Ligand histone H3 N6,N6-dimethyl-L-lysine9

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of histone H3 N6,N6-dimethyl-L-lysine9 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H50N10O9R2
histone H3 N6,N6-dimethyl-L-lysine9
Synonyms:
a [histone H3]-N6,N6-dimethyl-L-lysine9, dimethyl-histone 3 lysine 9, dimethylated histone 3 lysine 9, [histone H3]-N6,N6-dimethyl-L-lysine9, [histone H3]-N6,N6-dimethyl-L-lysine 9

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
-
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
-
[histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 = [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
show the reaction diagram
-
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 = histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 = histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 = [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine9
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
-
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
-
[histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 = [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
show the reaction diagram
-
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 = histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 = histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
-
-
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 = [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
-
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (12 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (12 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for histone H3 N6,N6-dimethyl-L-lysine9

ChEBI
PubChem
-
-