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Isomerization of 6-lactoyl tetrahydropterin by sepiapterin reductase
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Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase
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Purification and characterization of 6-pyruvoyl tetrahydropterin synthase from human pituitary gland
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Biosynthesis of biopterin studies on the mechanism of 6-pyruvoyltetrahydropteridine synthase
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cDNA cloning, expression in Escherichia coli and purification of human 6-pyruvoyl-tetrahydropterin synthase
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Expression and characterization of recombinant human and rat liver 6-pyruvoyl tetrahydropterin synthase. Modified cysteine residues inhibit the enzyme activity
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Structural and functional consequences of mutations in 6-pyruvoyltetrahydropterin synthase causing hyperphenylalaninemia in humans
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Purification and characterization of 6-pyruvoyl tetrahydropterin synthase from salmon liver
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Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from Drosophila melanogaster
1990
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Escherichia coli 6-pyruvoyltetrahydropterin synthase ortholog encoded by ygcM has a new catalytic activity for conversion of sepiapterin to 7,8-dihydropterin
2002
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Serine 19 of human 6-pyruvoyltetrahydropterin synthase is phosphorylated by cGMP protein kinase II
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Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase
2003
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Production of sepiapterin in Escherichia coli by coexpression of cyanobacterial GTP cyclohydrolase I and human 6-pyruvoyltetrahydropterin synthase
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Biosynthesis of pteridines. NMR studies on the reaction mechanisms of GTP cyclohydrolase I, pyruvoyltetrahydropterin synthase, and sepiapterin reductase
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Regulation of 6-pyruvoyltetrahydropterin synthase activity and messenger RNA abundance in human vascular endothelial cells
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Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase
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Effect of antisense oligodeoxynucleotide for sepiapterin reductase on the viability of PC12 cells in the presence of exogenous carbonyl compounds
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Sepiapterin reductases from Chlorobium tepidum and Chlorobium limicola catalyze the synthesis of L-threo-tetrahydrobiopterin from 6-pyruvoyltetrahydropterin
2005
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The clot gene of Drosophila melanogaster encodes a conserved member of the thioredoxin-like protein superfamily
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Mol. Genet. Genomics
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Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum
2005
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Acta Crystallogr. Sect. F
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Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2
2006
Choi, Y.K.; Kong, J.S.; Park, Y.S.
Biochim. Biophys. Acta
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D-threo-tetrahydrobiopterin is synthesized via 1-oxo-2-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum Ax2
2005
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Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin
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Identification and characteristics of the structural gene for the Drosophila eye colour mutant sepia, encoding PDA synthase, a member of the Omega class glutathione S-transferases
2006
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A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice - as a mouse model for Parkinsons disease
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Takazawa, C.; Fujimoto, K.; Homma, D.; Sumi-Ichinose, C.; Nomura, T.; Ichinose, H.; Katoh, S.
Biochem. Biophys. Res. Commun.
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Sepiapterin reductase expression is increased in Parkinsons disease brain tissue
2007
Tobin, J.E.; Cui, J.; Wilk, J.B.; Latourelle, J.C.; Laramie, J.M.; McKee, A.C.; Guttman, M.; Karamohamed, S.; DeStefano, A.L.; Myers, R.H.
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Regulation of tetrahydrobiopterin biosynthesis by shear stress
2007
Widder, J.D.; Chen, W.; Li, L.; Dikalov, S.; Thoeny, B.; Hatakeyama, K.; Harrison, D.G.
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Tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2
2007
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Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin
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Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin
2008
Supangat, S.; Park, S.O.; Seo, K.H.; Lee, S.Y.; Park, Y.S.; Lee, K.H.
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Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues
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Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder
2009
McHugh, P.C.; Joyce, P.R.; Kennedy, M.R.
Pharmacogenet. Genomics
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Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase
2009
McCarty, R.M.; Somogyi, A.; Bandarian, V.
Biochemistry
48
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Show all BRENDA pathways known for 6-pyruvoyltetrahydropterin
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