744

94438

67

Cholinesterase from plant tissues. VI. Preliminary characterization of the enzyme from Solanum melongena L. and Zea mays L.

1975

Fluck, R.A.; Jaffe, M.J.

Biochim. Biophys. Acta

410

130-134

94440

5141

Purification and characterization of butyrylcholine-hydrolyzing enzyme from Pseudomonas polycolor

1976

Nagasawa, T.; Sugisaki, H.; Tani, Y.; Ogata, K.

Biochim. Biophys. Acta

429

817-827

94443

7407196

Hen's egg yolk cholinesterase

1980

Saeed, A.; De Boeck, St.; Debruyne, I.; Wouters, J.; Stockx, J.

Biochim. Biophys. Acta

614

389-399

94444

7391074

Resolution and purification of two monomeric butyrylcholinesterases from rabbit liver

1980

Rush, R.S.; Main, A.R.; Miller, S.K.; Kilpatrick, B.F.

J. Biol. Chem.

255

7155-7160

94446

-

Preparation and properties of a novel immobilized cholinesterase

1982

Kovacs, K.; Szajani, B.; Boross, L.

J. Appl. Biochem.

4

11-18

94451

1360365

Characterization of cholinesterases from the parasitic nematode Trichinella spiralis

1992

DeVos, T.; Dick, T.A.

Comp. Biochem. Physiol. C

103

129-134

94452

1540236

Cholinesterases of heart muscle

1992

Chemnitius, J.M.; Chemnitius, G.C.; Haselmeyer, K.H.; Kreuzer, H.; Zech, R.

Biochem. Pharmacol.

43

823-829

94455

8461052

Purification and immunological characterization of pigeon serum butyrylcholinesterase

1993

Khattab, A.D.; Walker, C.H.; Mackness M.I.; Saphir, P.W.

Biochem. Pharmacol.

45

991-998

94458

8343984

Sheep brain pseudocholinesterase: inhibition kinetics of the partially purified enzyme by some substrate analogues

1993

Cokugras, A.N.; Tezcan, F.

Chem. Biol. Interact.

87

259-264

95264

8195144

Human acylpeptide hydrolase. Studies on its thiol groups and mechanism of action

1994

Scaloni, A.; Barra, D.; Jones, W.M.; Manning, J.M.

J. Biol. Chem.

269

15076-15084

114131

9669090

Characterization of acetylcholinesterase purified from the lesser grain borer, Rhyzopertha dominica (Coleoptera: Bostrichidae)

1998

Guedes, R.N.C.; Zhu, K.Y.; Kambhampati, S.; Cover, B.A.

Comp. Biochem. Physiol. B

119

205-210

114132

8896335

Biochemical and molecular characterization of acetylcholinesterase from the hagfish Myxine glutinosa

1996

Sanders, M.; Mathews, B.; Sutherland, D.; Soong, W.; Giles, H.; Pezzementi, L.

Comp. Biochem. Physiol. B

115

97-109

114176

9761457

Acetylcholinesterase at high catalytic efficiency and substrate specificity in the optic lobe of Eledone moschata (Cephalopoda: Octopoda): biochemical characterization and histochemical localization

1998

Talesa, V.; Romani, R.; Calvitti, M.; Rosi, G.; Giovannini, E.

Neurochem. Int.

33

131-141

114177

10092608

Cloning, expression, and properties of a nonneuronal secreted acetylcholinesterase from the parasitic nematode Nippostrongylus brasiliensis

1999

Hussein, A.S.; Chacon, M.R.; Smith, A.M.; Tosado-Acevedo, R.; Selkirk, M.E.

J. Biol. Chem.

274

9312-9319

114182

8681969

Acetylcholinesterase in Dendrobaena veneta (Oligochaeta: Opisthopora) is present with forms sensitive and insensitive to phosphatidylinositol phospholipase C. Biochemical characterization and histochemical localization in the nervous system

1996

Talesa, V.; Romani, R.; Rosi, G.; Giovanni, E.

Eur. J. Biochem.

238

538-548

114188

1979353

Properties of acetylcholinesterase in axolemma-enriched fractions isolated from bovine splenic nerve

1990

Hannesson, H.H.; DeVries, G.H.

J. Neurosci. Res.

27

84-88

114196

1541336

Characterization of acetylcholinesterase and butyrylcholinesterase activities in retinal chick pigment epithelium during development

1992

Salceda, R.; Martinez, M.T.

Exp. Eye Res.

54

17-22

170991

6417119

Human liver carboxylesterase. Properties and comparison with human serum carboxylesterase

1983

Tsujita, T.; Okuda, H.

J. Biochem.

94

793-797

171000

446478

Characterization of the isoenzymes of pig-liver esterase. 2. Kinetic studies

1979

Junge, W.; Heymann, E.

Eur. J. Biochem.

95

519-525

649707

11368776

Pressure- and heat-induced inactivation of butyrylcholinesterase: evidence for multiple intermediates and the remnant inactivation process

2001

Weingand-Ziade, A.; Ribes, F.; Renault, F.; Masson, P.

Biochem. J.

356

487-493

649772

14575524

Amino acid domains control the circulatory residence time of primate acetylcholinesterases in rhesus macaques (Macaca mulatta)

2004

Cohen, O.; Kronman, C.; Velan, B.; Shafferman, A.

Biochem. J.

378

117-128

649786

10718335

Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation

2000

Wierdl, M.; Morton, C.L.; Danks, M.K.; Potter, P.M.

Biochem. Pharmacol.

59

773-781

649795

12110369

DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase

2002

Boeck, A.T.; Schopfer, L.M.; Lockridge, O.

Biochem. Pharmacol.

63

2101-2110

650141

11888271

Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug Rivastigmine

2002

Bar-On, P.; Millard, C.B.; Harel, M.; Dvir, H.; Enz, A.; Sussman, J.L.; Silman, I.

Biochemistry

41

3555-3564

650246

15023072

Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates

2004

Kovarik, Z.; Radic, Z.; Berman, H.A.; Simeon-Rudolf, V.; Reiner, E.; Taylor, P.

Biochemistry

43

3222-3229

650347

11341926

Effects of mutations of active site residues and amino acids interacting with the W loop on substrate activation of butyrylcholinesterase

2001

Masson, P.; Xie, W.; Froment, M.T.; Lockridge, O.

Biochim. Biophys. Acta

1544

166-176

650381

12044901

Butyrylcholinesterase-catalyzed hydrolysis of N-methylindoxyl acetate: analysis of volume changes upon reaction and hysteretic behavior

2002

Masson, P.; Froment, M.T.; Fort, S.; Ribes, F.; Bec, N.; Balny, C.; Schopfer, L.M.

Biochim. Biophys. Acta

1597

229-243

650659

-

Expression of biologically active human butyrylcholinesterase in the cabbage looper (Trichoplusia ni)

2000

Platteborze, P.L.; Broomfield, C.A.

Biotechnol. Appl. Biochem.

31

225-229

650809

11569538

Butyrylcholinesterase-mediated enhancement of the enzymatic activity of trypsin

2001

Darvesh, S.; Kumar, R.; Roberts, S.; Walsh, R.; Martin, E.

Cell. Mol. Neurobiol.

21

285-296

650832

11311211

Soluble and membrane-bound acetylcholinesterases in Mytilus galloprovincialis (Pelecypoda: Filibranchia) from the northern Adriatic sea

2001

Talesa, V.; Romani, R.; Antognelli, C.; Giovannini, E.; Rosi, G.

Chem. Biol. Interact.

134

151-166

650956

12019201

Characterization of equine butyrylcholinesterase disposition in the mouse

2002

Koetzner, L.; Woods, J.H.

Drug Metab. Dispos.

30

724-730

651156

12605682

High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine

2003

Masson, P.; Nachon, F.; Bartels, C.F.; Froment, M.T.; Ribes, F.; Matthews, C.; Lockridge, O.

Eur. J. Biochem.

270

315-324

651163

14622273

Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases

2003

Saxena, A.; Fedorko, J.M.; Vinayaka, C.R.; Medhekar, R.; Radic, Z.; Taylor, P.; Lockridge, O.; Doctor, B.P.

Eur. J. Biochem.

270

4447-4458

651173

14686935

Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate

2004

Masson, P.; Goldstein, B.N.; Debouzy, J.C.; Froment, M.T.; Lockridge, O.; Schopfer, L.M.

Eur. J. Biochem.

271

220-234

651187

-

Stereoselective hydrolysis of quaternary quinuclidinium benzoates catalyzed by butyrylcholinesterase

2003

Primozic, I.; Hrenar, T.; Tomic, S.; Meic, Z.

Eur. J. Org. Chem.

2003

295-301

651202

12094012

Characterization of acetylcholinesterase in Caco-2 cells

2002

Plageman, L.R.; Pauletti, G.M.; Skau, K.A.

Exp. Biol. Med.

227

480-486

651505

11520688

An acetylcholinesterase purified from the greenbug (Schizaphis graminum) with some unique enzymological and pharmacological characteristics

2001

Gao, J.R.; Zhu, K.Y.

Insect Biochem. Mol. Biol.

31

1095-1104

652467

12869558

Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products

2003

Nicolet, Y.; Lockridge, O.; Masson, P.; Fontecilla-Camps, J.C.; Nachon, F.

J. Biol. Chem.

278

41141-41147

652971

10646540

The butyrylcholinesterase K-variant shows similar cellular protein turnover and quaternary interaction to the wild-type enzyme

2000

Altamirano, C.V.; Bartels, C.F.; Lockridge, O.

J. Neurochem.

74

869-877

653036

12018615

A new perspective on thermal inactivation kinetics of human serum butyrylcholinesterase

2002

Cengiz, D.; Cokugras, A.N.; Tezcan, E.F.

J. Protein Chem.

21

145-149

653108

14580806

Characterization of choline esterases and their tissue and subcellular distribution in mussel (Mytilus edulis)

2003

Brown, M.; Davies, I.M.; Moffat, C.F.; Redshaw, J.; Craft, J.A.

Mar. Environ. Res.

57

155-169

653283

12130672

Re-engineering butyrylcholinesterase as a cocaine hydrolase

2002

Sun, H.; Pang, Y.P.; Lockridge, O.; Brimijoin, S.

Mol. Pharmacol.

62

220-224

653355

12675140

Cholinesterases: New roles in brain function and in Alzheimer's disease

2003

Giacobini, E.

Neurochem. Res.

28

515-522

653775

15106880

Partial purification and characterization of soluble isoform of butyrylcholinesterase from rat intestine

2004

Yildiz, O.; Bodur, E.; Cokugras, A.N.; Ozer, N.

Protein J.

23

143-151

663748

16497396

Cholinesterase from the common prawn (Palaemon serratus) eyes: Catalytic properties and sensitivity to organophosphate and carbamate compounds

2006

Frasco, M.F.; Fournier, D.; Carvalho, F.; Guilhermino, L.

Aquat. Toxicol.

77

412-421

663771

16036213

Inhibition of human plasma cholinesterase by malachite green and related triarylmethane dyes: mechanistic implications

2005

Kucukkilinc, T.; Ozer, I.

Arch. Biochem. Biophys.

440

118-122

664581

16429548

Characterizing pea acetylcholinesterase

2005

Muralidharan, M.; Soreq, H.; Mor, T.S.

Chem. Biol. Interact.

157-158

406-407

664593

16022504

Ortho effects for inhibition mechanisms of butyrylcholinesterase by o-substituted phenyl N-butyl carbamates and comparison with acetylcholinesterase, cholesterol esterase, and lipase

2005

Lin, G.; Lee, Y.R.; Liu, Y.C.; Wu, Y.G.

Chem. Res. Toxicol.

18

1124-1131

665004

1657699

Pseudomonas aeruginosa cholinesterase and phosphorylcholine phosphatase: two enzymes contributing to corneal infection

1991

Domenech, C.E.; Garrido, M.N.; Lisa, T.A.

FEMS Microbiol. Lett.

66

131-135

665263

15315367

Purification and characterization of acetylcholinesterase from oriental fruit fly (Bactrocera dorsalis (Hendel)) (Diptera: Tephritidae)

2004

Hsiao, Y.M.; Lai, J.Y.; Liao, H.Y.; Feng, H.T.

J. Agric. Food Chem.

52

5340-5346

665855

-

Comparative study of substrate-inhibitor specificity of brain cholinesterase activity of pacific salmon fish of the Salmonidae family

2004

Kovalev, N.N.; Rozengart, E.V.; Chepkasova, A.I.

J. Evol. Biochem. Physiol.

40

258-263

666232

15178074

Characterization of cholinesterase activity from different tissues of Nile tilapia (Oreochromis niloticus)

2004

Rodriguez-Fuentes, G.; Gold-Bouchot, G.

Mar. Environ. Res.

58

505-509

666286

15811534

Expression and comparative functional characterization of recombinant acetylcholinesterase from three species of Schistosoma

2005

Bentley, G.N.; Jones, A.K.; Agnew, A.

Mol. Biochem. Parasitol.

141

119-123

666536

-

Comparative studies of acetylcholinesterases purified from two field populations of the oriental migratory locust (Locusta migratoria manilensis): implications of insecticide resistance

2004

Ma, E.B.; He, Y.P.; Zhu, K.Y.

Pestic. Biochem. Physiol.

78

67-77

666537

-

Comparison of kinetic properties of a hydrophilic form of acetylcholinesterase purified from strains susceptible and resistant to carbamate and organophosphorus insecticides of green rice leafhopper (Nephotettix cincticeps Uhler)

2004

Kato, Y.; Tanaka, T.; Miyata, T.

Pestic. Biochem. Physiol.

79

64-73

666633

15980188

Molecular characterization of maize acetylcholinesterase: a novel enzyme family in the plant kingdom

2005

Sagane, Y.; Nakagawa, T.; Yamamoto, K.; Michikawa, S.; Oguri, S.; Momonoki, Y.S.

Plant Physiol.

138

1359-1371

666699

-

Simplified procedures for purification and stabilization of human plasma butyrylcholinesterase

2004

Mehrani, H.

Proc. Biochem.

39

877-882

667928

16504521

On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases

2006

Darvesh, S.; McDonald, R.S.; Darvesh, K.V.; Mataija, D.; Mothana, S.; Cook, H.; Carneiro, K.M.; Richard, N.; Walsh, R.; Martin, E.

Bioorg. Med. Chem.

14

4586-4599

677385

17768338

Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase

2007

Ngamelue, M.N.; Homma, K.; Lockridge, O.; Asojo, O.A.

Acta Crystallogr. Sect. F

63

723-727

677953

17335779

Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates

2007

Schallreuter, K.U.; Gibbons, N.C.; Elwary, S.M.; Parkin, S.M.; Wood, J.M.

Biochem. Biophys. Res. Commun.

355

1069-1074

678430

17307293

A versatile equation to describe reversible enzyme inhibition and activation kinetics: modeling beta-galactosidase and butyrylcholinesterase

2007

Walsh, R.; Martin, E.; Darvesh, S.

Biochim. Biophys. Acta

1770

733-746

678453

17690023

Kinetic analysis of butyrylcholinesterase-catalyzed hydrolysis of acetanilides

2007

Masson, P.; Froment, M.; Gillon, E.; Nachon, F.; Darvesh, S.; Schopfer, L.M.

Biochim. Biophys. Acta

1774

1139-1147

678608

17008100

Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones

2007

Piazzi, L.; Belluti, F.; Bisi, A.; Gobbi, S.; Rizzo, S.; Bartolini, M.; Andrisano, V.; Recanatini, M.; Rampa, A.

Bioorg. Med. Chem.

15

575-585

679238

17998142

Cholinesterase activities as potential biomarkers: Characterization in two freshwater snails, Potamopyrgus antipodarum (Mollusca, Hydrobiidae, Smith 1889) and Valvata piscinalis (Mollusca, Valvatidae, Mueller 1774)

2008

Gagnaire, B.; Geffard, O.; Xuereb, B.; Margoum, C.; Garric, J.

Chemosphere

71

553-560

679287

17379201

Human serum cholinesterase from liver pathological samples exhibit highly elevated aryl acylamidase activity

2007

Boopathy, R.; Rajesh, R.V.; Darvesh, S.; Layer, P.G.

Clin. Chim. Acta

380

151-156

679334

-

Tissue distribution and characterization of cholinesterase activity in six earthworm species

2007

Rault, M.; Mazzia, C.; Capowiez, Y.

Comp. Biochem. Physiol. B

147B

340-346

679339

18166494

Acetylcholinesterase in the sea urchin Lytechinus variegatus: Characterization and developmental expression in larvae

2008

Jennings, N.A.; Pezzementi, L.; Lawrence, A.L.; Watts, S.A.

Comp. Biochem. Physiol. B

149

401-409

679344

16753348

In vitro characterization of cholinesterases in the earthworm Eisenia andrei

2006

Caselli, F.; Gastaldi, L.; Gambi, N.; Fabbri, E.

Comp. Biochem. Physiol. C

143

416-421

679471

17934924

Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase

2007

Bajgar, J.; Bartosova, L.; Kuca, K.; Jun, D.; Fusek, J.

Drug Chem. Toxicol.

30

351-359

680690

16837465

Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding

2006

Bourne, Y.; Radic, Z.; Sulzenbacher, G.; Kim, E.; Taylor, P.; Marchot, P.

J. Biol. Chem.

281

29256-29267

681113

-

How thionphosphonates inhibit activity of different cholinesterases

2007

Rozengart, E.V.; Basova, N.E.; Suvorov, A.A.

J. Evol. Biochem. Physiol.

43

164-173

681741

17300836

Characterization of cholinesterases in marbled sole, Limanda yokohamae, and their inhibition in vitro by the fungicide iprobenfos

2007

Jung, J.H.; Addison, R.F.; Shim, W.J.

Mar. Environ. Res.

63

471-478

682017

17347320

The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates

2007

Groner, E.; Ashani, Y.; Schorer-Apelbaum, D.; Sterling, J.; Herzig, Y.; Weinstock, M.

Mol. Pharmacol.

71

1610-1617

682120

17985237

Kinetics of human serum butyrylcholinesterase inhibition by a novel experimental alzheimer therapeutic, dihydrobenzodioxepine cymserine

2007

Kamal, M.A.; Klein, P.; Luo, W.; Li, Y.; Holloway, H.W.; Tweedie, D.; Greig, N.H.

Neurochem. Res.

33

745-753

682475

18046576

Characterization of trimeric acetylcholinesterase from a legume plant, Macroptilium atropurpureum Urb.

2008

Yamamoto, K.; Oguri, S.; Momonoki, Y.S.

Planta

227

809-822

682854

18177688

Cholinesterase activities in the scallop Pecten jacobaeus: characterization and effects of exposure to aquatic contaminants

2008

Stefano, B.; Ilaria, C.; Silvano, F.

Sci. Total Environ.

392

99-109

682916

16597480

Inhibition of cholinesterase activity by azinphos-methyl in two freshwater invertebrates: Biomphalaria glabrata and Lumbriculus variegatus

2006

Kristoff, G.; Guerrero, N.V.; de DAngelo, A.M.; Cochon, A.C.

Toxicology

222

185-194

682920

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Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase

2007

Bartling, A.; Worek, F.; Szinicz, L.; Thiermann, H.

Toxicology

233

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Activation mechanisms of butyrylcholinesterase by 2,4,6-trinitrotoluene, 3,3-dimethylbutyl-N-n-butylcarbamate, and 2-trimethylsilyl-ethyl-N-n-butylcarbamate

2008

Chiou, S.Y.; Wu, Y.G.; Lin, G.

Appl. Biochem. Biotechnol.

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Comparative effects of cationic triarylmethane, phenoxazine and phenothiazine dyes on horse serum butyrylcholinesterase

2008

Yuecel, Y.Y.; Tacal, O.; Ozer, I.

Arch. Biochem. Biophys.

478

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Kinetic study of the thermal inactivation of cholinesterase enzymes immobilized in solid matrices

2008

Bromberg, A.; Marx, S.; Frishman, G.

Biochim. Biophys. Acta

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Characterisation of cholinesterase expression during murine embryonic stem cell differentiation

2008

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Chem. Biol. Interact.

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An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties

2008

Gao, Y.; LaFleur, D.; Shah, R.; Zhao, Q.; Singh, M.; Brimijoin, S.

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2008

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Butyrylcholinesterase activity and mortality risk in hemodialysis patients: comparison to hsCRP and albumin

2009

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Clin. Biochem.

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Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase

2009

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FEBS J.

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Butyrylcholinesterase, lipoxygenase inhibiting and antifungal alkaloids from Isatis tinctoria

2008

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J. Enzyme Inhib. Med. Chem.

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2008

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J. Evol. Biochem. Physiol.

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Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase

2008

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J. Med. Chem.

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Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors

2008

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J. Med. Chem.

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Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population

2008

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Pharmacogenet. Genomics

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Cloning and expression of carp acetylcholinesterase gene in Pichia pastoris and characterization of the recombinant enzyme

2009

Sato, R.; Matsumoto, T.; Hidaka, N.; Imai, Y.; Abe, K.; Takahashi, S.; Yamada, R.H.; Kera, Y.

Protein Expr. Purif.

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Glycoproteomic characterization of butyrylcholinesterase from human plasma

2008

Kolarich, D.; Weber, A.; Pabst, M.; Stadlmann, J.; Teschner, W.; Ehrlich, H.; Schwarz, H.P.; Altmann, F.

Proteomics

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Activity of essential oils and individual components against acetyl- and butyrylcholinesterase

2008

Orhan, I.; Kartal, M.; Kan, Y.; Sener, B.

Z. Naturforsch. C

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Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability

2010

Dillon, G.P.; Gaynor, J.M.; Khan, D.; Carolan, C.G.; Ryder, S.A.; Marquez, J.F.; Reidy, S.; Gilmer, J.F.

Bioorg. Med. Chem.

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Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase

2010

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Eur. J. Med. Chem.

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Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae)

2009

Menichini, F.; Tundis, R.; Loizzo, M.; Bonesi, M.; Marrelli, M.; Statti, G.; Menichini, F.; Conforti, F.

Fitoterapia

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A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques

2009

Elsinghorst, P.W.; Haertig, W.; Goldhammer, S.; Grosche, J.; Guetschow, M.

Org. Biomol. Chem.

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An evaluation of the inhibition of human butyrylcholinesterase and acetylcholinesterase by the organophosphate chlorpyrifos oxon

2009

Shenouda, J.; Green, P.; Sultatos, L.

Toxicol. Appl. Pharmacol.

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Substrate-inhibitory analysis of the cholinesterase in the freshwater oligochaete Lumbriculus variegatus (O.F. Mueller, 1773; Lumbriculidae, Oligochaeta)

2011

Chuiko, G.; Lapkina, L.; Podgornaya, V.

Biochem. Syst. Ecol.

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Localization and properties of cholinesterases in the common prawn (Palaemon serratus): A kinetic-histochemical study

2010

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Design, synthesis and evaluation of carbamate-modified (-)-N1-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors

2010

Takahashi, J.; Hijikuro, I.; Kihara, T.; Murugesh, M.; Fuse, S.; Tsumura, Y.; Akaike, A.; Niidome, T.; Takahashi, T.; Sugimoto, H.

Bioorg. Med. Chem. Lett.

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Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase

2010

Huang, L.; Luo, Z.; He, F.; Lu, J.; Li, X.

Bioorg. Med. Chem.

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Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors

2011

Chen, X.; Tikhonova, I.G.; Decker, M.

Bioorg. Med. Chem.

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Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine

2010

Yang, W.; Xue, L.; Fang, L.; Chen, X.; Zhan, C.

Chem. Biol. Interact.

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Pseudo-catalytic scavenging: Searching for a suitable reactivator of phosphorylated butyrylcholinesterase

2010

Kovarik, Z.; Katalinic, M.; Sinko, G.; Binder, J.; Holas, O.; Jung, Y.; Musilova, L.; Jun, D.; Kuca, K.

Chem. Biol. Interact.

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Cholinesterase activities and sensitivity to pesticides in different tissues of silver European eel, Anguilla anguilla

2011

Valbonesi, P.; Brunelli, F.; Mattioli, M.; Rossi, T.; Fabbri, E.

Comp. Biochem. Physiol. C

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Trypanosoma evansi: cholinesterase activity in acutely infected Wistar rats

2010

Wolkmer, P.; Lopes, S.T.; Franciscato, C.; da Silva, A.S.; Traesel, C.K.; Siqueira, L.C.; Pereira, M.E.; Monteiro, S.G.; Mazzanti, C.M.

Exp. Parasitol.

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Acetylcholinesterases of the cat flea Ctenocephalides felis: identification of two distinct genes and biochemical characterization of recombinant and in vivo enzyme activities

2010

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Insect Biochem. Mol. Biol.

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The characterization of Lucilia cuprina acetylcholinesterase as a drug target, and the identification of novel inhibitors by high throughput screening

2011

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Insect Biochem. Mol. Biol.

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Expression and characterization of recombinant Locusta migratoria manilensis acetylcholinesterase 1 in Pichia pastoris

2011

Zhou, X.; Xia, Y.

Protein Expr. Purif.

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Acetylcholinesterase of Stomoxys calcitrans (L.) (Diptera: Muscidae): cDNA sequence, baculovirus expression, and biochemical properties

2012

Temeyer, K.B.; Chen, A.C.

Vet. Parasitol.

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Optimal detection of cholinesterase activity in biological samples: Modifications to the standard Ellmans assay

2014

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Anal. Biochem.

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Characterization of cholinesterases in Chironomus riparius and the effects of three herbicides on chlorpyrifos toxicity

2013

Perez, J.; Monteiro, M.S.; Quintaneiro, C.; Soares, A.M.; Loureiro, S.

Aquat. Toxicol.

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Time-dependent kinetic complexities in cholinesterase-catalyzed reactions

2012

Masson, P.

Biochemistry

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Synthesis, characterization, and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors

2013

Yoon, Y.K.; Ali, M.A.; Wei, A.C.; Choon, T.S.; Khaw, K.Y.; Murugaiyah, V.; Osman, H.; Masand, V.H.

Bioorg. Chem.

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Relation between dynamics, activity and thermal stability within the cholinesterase family

2013

Trovaslet, M.; Trapp, M.; Weik, M.; Nachon, F.; Masson, P.; Tehei, M.; Peters, J.

Chem. Biol. Interact.

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The significance of low substrate concentration measurements for mechanistic interpretation in cholinesterases

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Stojan, J.

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QSAR, docking, dynamic simulation and quantum mechanics studies to explore the recognition properties of cholinesterase binding sites

2014

Correa-Basurto, J.; Bello, M.; Rosales-Hernandez, M.C.; Hernandez-Rodriguez, M.; Nicolas-Vazquez, I.; Rojo-Dominguez, A.; Trujillo-Ferrara, J.G.; Miranda, R.; Flores-Sandoval, C.A.

Chem. Biol. Interact.

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Characterization of catalytic efficiency parameters of brain cholinesterases in tropical fish

2014

de Assis, C.; Linhares, A.; Oliveira, V.; França, R.; Santos, J.; Marcuschi, M.; Maciel Carvalho, E.; Bezerra, R.; Carvalho Jr., L.

Fish Physiol. Biochem.

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Structural insights into cholinesterases inhibition by harmane beta-carbolinium derivatives: A kinetics-molecular modeling approach

2012

Torres, J.M.; Lira, A.F.; Silva, D.R.; Guzzo, L.M.; SantAnna, C.M.; Kuemmerle, A.E.; Rumjanek, V.M.

Phytochemistry

81

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Molecular and kinetic properties of two acetylcholinesterases from the western honey bee, Apis mellifera

2012

Kim, Y.H.; Cha, D.J.; Jung, J.W.; Kwon, H.W.; Lee, S.H.

PLoS ONE

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Design, synthesis and cellular characterization of a dual inhibitor of 5-lipoxygenase and soluble epoxide hydrolase

2016

Meirer, K.; Glatzel, D.; Kretschmer, S.; Wittmann, S.K.; Hartmann, M.; Bloecher, R.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Hofmann, B.; Fuerst, R.; Proschak, E.

Molecules

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Characterization of butyrylcholinesterase from porcine milk

2018

Saxena, A.; Belinskaya, T.; Schopfer, L.M.; Lockridge, O.

Arch. Biochem. Biophys.

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Purification and site-specific N-glycosylation analysis of human recombinant butyrylcholinesterase from Nicotiana benthamiana

2019

Alkanaimsh, S.; Corbin, J.; Kailemia, M.; Karuppanan, K.; Rodriguez, R.; Lebrilla, C.; McDonald, K.; Nandi, S.

Biochem. Eng. J.

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In vitro characterization of cationic copolymer-complexed recombinant human butyrylcholinesterase

2015

Pope, C.; Uchea, C.; Flynn, N.; Poindexter, K.; Geng, L.; Brimijoin, W.S.; Hartson, S.; Ranjan, A.; Ramsey, J.D.; Liu, J.

Biochem. Pharmacol.

98

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An investigation into the butyrylcholinesterase-catalyzed hydrolysis of formylthiocholine using heavy atom kinetic isotope effects

2016

Fogle, E.J.; Marlier, J.F.; Stillman, A.; Gao, X.; Rao, Y.; Robins, L.I.

Bioorg. Chem.

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Synthesis, crystal structure determination, biological screening and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases

2017

Sultana, N.; Sarfraz, M.; Tanoli, S.T.; Akram, M.S.; Sadiq, A.; Rashid, U.; Tariq, M.I.

Bioorg. Chem.

72

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Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with beta-amyloid anti-aggregation properties and beneficial effects on memory in vivo

2015

Wieckowska, A.; Wieckowski, K.; Bajda, M.; Brus, B.; Salat, K.; Czerwinska, P.; Gobec, S.; Filipek, B.; Malawska, B.

Bioorg. Med. Chem.

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Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property

2017

Liu, Z.; Fang, L.; Zhang, H.; Gou, S.; Chen, L.

Bioorg. Med. Chem.

25

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Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate

2017

Mohammed, A.; Sneathen, J.; Frojen, S.G.; Kuo, L.; Dupureur, C.M.

Bioorg. Med. Chem.

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Synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors

2017

Nakayama, K.; Schwans, J.P.; Sorin, E.J.; Tran, T.; Gonzalez, J.; Arteaga, E.; McCoy, S.; Alvarado, W.

Bioorg. Med. Chem.

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Purification, characterization, and N-glycosylation of recombinant butyrylcholinesterase from transgenic rice cell suspension cultures

2018

Corbin, J.M.; Kailemia, M.J.; Cadieux, C.L.; Alkanaimsh, S.; Karuppanan, K.; Rodriguez, R.L.; Lebrilla, C.B.; Cerasoli, D.M.; McDonald, K.A.; Nandi, S.

Biotechnol. Bioeng.

115

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750216

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Cholinesterases in Gambusia yucatana biochemical characterization and its relationship with sex and total length

2016

Rodriguez-Fuentes, G.; Marin-Lopez, V.; Hernandez-Marquez, E.

Bull. Environ. Contam. Toxicol.

97

776-780

750289

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Characterization of butyrylcholinesterase in bovine serum

2017

Dafferner, A.J.; Lushchekina, S.; Masson, P.; Xiao, G.; Schopfer, L.M.; Lockridge, O.

Chem. Biol. Interact.

266

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28322391

Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy

2017

Yang, S.H.; Sun, Q.; Xiong, H.; Liu, S.Y.; Moosavi, B.; Yang, W.C.; Yang, G.F.

Chem. Commun. (Camb.)

53

3952-3955

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26545490

The activity of detoxifying enzymes in the infective juveniles of Heterorhabditis bacteriophora strains purification and characterization of two acetylcholinesterases

2016

Mohamed, M.A.; Mahdy, e.l.-.S.M.; Ghazy, A.E.; Ibrahim, N.M.; El-Mezayen, H.A.; Ghanem, M.M.

Comp. Biochem. Physiol. C

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Suitability of cholinesterase of polychaete Diopatra neapolitana as biomarker of exposure to pesticides In vitro characterization

2017

Mennillo, E.; Casu, V.; Tardelli, F.; De Marchi, L.; Freitas, R.; Pretti, C.

Comp. Biochem. Physiol. C

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In-vitro evaluation and in-silico studies applied on newly synthesized amide derivatives of N-phthaloylglycine as butyrylcholinesterase (BChE) inhibitors

2018

Begum, S.; Nizami, S.S.; Mahmood, U.; Masood, S.; Iftikhar, S.; Saied, S.

Comput. Biol. Chem.

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Ferrocene-based anilides synthesis, structural characterization and inhibition of butyrylcholinesterase

2018

Altaf, A.A.; Hamayun, M.; Lal, B.; Tahir, M.N.; Holder, A.A.; Badshah, A.; Crans, D.C.

Dalton Trans.

47

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Characterization and in vitro sensitivity of cholinesterases of gilthead seabream (Sparus aurata) to organophosphate pesticides

2017

Albendin, G.; Arellano, J.M.; Manuel-Vez, M.P.; Sarasquete, C.; Arufe, M.I.

Fish Physiol. Biochem.

43

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Quantification of butyrylcholinesterase activity as a sensitive and specific biomarker of Alzheimers disease

2017

Macdonald, I.R.; Maxwell, S.P.; Reid, G.A.; Cash, M.K.; DeBay, D.R.; Darvesh, S.

J. Alzheimers Dis.

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Purification of recombinant human butyrylcholinesterase on Hupresin?

2018

Lockridge, O.; David, E.; Schopfer, L.M.; Masson, P.; Brazzolotto, X.; Nachon, F.

J. Chromatogr. B

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Evaluation of the inhibitory effect of abamectin on mammalian butyrylcholinesterase enzyme kinetic and molecular docking studies

2018

Terali, K.; Dalmizrak, O.; Hoti, Q.; Ozer, N.

J. Environ. Sci. Health B

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Substrate-inhibitor specificity of cholinesterase and monoamine oxydase from optic ganglia of the pacific squid Todarodes pacificus and commander squid Berryteuthis magister

2017

Rozengart, E.; Yagodina, O.; Basova, N.; Saakov, V.

J. Evol. Biochem. Physiol.

53

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30383374

Pyridinium oximes with ortho-positioned chlorine moiety exhibit improved physicochemical properties and efficient reactivation of human acetylcholinesterase inhibited by several nerve agents

2018

Zorbaz, T.; Malinak, D.; Marakovic, N.; Macek Hrvat, N.; Zandona, A.; Novotny, M.; Skarka, A.; Andrys, R.; Benkova, M.; Soukup, O.; Katalinic, M.; Kuca, K.; Kovarik, Z.; Musilek, K.

J. Med. Chem.

61

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751285

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The magic of crystal structure-based inhibitor optimization development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity

2018

Kosak, U.; Brus, B.; Knez, D.; Zakelj, S.; Trontelj, J.; Pislar, A.; Sink, R.; Jukic, M.; Zivin, M.; Podkowa, A.; Nachon, F.; Brazzolotto, X.; Stojan, J.; Kos, J.; Coquelle, N.; Salat, K.; Colletier, J.P.; Gobec, S.

J. Med. Chem.

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A new method to characterize the kinetics of cholinesterases inhibited by carbamates

2017

Xiao, Q.; Zhou, H.; Wei, H.; Du, H.; Tan, W.; Zhan, Y.; Pistolozzi, M.

J. Pharm. Biomed. Anal.

144

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Functional characterization of two acetylcholinesterase genes in the brown citrus aphid, Aphis (Toxoptera) citricidus (Kirkaldy), using heterologous expression and RNA interference

2017

Mou, X.; Yuan, G.R.; Jiang, H.B.; Liu, Z.; Wang, J.J.

Pestic. Biochem. Physiol.

138

76-83

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29321572

Specific inhibition of acetylcholinesterase as an approach to decrease muscarinic side effects during myasthenia gravis treatment

2018

Petrov, K.A.; Kharlamova, A.D.; Lenina, O.A.; Nurtdinov, A.R.; Sitdykova, M.E.; Ilyin, V.I.; Zueva, I.V.; Nikolsky, E.E.

Sci. Rep.

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Acetylcholinesterase in biofouling species characterization and mode of action of cyanobacteria-derived antifouling agents

2015

Almeida, J.R.; Freitas, M.; Cruz, S.; Leao, P.N.; Vasconcelos, V.; Cunha, I.

Toxins

7

2739-2756

Links to other databases for butyrylthiocholine

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