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Ligand leukotriene D4

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for leukotriene D4

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.13.19

leukotriene D4 + H2O = ?

647114

-

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.11.1

leukotriene D4 + H2O = ?

650477

-

3.4.13.19

leukotriene D4 + H2O = ?

647113, 647114

-

3.4.13.19

leukotriene D4 + H2O = leukotriene E4

678065

-

3.4.13.19

2 entries

7.6.2.2

ATP + H2O + leukotriene D4[side 1] = ADP + phosphate + leukotriene D4[side 2]

747619

-

Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.2

leukotriene C4 + acceptor = leukotriene D4 + glutamyl-acceptor

487928, 487929

-

2.3.2.2

leukotriene C4 + glycylglycine = leukotriene D4 + 5-L-glutamyl-glycylglycine

0

-

2.3.2.2

2 entries

3.4.19.14

leukotriene C4 + H2O = leukotriene D4 + L-glutamate

0

-

7.6.2.2

ATP + H2O + leukotriene D4[side 1] = ADP + phosphate + leukotriene D4[side 2]

0

-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

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Show Inhibitors (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

4.4.1.20

-

644504

-

7.6.2.2

competitive

210398

-

7.6.2.2

transport of aflatoxin B1-epoxide-GSH conjugate

210401

-

7.6.2.2

2 entries

Enzyme Kinetic Parameters

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.4.13.19

0.005

-

membrane-bound dipeptidase-2

647113

3.4.13.19

0.01

-

membrane-bound dipeptidase-1

647113

3.4.13.19

2 entries

References & Links

Literature References (10)

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Show Reference (10 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

210398

8692921

ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles estabilshes MRP as a broad specificity transporter

1996

Paul, S.; Breuninger, L.M.; Tew, K.D.; Shen, H.; Kruh, G.D.

Proc. Natl. Acad. Sci. USA

93

6929-6934

210401

9187270

ATP-dependent transport of aflatoxin B1 and its glutathione conjugate by the product of the multidrug resistance protein (MRP) gene

1997

Loe, D.W.; Stewart, R.K.; Massey, T.E.; Deeley, R.G.; Cole, S.P.C.

Mol. Pharmacol.

51

1034-1041

487928

6126192

Kinetics of the conversion of leukotriene C by gamma-glutamyl transpeptidase

1982

Írning, L.; Hammarström, S.

Biochem. Biophys. Res. Commun.

106

1304-1309

487929

6127596

gamma-Glutamyl transpeptidase, a leukotriene metabolizing enzyme

1982

Bernström, K.; Orning, L.; Hammarström, S.

Methods Enzymol.

86

38-45

644504

1425677

Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells

1992

Nicholson, D.W.; Klemba, M.W.; Rasper, D.M.; Metters, K.M.; Zamboni, R.J.

Eur. J. Biochem.

209

725-734

647113

12738806

Identification of two additional members of the membrane-bound dipeptidase family

2003

Habib, G.M.; Shi, Z.Z.; Cuevas, A.A.; Lieberman, M.W.

FASEB J.

17

1313-1315

647114

9337849

Identification by site-directed mutagenesis of three essential histidine residues in membrane dipeptidase, a novel mammalian zinc peptidase

1997

Keynan, S.; Hooper, N.M.; Turner, A.J.

Biochem. J.

326

47-51

650477

12675513

Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver

2003

Jösch, C.; Klotz, L.O.; Sies, H.

Biol. Chem.

384

213-218

678065

17623009

Biosynthesis and metabolism of leukotrienes

2007

Murphy, R.C.; Gijon, M.A.

Biochem. J.

405

379-395

747619

29022498

ATP-binding cassette exporters structure and mechanism with a focus on P-glycoprotein and MRP1

2017

Arana, M.R.; Altenberg, G.

Curr. Med. Chem.

25

1-17

Links to other databases for leukotriene D4

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Show Links (1 entry)

ChEBI

PubChem