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Ligand 5-methylcytosine
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Basic Ligand Information
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open all tablesRoles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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EC NUMBER 
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Substrate in Enzyme-catalyzed Reactions (5 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Product in Enzyme-catalyzed Reactions (2 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-methylcytosine-mismatched double-stranded DNA + H2O = 5-methylcytosine + double-stranded DNA with abasic site
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Activator in Enzyme-catalyzed Reactions (1 result)
EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
preference for single stranded DNA substrates is increased up to 50fold by the presence of a proximal 5-methyl cytosine. This modulation is distance-dependent and is due to an enhanced binding affinity and minor changes in catalytic efficiency. No modulation of activity is observed with double stranded DNA
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)
Enzyme Kinetic Parameters
KM Value (4 results)
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
References & Links
Literature References (18)
Links to other databases for 5-methylcytosine
ChEBI
PubChem
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Release 2023.1 (January 2023)
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