We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Ligand dimyristoylphosphatidylglycerol Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C3 4 H6 7 O1 0 P
dimyristoylphosphatidylglycerol
BPHQZTVXXXJVHI-IADGFXSZSA-N
1,2-dimyristoyl-phosphatidylglycerol, 1,2-dimyristoylphosphatidylglycerol, 1,2-dimyristoyl phosphatidylglycerol
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CDP-dioleoylglycerol + 1,2-dimyristoylphosphatidylglycerol = 1-(1-oleoyl-2-oleoyl-sn-glycero-3-phospho)-3-(1-myristoyl-2-oleoyl-sn-glycero-3-phospho)-sn-glycerol + CMP
-
Activator in Enzyme-catalyzed Reactions (3 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
activates the arylesterase activity and inhibits paraoxonase activity
-
activates mutant form lacking START domain
-
solubilized ZntA is increased in the presence of negatively charged phospholipids and at slightly acidic pH. Among the most abundant naturally accuring phospholipids, only phosphatidyl-glycerol enhances the in vitro ATPase activity of TntA. Relipidation of detergent-purified ZntA with 1,2-dioleoylphosphatidyl-glycerol increases the ATPase activity 4fold compared to the purified state. Among the phosphatidylglycerol family, highest activity is observed for 1,2-dioleoyl-phosphatidylglycerol followed by 1,2-dimyristoyl-phosphatidylglycerol, 1,2-dipalmitoyl-phosphatidylglycerol and 1,2-distearoyl-phosphatidylglycerol
-
Inhibitor in Enzyme-catalyzed Reactions (2 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
activates the arylesterase activity and inhibits paraoxonase activity
-
Enzyme Kinetic Parameters
References & Links Literature References (4)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Phospholipid requirement and pH optimum for the in vitro enzymatic activity of the E. coli P-type ATPase ZntA
2006
Zimmer, J.; Doyle, D.A.
Biochim. Biophys. Acta
1758
645-652
Preferable stimulation of PON1 arylesterase activity by phosphatidylcholines with unsaturated acyl chains or oxidized acyl chains at sn-2 position
2006
Nguyen, S.D.; Sok, D.E.
Biochim. Biophys. Acta
1758
499-508
Identification and characterization of human cardiolipin synthase
2006
Houtkooper, R.H.; Akbari, H.; van Lenthe, H.; Kulik, W.; Wanders, R.J.; Frentzen, M.; Vaz, F.M.
FEBS Lett.
580
3059-3064
Enzymatic and transcriptional regulation of the cytoplasmic acetyl-CoA hydrolase ACOT12
2013
Horibata, Y.; Ando, H.; Itoh, M.; Sugimoto, H.
J. Lipid Res.
54
2049-2059
Links to other databases for dimyristoylphosphatidylglycerol