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BRENDA support

Ligand dimyristoylphosphatidylglycerol

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Basic Ligand Information

Molecular Structure
Picture of dimyristoylphosphatidylglycerol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C34H67O10P
dimyristoylphosphatidylglycerol
BPHQZTVXXXJVHI-IADGFXSZSA-N
Synonyms:
1,2-dimyristoyl-phosphatidylglycerol, 1,2-dimyristoylphosphatidylglycerol, 1,2-dimyristoyl phosphatidylglycerol

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CDP-dioleoylglycerol + 1,2-dimyristoylphosphatidylglycerol = 1-(1-oleoyl-2-oleoyl-sn-glycero-3-phospho)-3-(1-myristoyl-2-oleoyl-sn-glycero-3-phospho)-sn-glycerol + CMP
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates the arylesterase activity and inhibits paraoxonase activity
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activates mutant form lacking START domain
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solubilized ZntA is increased in the presence of negatively charged phospholipids and at slightly acidic pH. Among the most abundant naturally accuring phospholipids, only phosphatidyl-glycerol enhances the in vitro ATPase activity of TntA. Relipidation of detergent-purified ZntA with 1,2-dioleoylphosphatidyl-glycerol increases the ATPase activity 4fold compared to the purified state. Among the phosphatidylglycerol family, highest activity is observed for 1,2-dioleoyl-phosphatidylglycerol followed by 1,2-dimyristoyl-phosphatidylglycerol, 1,2-dipalmitoyl-phosphatidylglycerol and 1,2-distearoyl-phosphatidylglycerol
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates the arylesterase activity and inhibits paraoxonase activity
-

Enzyme Kinetic Parameters

References & Links

Links to other databases for dimyristoylphosphatidylglycerol

ChEBI
PubChem
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PubChem