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BRENDA support

Ligand 2-hydroxyglutaric acid

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Basic Ligand Information

Molecular Formula
BRENDA Name
InChIKey
C5H8O5
2-hydroxyglutaric acid
HWXBTNAVRSUOJR-UHFFFAOYSA-N
Synonyms:
2-hydroxyglutarate, 2-hydroxypentandioic acid, 2-hydroxypentanedioate, alpha-hydroxyglutarate, DL-2-hydroxyglutarate, hydroxyglutarate

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
propanoyl-CoA + glyoxylate = 2-hydroxyglutarate + CoA
show the reaction diagram
-
S-hydroxyglutaryltrypanothione + H2O = hydroxyglutarate + trypanothione + 2 H+
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-hydroxyglutarate + oxidized acceptor = 2-oxoglutarate + reduced acceptor
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxoglutarate + NADH + H+ = 2-hydroxyglutarate + NAD+
show the reaction diagram
-
2-oxoglutarate + NADH + H+ = 2-hydroxypentanedioate + NAD+
show the reaction diagram
-
2-oxoglutarate + NADH + H+ = 2-hydroxyglutarate + NAD+
show the reaction diagram
-
2-oxoglutarate + NADPH + H+ = 2-hydroxyglutarate + NADP+
show the reaction diagram
-
2-oxoglutarate + NADH + H+ = 2-hydroxyglutarate + NAD+
show the reaction diagram
-
4-hydroxybutyrate + 2-oxoglutarate = succinic semialdehyde + 2-hydroxyglutarate
show the reaction diagram
-
S-hydroxyglutaryltrypanothione + H2O = hydroxyglutarate + trypanothione + 2 H+
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates at lower 2-oxoglutarate concentration
-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
product inhibition of the alpha-ketoglutarate reduction
-
D- and L-isomer, most potent competitive inhibitor
-
competitive inhibition
-

Enzyme Kinetic Parameters

References & Links

Links to other databases for 2-hydroxyglutaric acid

ChEBI
PubChem
ChEBI
PubChem