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Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium
1993
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Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid
1990
Crouzet, J.; Cameron, B.; Cauchois, L.; Rigault, S.; Rouyez, M.C.; Blanche, F.; Thibaut, D.; Debussche, L.
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Biosynthesis of vitamin B12: the preparative multi-enzyme synthesis of precorrin-3A and 20-methylsirohydrochlorin (a 2,7,20-trimethylisobacteriochlorin)
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Enzymatic synthesis and structure of precorrin-3, a trimethyldipyrrocorphin intermediate in vitamin B12 biosynthesis
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Biochemistry
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Assay and purification of S-adenosyl-L-methionine:precorrin-2 methyltransferase from Pseudomonas denitrificans
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Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis
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Roessner, C.A.; Warren, M.J.; Santander, P.J.; Atshaves, B.P.; Ozaki, S.i.; Stolowich, N.J.; Iida, K.
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Uroporpyrinogen III methylase catalyzes the enzymatic synthesis of sirohydrochlorines II and IV by a clockwise mechanism
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The Escherichia coli cysG gene encodes S-adenosylmethionine-dependent uroporphyrinogen III methylase
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Purification and characterization of S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase from Pseudomonas denitrificans
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Nucleotide sequence of a Pseudomonas denitrificans 5.4-kilobase DNA fragment containing five cob genes and identification of structural genes encoding S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase and cobyrinic acid a,c-diamide synthase
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Cloning, sequencing, and expression of the uroporphyrinogen III methyltransferease cobA gene of Propionibacterium freudenreichii (shermanii)
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Reddish Escherichia coli cells caused by overproduction of Bacillus stearothermophilus uroporphyrinogen III methylase: cloning, sequencing, and expression of the gene
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Isolation and characterization of a cDNA that encodes maize uroporphyrinogen III methyltransferase, an enzyme involved in the synthesis of siroheme, which is a prosthetic group of nitrite reductase
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Siroheme biosynthesis in higher plants. Analysis of an S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase from Arabidopsis thaliana
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Effect of mutations in the transmethylase and dehydrogenase/chelatase domains of siroheme synthase (CysG) on siroheme and cobalamin biosynthesis
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The role of Saccharomyces cerevisiae MET1p and MET8p in sirohaem and cobalamin biosynthesis
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The biosynthesis of adenosylcobalamin (vitamin B12)
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The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase
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Common chelatase design in the branched tetrapyrrole pathways of heme and anaerobic cobalamin synthesis
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Biochemistry
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Gene dissection demonstrates that the Escherichia coli cysG gene encodes a multifunctional protein
1994
Warren, M.J.; Bolt, E.L.; Roessner, C.A.; Scott, A.I.; Spencer, J.B.; Woodcock, S.C.
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Identification and functional analysis of enzymes required for precorrin-2 dehydrogenation and metal ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus megaterium
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Raux, E.; Leech, H.K.; Beck, R.; Schubert, H.L.; Santander, P.J.; Roessner, C.A.; Scott, A.I.; Martens, J.H.; Jahn, D.; Thermes, C.; Rambach, A.; Warren, M.J.
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Structural diversity in metal ion chelation and the structure of uroporphyrinogen III synthase
2002
Schubert, H.L.; Raux, E.; Matthews, M.A.; Phillips, J.D.; Wilson, K.S.; Hill, C.P.; Warren, M.J.
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Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum
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Evidence that the CysG protein catalyzes the first reaction specific to B12 synthesis in Salmonella typhimurium, insertion of cobalt
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A cysG mutant strain of Rhizobium etli pleiotropically defective in sulfate and nitrate assimilation
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CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis
2003
Stroupe, M.E.; Leech, H.K.; Daniels, D.S.; Warren, M.J.; Getzoff, E.D.
Nat. Struct. Biol.
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Structure and function of SirC from Bacillus megaterium - a metal binding precorrin-2 dehydrogenase
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Schubert, H.L.; Rose, R.S.; Leech, H.K.; Brindley, A.A.; Hill, C.P.; Rigby, S.E.; Warren, M.J.
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Coupled selection of protein solubility in E. coli using uroporphyrinogen III methyltransferase as red fluorescent reporter
2014
Wang, Z.; Yan, H.; Li, S.; Zhang, K.; Cheng, B.; Fan, J.
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Identification of the sirohaem biosynthesis pathway in Staphylococcus aureus
2020
Videira, M.A.M.; Lobo, S.A.L.; Sousa, F.L.; Saraiva, L.M.
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Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site
2020
Pennington, J.; Kemp, M.; McGarry, L.; Chen, Y.; Stroupe, M.
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