print visible entries

print all entries

Ligand 5-methylthio-2-oxopentanoate

Basic Ligand Information

Molecular Structure

close all tables

open all tables

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

top print hide

Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.3.17

5-methylthio-2-oxopentanoate + acetyl-CoA + H2O = 2-(3'-methylthiopropyl)malate + CoA

741321, 741215, 741119

-

2.3.3.17

5-methylthio-2-oxopentanoate + acetyl-CoA + H2O = ?

741153

-

2.3.3.17

5-methylthio-2-oxopentanoate + acetyl-CoA = ?

741197

-

2.3.3.17

3 entries

2.6.1.88

5-methylthio-2-oxopentanoate + ? = L-methionine + a 2-oxo acid

676421

-

Product in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.42

L-homomethionine + 2-oxoglutarate = 5-methylthio-2-oxopentanoate + L-glutamate

0

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

top print hide

Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.3.3.17

1.3

-

at pH 8.0 and 32°C

741197

K_M Value (2 results)

top print hide

Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.3.17

0.476

-

at pH 8.0 and 32°C

741197

2.3.3.17

0.64

-

at pH 8.5 and 32°C

741215

2.3.3.17

2 entries

References & Links

Literature References (6)

top print hide

Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

676421

17056707

Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis

2006

Schuster, J.; Knill, T.; Reichelt, M.; Gershenzon, J.; Binder, S.

Plant Cell

18

2664-2679

741119

-

Methylthioalkylmalate synthases: Genetics, ecology and evolution

2009

Benderoth, M.; Pfalz, M.; Kroymann, J.

Phytochem. Rev.

8

255-268

741153

21205930

From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis

2011

de Kraker, J.W.; Gershenzon, J.

Plant Cell

23

38-53

741197

17369439

MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis

2007

Textor, S.; de Kraker, J.W.; Hause, B.; Gershenzon, J.; Tokuhisa, J.G.

Plant Physiol.

144

60-71

741215

14740211

Biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana: recombinant expression and characterization of methylthioalkylmalate synthase, the condensing enzyme of the chain-elongation cycle

2004

Textor, S.; Bartram, S.; Kroymann, J.; Falk, K.L.; Hick, A.; Pickett, J.A.; Gershenzon, J.

Planta

218

1026-1035

741321

16754868

Positive selection driving diversification in plant secondary metabolism

2006

Benderoth, M.; Textor, S.; Windsor, A.; Mitchell-Olds, T.; Gershenzon, J.; Kroymann, J.

Proc. Natl. Acad. Sci. USA

103

9118-9123

Links to other databases for 5-methylthio-2-oxopentanoate

top print hide

Show Links (1 entry)

ChEBI

PubChem