Ligand 5-hydroxytryptophol
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Basic Ligand Information
Molecular Structure

C10H11NO2
5-hydroxytryptophol
KQROHCSYOGBQGJ-UHFFFAOYSA-N
Show all BRENDA pathways known for 5-hydroxytryptophol
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (6 results)
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5-hydroxytryptophol + Fe2+ + O2 = ?
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UDP-glucuronate + 5-hydroxytryptophol = UDP + 5-hydroxy-tryptophol beta-D-glucuronoside
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UDP-glucuronate + 5-hydroxytryptophol = UDP + 5-hydroxytryptophol beta-D-glucuronide
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UDP-glucuronate + 5-hydroxytryptophol = UDP + 5-hydroxytryptophol beta-D-glucuronoside
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3'-phosphoadenylylsulfate + 5-hydroxytryptophol = adenosine 3',5'-bisphosphate + ?
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3'-phosphoadenylylsulfate + 5-hydroxytryptophol = adenosine 3',5'-bisphosphate + ?
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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competitive inhibition of serotonin glucuronidation
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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KM Value (4 results)
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0.135
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isozyme UGT1A6, pH 7.5, 37°C
3.674
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isozyme UGT1A9, pH 7.5, 37°C
Ki Value (2 results)
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0.2
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isozyme UGT1A6, pH 7.5, 37°C
0.29
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liver microsomes, pH 7.5, 37°C
References & Links
Literature References (5)
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Ceruloplasmin: the copper transport protein with essential oxidase activity
1976
Frieden, E.; Hsieh, H.S.
Adv. Enzymol. Relat. Areas Mol. Biol.
44
187-236
Aryl sulfotransferase IV from rat liver
1981
Sekura, R.D.; Jakoby, W.B.
Arch. Biochem. Biophys.
211
352-359
Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms
2001
Honma, W.; Kamiyama, Y.; Yoshinari, K.; Sasano, H.; Shimada, M.; Nagata, K.; Yamazoe, Y.
Drug Metab. Dispos.
29
274-281
Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6
2004
Krishnaswamy, S.; Hao, Q.; Von Moltke, L.L.; Greenblatt, D.J.; Court, M.H.
Drug Metab. Dispos.
32
862-869
Roles of human UDP-glucuronosyltransferases in clearance and homeostasis of endogenous substrates, and functional implications
2015
Bock, K.W.
Biochem. Pharmacol.
96
77-82
Links to other databases for 5-hydroxytryptophol