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Ligand nonanoyl-CoA

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.2.20

nonanoyl-CoA + H2O = nonanoate + CoA

665707

-

Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Substrate (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.3.6

nonanoyl-CoA + O2 = trans-2-nonenoyl-CoA + H2O2

391042

-

1.3.8.7

nonanoyl-CoA + oxidized electron transfer flavoprotein = ? + reduced electron transfer flavoprotein

674476

-

2.3.1.42

nonanoyl-CoA + dihydroxyacetone phosphate = CoA + nonanoyldihydroxyacetone phosphate

486950

-

3.1.2.19

nonanoyl-CoA + H2O = CoA + nonanoate

646112, 646111

-

3.1.2.20

nonanoyl-CoA + H2O = nonanoate + CoA

665707

-

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.2.1.12

ATP + nonanoate + CoA = AMP + diphosphate + nonanoyl-CoA

0

-

6.2.1.3

ATP + nonanoate + CoA = AMP + diphosphate + nonanoyl-CoA

0

-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

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Show Inhibitors (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.3.10

-

488091

-

3.1.2.17

noncompetitive inhibition

643853

-

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.2.20

0.0218

-

pH 8.0

665707

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.3.10

0.004

-

pH 8.0

488091

3.1.2.17

0.2

-

pH 6.0, 30°C

643853

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

391042

7462191

Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase

1980

Kawaguchi, A.; Tsubotani, S.; Seyama, Y.; Yamakawa, T.; Osumi, T.; Hashimoto, T.; Kikuchi, T.; Ando, M.; Okuda, S.

J. Biochem.

88

1481-1486

486950

5656381

Biosynthesis of acyl dihydroxyacetone phosphate in guinea pig liver mitochondria

1968

Hajra, A.

J. Biol. Chem.

243

3458-3465

488091

4561618

The kinetic mechanism of 3-hydroxy-3-methylglutaryl-coenzyme a synthase from baker's yeast

1972

Middleton, B.

Biochem. J.

126

35-47

643853

6885824

Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme A hydrolase

1983

Kovachy, R.J.; Copley, S.D.; Allen, R.H.

J. Biol. Chem.

258

11415-11421

646111

2901416

A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria

1988

Alexson, S.E.H.; Nedergard, J.

J. Biol. Chem.

263

13564-13571

646112

2570608

NADH-sensitive propionyl-CoA hydrolase in brown adipose tissue mitochondria of the rat

1989

Alexson, S.E.H.; Svensson, L.T.; Nedergaard, J.

Biochim. Biophys. Acta

1005

13-19

665707

16490786

The peroxisomal acyl-CoA thioesterase Pte1p from Saccharomyces cerevisiae is required for efficient degradation of short straight chain and branched chain fatty acids

2006

Maeda, I.; Delessert, S.; Hasegawa, S.; Seto, Y.; Zuber, S.; Poirier, Y.

J. Biol. Chem.

281

11729-11735

674476

16020546

Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial beta-oxidation of unsaturated fatty acids

2005

Ensenauer, R.; He, M.; Willard, J.M.; Goetzman, E.S.; Corydon, T.J.; Vandahl, B.B.; Mohsen, A.W.; Isaya, G.; Vockley, J.

J. Biol. Chem.

280

32309-32316

Links to other databases for nonanoyl-CoA

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Show Links (1 entry)

ChEBI

PubChem