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Ligand (2E,6Z)-farnesyl diphosphate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.3.70

(2E,6Z)-farnesyl diphosphate = patchoulol + diphosphate

746782

-

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.91

(2E,6Z)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + decaprenyl diphosphate

704266

-

4.2.3.13

(2E,6Z)-farnesyl diphosphate = (+)-delta-cadinene + diphosphate

702321

-

4.2.3.70

(2E,6Z)-farnesyl diphosphate = patchoulol + diphosphate

746782

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (5 results)

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Show Turnover Number (5 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.5.1.91

11.5

-

pH 7.9, 37°C

704266

4.2.3.13

0.01

-

wild-type protein

702321

4.2.3.13

0.012

-

D308A mutant protein

702321

4.2.3.13

0.014

-

D452A mutant protein

702321

4.2.3.13

0.043

-

D451A mutant protein

702321

4.2.3.13

4 entries

K_M Value (5 results)

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Show KM Value (5 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.5.1.91

0.29

-

pH 7.9, 37°C

704266

4.2.3.13

0.0024

-

D451A mutant protein

702321

4.2.3.13

0.0031

-

D452A mutant protein

702321

4.2.3.13

0.0032

-

wild-type protein

702321

4.2.3.13

0.043

-

D308A mutant protein

702321

4.2.3.13

4 entries

References & Links

Literature References (3)

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Show Reference (3 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

702321

19489610

Crystal structure of (+)-delta-cadinene synthase from Gossypium arboreum and evolutionary divergence of metal binding motifs for catalysis

2009

ennadios, H.A.; Gonzalez, V.; Di Costanzo, L.; Li, A.; Yu, F.; Miller, D.J.; Allemann, R.K.; Christianson, D.W.

Biochemistry

48

6175-6183

704266

15516568

Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis

2004

Kaur, D.; Brennan, P.J.; Crick, D.C.

J. Bacteriol.

186

7564-7570

746782

26100386

Characterisation of a recombinant patchoulol synthase variant for biocatalytic production of terpenes

2015

Frister, T.; Hartwig, S.; Alemdar, S.; Schnatz, K.; Thoens, L.; Scheper, T.; Beutel, S.

Appl. Biochem. Biotechnol.

176

2185-2201

Links to other databases for (2E,6Z)-farnesyl diphosphate

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Show Links (1 entry)

ChEBI

PubChem