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BRENDA support

Ligand rhamnetin

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Basic Ligand Information

Molecular Structure
Picture of rhamnetin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C16H12O7
rhamnetin
JGUZGNYPMHHYRK-UHFFFAOYSA-N
Synonyms:
2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-chromen-4-one, 3-methoxyquercetin, 7-methoxyquercetin, 7-methylquercetin, 7-methyl quercetin, 7-O-methylquercetin, 7-O-methyl quercetin

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + quercetin = S-adenosyl-L-homocysteine + 7-O-methylquercetin
show the reaction diagram
-
S-adenosyl-L-methionine + quercetin = S-adenosyl-L-homocysteine + 7-O-methylquercetin
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + 7-methylquercetin = ?
show the reaction diagram
-
UDPglucose + rhamnetin = UDP + rhamnetin 3-O-glucoside
show the reaction diagram
-
UDP-alpha-D-xylose + rhamnetin = UDP + rhamnetin 3-O-beta-D-xyloside
show the reaction diagram
-
3'-phosphoadenylylsulfate + rhamnetin = adenosine 3',5'-bisphosphate + rhamnetin 3-sulfate
show the reaction diagram
-
adenosine 3'-phosphate 5'-phosphosulfate + rhamnetin = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + quercetin = 7-O-methylquercetin
show the reaction diagram
-
S-adenosyl-L-methionine + quercetin = S-adenosyl-L-homocysteine + 7-O-methylquercetin
show the reaction diagram
-
S-adenosyl-L-methionine + quercetin = S-adenosyl-L-homocysteine + 7-O-methylquercetin
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
remarkable noncompetitive inhibition
-
a flavonol, 0.888 mM, pH 6.0, room temperature, 8.1% maximum inhibition
-
0.1 mM, about 50% inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0002
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0058
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.832
-
pH 9.5, 37°C, activity in promastigote

References & Links

Links to other databases for rhamnetin

ChEBI
PubChem
ChEBI
PubChem