Ligand D-aspartic acid

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Basic Ligand Information

Molecular Structure
Picture of D-aspartic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H7NO4
D-aspartic acid
CKLJMWTZIZZHCS-UWTATZPHSA-N
Synonyms:
(2R)-2-amino-3-carboxypropanoate, D-Asp, D-Aspartate


Show all pahtways known for Show all BRENDA pathways known for D-aspartic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-aspartic acid + H2O + O2 = oxaloacetate + NH3 + H2O2
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D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2
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In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-asparagine + H2O = D-aspartate + NH3
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L-aspartate = D-aspartate
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Substrate in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-aspartic acid + H2O + O2 = oxaloacetate + NH3 + H2O2
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D-aspartate + H2O + O2 = ?
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D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2
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D-Asp + H2O + oxidized 2,6-dichlorophenolindophenol = 2-oxobutanedioate + NH3 + reduced 2,6-dichlorophenolindophenol
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D-aspartate + oxidized 2,6-dichloroindophenol + H2O = oxaloacetate + NH3 + reduced 2,6-dichloroindophenol
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D-aspartate + 2-oxoadipate = oxaloacetate + 2-aminoadipate
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D-aspartate = L-aspartate
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ATP + D-aspartate + tRNAAsp = AMP + diphosphate + D-aspartyl-tRNAAsp
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ATP + D-Asp = ADP + phosphate + D-Asp-D-Asp
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Product in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-aspartate dimethyl ester + H2O = D-aspartate + methanol
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Gly-D-Asp + H2O = Gly + D-Asp
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L-Arg-D-Asp + H2O = L-Arg + D-Asp
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D-asparagine + H2O = D-aspartate + NH3
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N-carbamoyl-D-Asp + H2O = D-Asp + NH3 + CO2
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N-acetyl-D-aspartate + H2O = acetate + D-aspartate
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L-aspartate = D-aspartate
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L-aspartate = D-aspartate
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Activator in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2 mM, 1.27fold activation
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substrate activation at D-aspartate concentrations above 0.2 mM
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5700% activation
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increases activity
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Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
90% activity in the presence of 10 mM D-aspartate
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inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak
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weak inhibition
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competitive
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-
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weak
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weak
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3D Structure of Enzyme-Ligand-Complex (PDB) (5 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (48 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (83 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
94
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in 50 mM Tris-HCl buffer, pH 8.0, at 30°C

References & Links

Links to other databases for D-aspartic acid

ChEBI
PubChem
ChEBI
PubChem