Ligand 2-hydroxyglutarate

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Basic Ligand Information

Molecular Structure
Picture of 2-hydroxyglutarate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H8O5
2-hydroxyglutarate
XXQAHBXLRFWCTG-UHFFFAOYSA-N
Synonyms:
2-hydroxyglutaric acid, 2-hydroxypentandioic acid, 2-hydroxypentanedioate, alpha-hydroxyglutarate, D-hydroxyglutarate, DL-2-hydroxyglutarate, hydroxyglutarate

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
propanoyl-CoA + glyoxylate = 2-hydroxyglutarate + CoA
show the reaction diagram
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S-hydroxyglutaryltrypanothione + H2O = hydroxyglutarate + trypanothione + 2 H+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-hydroxyglutarate + oxidized acceptor = 2-oxoglutarate + reduced acceptor
show the reaction diagram
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D-hydroxyglutarate + H2O + O2 = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxoglutarate + NADH + H+ = 2-hydroxyglutarate + NAD+
show the reaction diagram
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2-oxoglutarate + NADH + H+ = 2-hydroxypentanedioate + NAD+
show the reaction diagram
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2-oxopentanedioic acid + NADH + H+ = 2-hydroxypentandioic acid + NAD+
show the reaction diagram
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2-oxoglutarate + NADH + H+ = 2-hydroxyglutarate + NAD+
show the reaction diagram
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2-oxoglutarate + NADH + H+ = 2-hydroxyglutarate + NAD+
show the reaction diagram
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4-hydroxybutyrate + 2-oxoglutarate = succinic semialdehyde + 2-hydroxyglutarate
show the reaction diagram
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S-hydroxyglutaryltrypanothione + H2O = hydroxyglutarate + trypanothione + 2 H+
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates at lower 2-oxoglutarate concentration
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
product inhibition of the alpha-ketoglutarate reduction
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D- and L-isomer, most potent competitive inhibitor
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competitive inhibition
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Enzyme Kinetic Parameters

References & Links

Links to other databases for 2-hydroxyglutarate

ChEBI
PubChem
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PubChem