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Ligand 6-aminouridine 5'-monophosphate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Inhibitor in Enzyme-catalyzed Reactions (24 results)

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Show Inhibitors (24 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

4.1.1.23

competitive inhibition

681286

3DBP, 3D-view

4.1.1.23

competitive inhibition

681286

3N3M, 3D-view

4.1.1.23

competitive inhibition

681286

3THQ, 3D-view

4.1.1.23

competitive inhibition

681286

3WJX, 3D-view

4.1.1.23

competitive inhibition

681286

3WJY, 3D-view

4.1.1.23

competitive inhibition

681286

3WJZ, 3D-view

4.1.1.23

-

693558

3DBP, 3D-view

4.1.1.23

-

693558

3N3M, 3D-view

4.1.1.23

-

693558

3THQ, 3D-view

4.1.1.23

-

693558

3WJX, 3D-view

4.1.1.23

-

693558

3WJY, 3D-view

4.1.1.23

-

693558

3WJZ, 3D-view

4.1.1.23

-

694055, 694477

3DBP, 3D-view

4.1.1.23

-

694055, 694477

3N3M, 3D-view

4.1.1.23

-

694055, 694477

3THQ, 3D-view

4.1.1.23

-

694055, 694477

3WJX, 3D-view

4.1.1.23

-

694055, 694477

3WJY, 3D-view

4.1.1.23

-

694055, 694477

3WJZ, 3D-view

4.1.1.23

-

693558

3DBP, 3D-view

4.1.1.23

-

693558

3N3M, 3D-view

4.1.1.23

-

693558

3THQ, 3D-view

4.1.1.23

-

693558

3WJX, 3D-view

4.1.1.23

-

693558

3WJY, 3D-view

4.1.1.23

-

693558

3WJZ, 3D-view

4.1.1.23

24 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (24 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (24 entries)

EC NUMBER

ENZYME 3D STRUCTURE

4.1.1.23

3DBP, 3D-view

4.1.1.23

3N3M, 3D-view

4.1.1.23

3THQ, 3D-view

4.1.1.23

3WJX, 3D-view

4.1.1.23

3WJY, 3D-view

4.1.1.23

3WJZ, 3D-view

4.1.1.23

3DBP, 3D-view

4.1.1.23

3N3M, 3D-view

4.1.1.23

3THQ, 3D-view

4.1.1.23

3WJX, 3D-view

4.1.1.23

3WJY, 3D-view

4.1.1.23

3WJZ, 3D-view

4.1.1.23

3DBP, 3D-view

4.1.1.23

3N3M, 3D-view

4.1.1.23

3THQ, 3D-view

4.1.1.23

3WJX, 3D-view

4.1.1.23

3WJY, 3D-view

4.1.1.23

3WJZ, 3D-view

4.1.1.23

3DBP, 3D-view

4.1.1.23

3N3M, 3D-view

4.1.1.23

3THQ, 3D-view

4.1.1.23

3WJX, 3D-view

4.1.1.23

3WJY, 3D-view

4.1.1.23

3WJZ, 3D-view

4.1.1.23

24 entries

Enzyme Kinetic Parameters

K_i Value (4 results)

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Show KI Value (4 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

4.1.1.23

0.00084

-

pH 7.5, 55°C

681286

4.1.1.23

0.00084

-

-

694477

4.1.1.23

0.00084

-

-

693558

4.1.1.23

0.0021

-

-

693558

4.1.1.23

4 entries

References & Links

Literature References (4)

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Show Reference (4 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

681286

16884305

Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics

2006

Poduch, E.; Bello, A.M.; Tang, S.; Fujihashi, M.; Pai, E.F.; Kotra, L.P.

J. Med. Chem.

49

4937-4945

693558

18189347

Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase

2008

Bello, A.M.; Poduch, E.; Liu, Y.; Wei, L.; Crandall, I.; Wang, X.; Dyanand, C.; Kain, K.C.; Pai, E.F.; Kotra, L.P.

J. Med. Chem.

51

439-448

694055

18336344

Inhibition of orotidine 5-monophosphate decarboxylase and its therapeutic potential

2008

Meza-Avina, M.E.; Wei, L.; Buhendwa, M.G.; Poduch, E.; Bello, A.M.; Pai, E.F.; Kotra, L.P.

Mini Rev. Med. Chem.

8

239-247

694477

18776265

Inhibition of orotidine-5-monophosphate decarboxylase--discoveries and lessons

2008

Kotra, L.P.; Pai, E.F.

Nucleic Acids Symp. Ser.

52

85-86

Links to other databases for 6-aminouridine 5'-monophosphate

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Show Links (1 entry)