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Ligand ethylmalonyl-CoA

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (7 results)

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Show Substrate (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.226

ethylmalonyl-CoA + (2S,5S)-carboxymethylproline + CO2 = CoA + (2S,5S,6R)-6-ethyl-5-carboxymethylproline

723252

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2.3.1.226

ethylmalonyl-CoA + (2S,5S)-carboxymethylproline + CO2 = CoA + (2S,5S,6S)-6-ethyl-5-carboxymethylproline

723252

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2.3.1.226

ethylmalonyl-CoA + L-2-aminoadipate semialdehyde = CoA + (2S,6S,7R)-7-ethyl-carboxymethylpipecolic acid

723252

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2.3.1.226

ethylmalonyl-CoA + L-2-aminoadipate semialdehyde = CoA + (2S,6S,7S)-7-ethyl-carboxymethylpipecolic acid

723252

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2.3.1.226

4 entries

2.3.1.B32

ethylmalonyl-CoA + an [acyl-carrier protein] = CoA + a methylmalonyl-[acyl-carrier protein]

735679

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5.4.99.2

Ethylmalonyl-CoA = (2R)-Methylsuccinyl-CoA

3519

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5.4.99.2

ethylmalonyl-CoA = methylsuccinyl-CoA

3513

-

5.4.99.2

2 entries

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.3.1

butyryl-CoA + oxaloacetate = ethylmalonyl-CoA + pyruvate

485817, , 485816

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6.4.1.2

ATP + butyryl-CoA + HCO3- = ADP + ethylmalonyl-CoA + phosphate

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Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

5.4.99.2

competitive with wild-type, O2-dependent suicide inactivation with mutant Y243A

678179

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Enzyme Kinetic Parameters

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

5.4.99.2

0.0153

-

mutant Y243A, pH 7.0, 37°C

678179

5.4.99.2

0.467

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wild-type, pH 7.0, 37°C

678179

5.4.99.2

2 entries

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

3513

7989334

Inhibition of the human methylmalonyl-CoA mutase by various CoA-esters

1994

Taoka, S.; Padmakumar, R.; Lai, M.; Liu, H.; Banerjee, R.

J. Biol. Chem.

269

31630-31634

3519

24538

Investigation of the mechanism of the methylmalonyl-CoA mutase reaction with the substrate analogue: ethylmalonyl-CoA

1978

Retey, J.; Smith, E.H.; Zagalak, B.

Eur. J. Biochem.

83

437-451

485816

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Transcarboxylase

1972

Wood, H.G.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

6

83-115

485817

16590594

The role of transcarboxylase in propionic acid ermentation

1960

Swick, R.W.; Wood, H.G.

Proc. Natl. Acad. Sci. USA

46

28-41

678179

16503649

Alternative pathways for radical dissipation in an active site mutant of B12-dependent methylmalonyl-CoA mutase

2006

Padovani, D.; Banerjee, R.

Biochemistry

45

2951-2959

723252

21505494

Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases

2011

Hamed, R.B.; Gomez-Castellanos, J.R.; Thalhammer, A.; Harding, D.; Ducho, C.; Claridge, T.D.; Schofield. C.J.

Nat. Chem.

3

365-371

735679

24871074

Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases

2014

Dunn, B.J.; Watts, K.R.; Robbins, T.; Cane, D.E.; Khosla, C.

Biochemistry

53

3796-3806

Links to other databases for ethylmalonyl-CoA

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Show Links (1 entry)

ChEBI

PubChem

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