Ligand Pro-Ala

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Basic Ligand Information

Molecular Structure
Picture of Pro-Ala (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H14N2O3
Pro-Ala
FELJDCNGZFDUNR-WDSKDSINSA-N
Synonyms:
L-Pro-L-Ala, L-prolyl-L-alanine

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
Z-Gly-Pro-Gly-Gly-Pro-Ala + H2O = Z-Gly-Pro + Gly-Gly + L-Pro-L-Ala
-

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
Pro-Ala + H2O = Pro + Ala
-

Product in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
Pro-Ala-p-nitroanilide + H2O = Pro-Ala + p-nitroaniline
-
-
show the reaction diagram
Z-Gly-Pro-Gly-Gly-Pro-Ala + H2O = Z-Gly-Pro + Gly-Gly + L-Pro-L-Ala
-
-
show the reaction diagram
Z-Gly-Pro-Gly-Gly-Pro-Ala + H2O = Z-Gly-Pro + Gly + Gly + L-Pro-L-Ala
-
-
show the reaction diagram
ATP + L-proline + L-alanine = ADP + phosphate + L-prolyl-L-alanine
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
competitive to hydrolysis of Gly-Leu
-
hydrolysis of Gly-Pro-4-nitroanilide
-
hydrolysis of L-Pro-L-Ala
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
pH 8.0, 37°C, wild-type enzyme
16.8
-

KM Value (4 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
-
2.69
-
pH 7.5, 30°C
0.31
-
pH 8.0, 37°C, wild-type enzyme
2.07
-
at pH 8.0 and 9.2
0.47
-

References & Links

Links to other databases for Pro-Ala

ChEBI
PubChem
-
PubChem