Ligand glutaryl-CoA

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of glutaryl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C26H42N7O19P3S
glutaryl-CoA
SYKWLIJQEHRDNH-CKRMAKSASA-N
Synonyms:
glutaryl CoA, pentanedioyl-CoA, proteo-glutaryl-CoA


Show all pahtways known for Show all BRENDA pathways known for glutaryl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glutaryl-CoA + FAD = glutaconyl-CoA + FADH2
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + butyryl-CoA + HCO3- + H+ = ADP + glutaryl-CoA + phosphate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glutaryl-CoA + NADPH + H+ = ? + coenzyme A + NADP+
show the reaction diagram
-
glutaryl-CoA + FAD = glutaconyl-CoA + FADH2
show the reaction diagram
-
glutaryl-CoA + pelargonidin 3-O-beta-D-glucoside = CoA + pelargonidin 3-O-(6-O-glutaryl-beta-D-glucoside)
show the reaction diagram
-
glutaryl-CoA + L-homoserine = CoA + O-glutaryl-L-homoserine
show the reaction diagram
-
glutaryl-CoA + glycine = ? + CoA + CO2
show the reaction diagram
-
glutaryl-CoA + L-homoserine = CoA + O-glutaryl-L-homoserine
show the reaction diagram
-
glutaryl-CoA + kanamycin A = ?
show the reaction diagram
-
glutaryl-CoA + acetate = glutarate + acetyl-CoA
show the reaction diagram
-
glutaryl-CoA = glutarate + CoA
show the reaction diagram
-
glutaryl-CoA + H2O = CoA + glutarate
show the reaction diagram
-
glutaryl-CoA + H2O = CoA + glutarate
show the reaction diagram
-
glutaryl-CoA + Na+[side 1] = butyryl-CoA + CO2 + Na+[side 2]
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glutaraldehyde + CoA + NAD+ = glutaryl-CoA + NADH
show the reaction diagram
-
-
2-oxoadipate + CoA + NAD+ = glutaryl-CoA + CO2 + NADH
show the reaction diagram
-
-
2-oxoadipate + CoA + 2 methyl viologen = glutaryl-CoA + CO2 + 2 reduced methyl viologen + 2 H+
show the reaction diagram
-
-
glutaconyl-CoA + glutarate = glutaconate + glutaryl-CoA
show the reaction diagram
-
succinyl-CoA + glutarate = glutaryl-CoA + succinate
show the reaction diagram
-
-
ATP + glutarate + CoA = AMP + diphosphate + glutaryl-CoA
show the reaction diagram
-
-
ATP + pentanedioic acid + CoA = AMP + diphosphate + pentanedioyl-CoA
show the reaction diagram
-
-
ATP + glutarate + CoA = AMP + diphosphate + glutaryl-CoA
show the reaction diagram
-
ATP + glutarate + CoA = ADP + phosphate + glutaryl-CoA
show the reaction diagram
-
-
ATP + butyryl-CoA + HCO3- + H+ = ADP + glutaryl-CoA + phosphate
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 50% residual activity at 2.5 mM
-
0.1 mM, 34% inhibtion
-
competitive inhibition
-
at 1 mM 42% inhibition of activity (concentrations of substrates 1 mM)
-
competitive to glutaconyl-CoA
-

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (24 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.25
-
25°C, pH 7.5
1.6
-
recombinant protein

KM Value (37 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.18
-
recombinant protein
37.1
-
-
3
5
28°C, pH 7.5

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.11
-
pH 8.0
4.9
-
pH 6.0, 30°C
0.0074
-
-

References & Links

Links to other databases for glutaryl-CoA

ChEBI
PubChem
-
PubChem