Ligand 5-Methylcytosine

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Basic Ligand Information

Molecular Structure
Picture of 5-Methylcytosine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H7N3O
5-Methylcytosine
IMXSCCDUAFEIOE-RITPCOANSA-N
Synonyms:
5-methyl cytosine
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-methylcytosine + H2O = thymine + NH3
show the reaction diagram

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-methylcytosine-mismatched double-stranded DNA + H2O = 5-methylcytosine + double-stranded DNA with abasic site
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-methylcytosine + 2-oxoglutarate + O2 = ?
show the reaction diagram
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5-methylcytosine + H2O = thymine + NH3
show the reaction diagram
5-methylcytosine + H2O = 5-methyluracil + NH3
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-methylcytosine-mismatched double-stranded DNA + H2O = 5-methylcytosine + double-stranded DNA with abasic site
show the reaction diagram
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5-methylcytosine-mismatched double-stranded DNA + H2O = 5-methylcytosine + double-stranded DNA with abasic site
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
preference for single stranded DNA substrates is increased up to 50fold by the presence of a proximal 5-methyl cytosine. This modulation is distance-dependent and is due to an enhanced binding affinity and minor changes in catalytic efficiency. No modulation of activity is observed with double stranded DNA
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for 5-Methylcytosine

ChEBI
PubChem
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PubChem