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Ligand (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid
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Basic Ligand Information
C7H9NO5
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid
DVTPRYHENFBCII-IMJSIDKUSA-N
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate, (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate
BRENDA
KEGG
Show all BRENDA pathways known for (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid
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open all tablesRoles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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EC NUMBER 
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
In Vivo Product in Enzyme-catalyzed Reactions (3 results)
EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
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pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
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(S)-aspartate-4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O
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Substrate in Enzyme-catalyzed Reactions (4 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
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(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O
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(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O
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Product in Enzyme-catalyzed Reactions (7 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
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(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+
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(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+
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pyruvate + (R,S)-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
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pyruvate + DL-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
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pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
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(S)-aspartate-4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid + H2O
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Inhibitor in Enzyme-catalyzed Reactions (3 results)
EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
dihydrodipicolinate reductase enzymes from plants are much more prone to substrate inhibition than the bacterial enzymes, which appears to be a consequence of increased flexibility of the substrate-binding loop and higher affinity for the nucleotide substrate
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (8 results)
EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
KM Value (14 results)
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.043
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histidine-tagged enzyme, pH and temperature not specified in the publication
Ki Value (6 results)
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
References & Links
Literature References (12)
Links to other databases for (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid
ChEBI
PubChem
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Release 2023.1 (January 2023)
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