Ligand gamma-cyclodextrin

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Basic Ligand Information

Molecular Structure
Picture of gamma-cyclodextrin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C48H80O40
gamma-cyclodextrin
GDSRMADSINPKSL-HSEONFRVSA-N
Synonyms:
cG8, cyclooctaamylose, gamma-cyclodextrins, gamma-cyclomaltodextrin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
gamma-cyclodextrin + H2O = maltose + D-glucose
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
gamma-cyclodextrin + H2O = gamma-cyclodextrin + beta-D-glucose
show the reaction diagram
-
gamma-cyclodextrin + H2O = maltose + D-glucose
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (41 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
gamma-cyclodextrin + H2O = gamma-cyclodextrin + beta-D-glucose
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates GDE in liver
-
10 mM, activity is enhanced by 137%
-

Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
mixed-type competitive inhibition, the inhibitor can be accomodated in the glycogen storage site of T-state enzyme, subsite specificity
-
moderate inhibition by 10 mM, 30°C, 1 h
-
10 mM, 20% loss of activity
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (12 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.03
-
pH 3.5, 95°C

KM Value (28 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
6.8
-
pH 9, 50°C, Km-value shown as glucose equivalents
2.68
-
pH and temperature not specified in the publication
0.71
-
pH 3.5, 95°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
7.4
-
with respect to glycogen
0.00055
-
at pH 6.5 and 50°C

References & Links

Links to other databases for gamma-cyclodextrin

ChEBI
PubChem
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PubChem