Ligand view of 5-chlorouracil (6459 - ZFTBZKVVGZNMJR-UHFFFAOYSA-N)

C₄H₃ClN₂O₂

5-chlorouracil

ZFTBZKVVGZNMJR-UHFFFAOYSA-N

3.2.2.29

5-chlorouracil-mismatched double-stranded DNA + H2O = 5-chlorouracil + double-stranded DNA with abasic site

0

-

2.4.2.6

2'-deoxyadenosine + 5-chlorouracil = 2'-deoxy-D-ribosyl-5-chlorouracil + adenine

673396, 721340, 721371

-

1.11.1.10

uracil + Cl- + H2O2 = 5-chlorouracil + H2O

348310

-

2.4.2.2

5-chlorodeoxyuridine + phosphate = 5-chlorouracil + 2-deoxy-D-ribose 1-phosphate

0

-

2.4.2.9

5-chloro-UMP + diphosphate = 5-chlorouracil + 5-phospho-alpha-D-ribose 1-diphosphate

0

-

3.2.2.29

5-chlorouracil-mismatched double-stranded DNA + H2O = 5-chlorouracil + double-stranded DNA with abasic site

0

-

3.5.4.1

5-chlorocytosine + H2O = 5-chlorouracil + NH3

0

-

1.3.3.7

competitive vs. dihydrouracil

-

-

-

IC50: 0.27 mM

-

0.1 mM

-

0.02

-

391073

2.4.2.30

0.27

-

IC50: 0.27 mM

637997

348310

-

Haloperoxidase-catalyzed halogenation of nitrogen-containing aromatic heterocycles represented by nucleic bases

1987

Itoh, N.; Izumi, Y.; Yamada, H.

Biochemistry

26

282-289

391073

-

Partial purification and characterization of dihydrouracil oxidase, a flavoprotein from Rhodotorula glutinis

1986

Owaki, J.; Uzura, K.; Minami, Z.; Kuai, K.

J. Ferment. Technol.

64

205-210

489712

692383

Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell)

1978

Jones, M.E.; Kavipurapu, P.R.; Traut, T.W.

Methods Enzymol.

51

155-167

637062

1633195

Inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by 5-fluorouracil and alpha-fluoro-beta-alanine

1992

Kaneko, M.; Kontani, Y.; Kikugawa, M.; Tamaki, N.

Biochim. Biophys. Acta

1122

45-49

637997

1530940

Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase

1992

Banasik, M.; Komura, H.; Shimoyama, M.; Ueda, K.

J. Biol. Chem.

267

1569-1575

673396

-

Synthesis of 2-deoxyibosylnucleosides using new 2-deoxyribosyltransferase microorganism producers

2007

Fernandez-Lucas, J.; Condezo, L.A.; Martinez-Lagos, F.; Sinisterra, J.V.

Enzyme Microb. Technol.

40

1147-1155

721340

20048065

Lactobacillus reuteri 2-deoxyribosyltransferase, a novel biocatalyst for tailoring of nucleosides

2010

Fernandez-Lucas, J.; Acebal, C.; Sinisterra, J.V.; Arroyo, M.; de la Mata, I.

Appl. Environ. Microbiol.

76

1462-1470

721371

21476139

Enzymatic synthesis of nucleoside analogues using immobilized 2-deoxyribosyltransferase from Lactobacillus reuteri

2011

Fernandez-Lucas, J.; Fresco-Taboada, A.; Acebal, C.; de la Mata, I.; Arroyo, M.

Appl. Microbiol. Biotechnol.

91

317-327

Ligand 5-chlorouracil

Basic Ligand Information

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

Substrate in Enzyme-catalyzed Reactions (1 result)

Product in Enzyme-catalyzed Reactions (5 results)

Inhibitor in Enzyme-catalyzed Reactions (4 results)

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

Enzyme Kinetic Parameters

K_i Value (1 result)

IC₅₀ Value (1 result)

References & Links

Literature References (8)

Links to other databases for 5-chlorouracil

Ligand 5-chlorouracil

Basic Ligand Information

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

Substrate in Enzyme-catalyzed Reactions (1 result)

Product in Enzyme-catalyzed Reactions (5 results)

Inhibitor in Enzyme-catalyzed Reactions (4 results)

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

Enzyme Kinetic Parameters

Ki Value (1 result)

IC50 Value (1 result)

References & Links

Literature References (8)

Links to other databases for 5-chlorouracil

K_i Value (1 result)

IC₅₀ Value (1 result)